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Protein

Iroquois-class homeodomain protein IRX-5

Gene

Irx5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina. Involved in craniofacial and gonadal development (By similarity). Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi112 – 174Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processSensory transduction, Transcription, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-5
Alternative name(s):
Homeodomain protein IRXB2
Iroquois homeobox protein 5
Gene namesi
Name:Irx5
Synonyms:Irxb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1859086 Irx5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Disruption causes increased KCND2 potassium-channel expression in endocardial myocardium leading to abolition of the cardiac repolarization gradient, a selective increase of the major cardiac repolarization current, I(to,f), and increased susceptibility to arrhythmias.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491611 – 484Iroquois-class homeodomain protein IRX-5Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273PhosphoserineBy similarity1
Modified residuei465PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JKQ4
PRIDEiQ9JKQ4

PTM databases

iPTMnetiQ9JKQ4
PhosphoSitePlusiQ9JKQ4

Expressioni

Tissue specificityi

Not expressed in the developing metanephric kidney or adult kidney.

Developmental stagei

In E9.5 embryos, expressed in the rhombencephalon, metencephalon, and in the cephalic mesoderm surround the optic vesicle. By E12.5, expression continues in the mesenchyme and also begins in subsets of cells in the neuroretina, becoming expressed in the retinal inner neuroblast layers by E16.5. Expressed in developing bipolar cells during retinal development starting at postnatal day 5, and expressed in a subset of cone bipolar cells in the mature retina. Also expressed along the spinal cord, in the ventricular layer, in motor neurons and in the proximal limb buds during embryonic development. Expressed in the developing heart in the endocardium that lines the heart chambers.3 Publications

Gene expression databases

BgeeiENSMUSG00000031737 Expressed in 228 organ(s), highest expression level in maxillary prominence
CleanExiMM_IRX5
ExpressionAtlasiQ9JKQ4 baseline and differential
GenevisibleiQ9JKQ4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034184

Structurei

3D structure databases

ProteinModelPortaliQ9JKQ4
SMRiQ9JKQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi72 – 78Poly-Ala7
Compositional biasi185 – 191Poly-Glu7
Compositional biasi319 – 327Poly-Pro9
Compositional biasi351 – 354Poly-Gly4

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOGENOMiHOG000234546
HOVERGENiHBG006180
InParanoidiQ9JKQ4
OrthoDBiEOG091G15AO
PhylomeDBiQ9JKQ4
TreeFamiTF319371

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JKQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYPQGYLYQ PSASLALYSC PAYSTSVISG PRTDELGRSS SGSAFSPYAG
60 70 80 90 100
STAFTAPSPG YNSHLQYGAD PAAAAAAAFS YVGSPYDHTP GMAGSLGYHP
110 120 130 140 150
YAAPLGSYPY GDPAYRKNAT RDATATLKAW LNEHRKNPYP TKGEKIMLAI
160 170 180 190 200
ITKMTLTQVS TWFANARRRL KKENKMTWTP RNRSEDEEEE ENIDLEKNDE
210 220 230 240 250
DEPQKPEDKG DLEGPESGGA EQKATAGCER LQGPLSPAGK ETEGSLSDSD
260 270 280 290 300
FKESSSEGRH DELPRPPRAG ESSPAGPATA RLAEDAGPHY PASVPAPGPH
310 320 330 340 350
PSAGELPPGS GGSSVIHSPP PPPPPPPAVL AKPKLWSLAE IATSSDKVKD
360 370 380 390 400
GGGGSEGSPC PPCPGPMGGQ TLGGSRASPA PAPARSPSAQ CPFPGGTVLS
410 420 430 440 450
RPLYYTAPFY PGYTNYGSFG HLHGHPGPGP SPTAGPGSHF NGLNQTVLNR
460 470 480
ADVLAKDPKM LRSQSQLDLC KDSPYELKKG MSDI
Length:484
Mass (Da):50,755
Last modified:October 1, 2000 - v1
Checksum:i4C9AB3ED9992EDC9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GR17A0A1B0GR17_MOUSE
Iroquois-class homeodomain protein ...
Irx5
516Annotation score:

Sequence cautioni

The sequence AAF63955 differs from that shown. Reason: Frameshift at position 430.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230074 mRNA Translation: AAF42871.1
AK004747 mRNA Translation: BAB23528.1
BC051959 mRNA Translation: AAH51959.2
BC056994 mRNA Translation: AAH56994.1
AF165985 mRNA Translation: AAF63955.1 Frameshift.
CCDSiCCDS22522.1
RefSeqiNP_061296.1, NM_018826.2
UniGeneiMm.101153

Genome annotation databases

EnsembliENSMUST00000034184; ENSMUSP00000034184; ENSMUSG00000031737
GeneIDi54352
KEGGimmu:54352
UCSCiuc009mub.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230074 mRNA Translation: AAF42871.1
AK004747 mRNA Translation: BAB23528.1
BC051959 mRNA Translation: AAH51959.2
BC056994 mRNA Translation: AAH56994.1
AF165985 mRNA Translation: AAF63955.1 Frameshift.
CCDSiCCDS22522.1
RefSeqiNP_061296.1, NM_018826.2
UniGeneiMm.101153

3D structure databases

ProteinModelPortaliQ9JKQ4
SMRiQ9JKQ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034184

PTM databases

iPTMnetiQ9JKQ4
PhosphoSitePlusiQ9JKQ4

Proteomic databases

PaxDbiQ9JKQ4
PRIDEiQ9JKQ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034184; ENSMUSP00000034184; ENSMUSG00000031737
GeneIDi54352
KEGGimmu:54352
UCSCiuc009mub.1 mouse

Organism-specific databases

CTDi10265
MGIiMGI:1859086 Irx5

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOGENOMiHOG000234546
HOVERGENiHBG006180
InParanoidiQ9JKQ4
OrthoDBiEOG091G15AO
PhylomeDBiQ9JKQ4
TreeFamiTF319371

Miscellaneous databases

PROiPR:Q9JKQ4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031737 Expressed in 228 organ(s), highest expression level in maxillary prominence
CleanExiMM_IRX5
ExpressionAtlasiQ9JKQ4 baseline and differential
GenevisibleiQ9JKQ4 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIRX5_MOUSE
AccessioniPrimary (citable) accession number: Q9JKQ4
Secondary accession number(s): Q80WV4, Q9JLL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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