UniProtKB - Q9JKN6 (NOVA1_MOUSE)

BLAST

>sp|Q9JKN6|NOVA1_MOUSE RNA-binding protein Nova-1 OS=Mus musculus OX=10090 GN=Nova1 PE=1 SV=2
MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYA
AGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLIQGTIEALNAVHGFIAEKI
REMPQNVAKTEPVSILQPQTTVNPDRIKQTLPSSPTTTKSSPSDPMTTSRANQVKIIVPN
STAGLIIGKGGATVKAIMEQSGAWVQLSQKPDGINLQERVVTVSGEPEQNRKAVELIIQK
IQEDPQSGSCLNISYANVTGPVANSNPTGSPYANTAEVLPTAAAAAGLLGHANLAGVAAF
PAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAAN
LLATYASEASASGSTAGGTAGTFALGSLAAATAATNGYFGAASPLAASAILGTEKSTDGS
KDVVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFVPGTRNRKVTITGTPAA
TQAAQYLITQRITYEQGVRAANPQKVG

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History
Entry version 130 (12 Sep 2018)
Sequence version 2 (09 Jan 2007)
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Protein

RNA-binding protein Nova-1

Gene

Nova1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion. It binds specifically to the sequence UCAUY. Most likely acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer.3 Publications

GO - Molecular functionⁱ

mRNA binding
Source: MGI
Inferred from direct assayⁱ
- 10719891

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA splicing, via spliceosome
Source: MGI
Inferred from direct assayⁱ
- 10719891
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from genetic interactionⁱ
- 27635635
regulation of mRNA processing Source: MGI
regulation of RNA metabolic process
Source: MGI
Inferred from genetic interactionⁱ
- 23359859

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding

Molecular function

RNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RNA-binding protein Nova-1 Alternative name(s): Neuro-oncological ventral antigen 1 Ventral neuron-specific protein 1
Gene namesⁱ	Name:Nova1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:104297 Nova1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Defects in Nova1 leads to neuronal death in spinal and brainstem neurons.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050117	1 – 507	RNA-binding protein Nova-1Add BLAST		507

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	154	Phosphoserine1 Publication		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9JKN6
PaxDbⁱ	Q9JKN6
PeptideAtlas More...PeptideAtlasⁱ	Q9JKN6
PRIDEⁱ	Q9JKN6

PTM databases

iPTMnetⁱ	Q9JKN6
PhosphoSitePlusⁱ	Q9JKN6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000021047 Expressed in 208 organ(s), highest expression level in midbrain
CleanExⁱ	MM_NOVA1
ExpressionAtlasⁱ	Q9JKN6 baseline and differential
Genevisibleⁱ	Q9JKN6 MM

Interactionⁱ

Subunit structureⁱ

Interacts with PTBP2; the interaction is direct.1 Publication

Protein-protein interaction databases

BioGridⁱ	576757, 2 interactors
IntActⁱ	Q9JKN6, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q9JKN6
STRINGⁱ	10090.ENSMUSP00000021438

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9JKN6
SMRⁱ	Q9JKN6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	49 – 116	KH 1PROSITE-ProRule annotationAdd BLAST	68
Domainⁱ	171 – 237	KH 2PROSITE-ProRule annotationAdd BLAST	67
Domainⁱ	421 – 488	KH 3PROSITE-ProRule annotationAdd BLAST	68

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	27 – 43	Bipartite nuclear localization signalSequence analysisAdd BLAST		17

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	273 – 409	Ala-richAdd BLAST		137

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG2191 Eukaryota ENOG410XRZD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119144
HOGENOMⁱ	HOG000007833
HOVERGENⁱ	HBG082048
InParanoidⁱ	Q9JKN6
KEGG Orthology (KO) More...KOⁱ	K14944
OMAⁱ	VVDFIMD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G185U
PhylomeDBⁱ	Q9JKN6
TreeFamⁱ	TF316981

Family and domain databases

Gene3Dⁱ	3.30.1370.10, 3 hits
InterProⁱ	View protein in InterPro IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR033086 NOVA1
PANTHERⁱ	PTHR10288:SF223 PTHR10288:SF223, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00013 KH_1, 3 hits
SMARTⁱ	View protein in SMART SM00322 KH, 3 hits
SUPFAMⁱ	SSF54791 SSF54791, 3 hits
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9JKN6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMAAAPIQQN GTHTGVPIDL DPPDSRKRPL EAPPEAGSTK RTNTGEDGQY 
        60         70         80         90        100
FLKVLIPSYA AGSIIGKGGQ TIVQLQKETG ATIKLSKSKD FYPGTTERVC 
       110        120        130        140        150
LIQGTIEALN AVHGFIAEKI REMPQNVAKT EPVSILQPQT TVNPDRIKQT 
       160        170        180        190        200
LPSSPTTTKS SPSDPMTTSR ANQVKIIVPN STAGLIIGKG GATVKAIMEQ 
       210        220        230        240        250
SGAWVQLSQK PDGINLQERV VTVSGEPEQN RKAVELIIQK IQEDPQSGSC 
       260        270        280        290        300
LNISYANVTG PVANSNPTGS PYANTAEVLP TAAAAAGLLG HANLAGVAAF 
       310        320        330        340        350
PAVLSGFTGN DLVAITSALN TLASYGYNLN TLGLGLSQAA ATGALAAAAA 
       360        370        380        390        400
SANPAAAAAN LLATYASEAS ASGSTAGGTA GTFALGSLAA ATAATNGYFG 
       410        420        430        440        450
AASPLAASAI LGTEKSTDGS KDVVEIAVPE NLVGAILGKG GKTLVEYQEL 
       460        470        480        490        500
TGARIQISKK GEFVPGTRNR KVTITGTPAA TQAAQYLITQ RITYEQGVRA 

ANPQKVG

Length:507

Mass (Da):51,756

Last modified:January 9, 2007 - v2

Checksum:ⁱEB68F2D777BF8135

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A1W2P6P4	A0A1W2P6P4_MOUSE	RNA-binding protein Nova-1 RNA-binding protein Nova-1	Nova1	112	Annotation score:
A0A1W2P6S8	A0A1W2P6S8_MOUSE	RNA-binding protein Nova-1 RNA-binding protein Nova-1	Nova1	66	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC108802 Genomic DNA No translation available. AC156636 Genomic DNA No translation available. AF232828 mRNA Translation: AAF35907.1 AK047565 mRNA Translation: BAC33088.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS49058.1
NCBI Reference Sequences More...RefSeqⁱ	NP_067336.1, NM_021361.1
UniGeneⁱ	Mm.247195

Genome annotation databases

Ensemblⁱ	ENSMUST00000021438; ENSMUSP00000021438; ENSMUSG00000021047
GeneIDⁱ	664883
KEGGⁱ	mmu:664883
UCSC genome browser More...UCSCⁱ	uc007nmd.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9JKN6	RNA-binding protein Nova-1	)	HUMAN		510	UniRef90_P51513
RNA-binding protein Nova-1 isoform 1		CALJA		507
NOVA alternative splicing regulator 1		PANTR		507
NOVA alternative splicing regulator 1		MACMU		507
RNA-binding protein Nova-1		MACFA		507
+86

Protein	Similar proteins		Species	Score	Length	Source
Q9JKN6	RNA-binding protein Nova-1	)	HUMAN		510	UniRef50_P51513
Uncharacterized protein		CAVPO		507
RNA-binding protein Nova-1 isoform 1		CALJA		507
NOVA alternative splicing regulator 1		PANTR		507
NOVA alternative splicing regulator 1		MACMU		507
+166

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC108802 Genomic DNA No translation available. AC156636 Genomic DNA No translation available. AF232828 mRNA Translation: AAF35907.1 AK047565 mRNA Translation: BAC33088.1
CCDSⁱ	CCDS49058.1
RefSeqⁱ	NP_067336.1, NM_021361.1
UniGeneⁱ	Mm.247195

3D structure databases

ProteinModelPortalⁱ	Q9JKN6
SMRⁱ	Q9JKN6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	576757, 2 interactors
IntActⁱ	Q9JKN6, 1 interactor
MINTⁱ	Q9JKN6
STRINGⁱ	10090.ENSMUSP00000021438

PTM databases

iPTMnetⁱ	Q9JKN6
PhosphoSitePlusⁱ	Q9JKN6

Proteomic databases

MaxQBⁱ	Q9JKN6
PaxDbⁱ	Q9JKN6
PeptideAtlasⁱ	Q9JKN6
PRIDEⁱ	Q9JKN6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000021438; ENSMUSP00000021438; ENSMUSG00000021047
GeneIDⁱ	664883
KEGGⁱ	mmu:664883
UCSCⁱ	uc007nmd.2 mouse

Organism-specific databases

CTDⁱ	4857
MGIⁱ	MGI:104297 Nova1

Phylogenomic databases

eggNOGⁱ	KOG2191 Eukaryota ENOG410XRZD LUCA
GeneTreeⁱ	ENSGT00760000119144
HOGENOMⁱ	HOG000007833
HOVERGENⁱ	HBG082048
InParanoidⁱ	Q9JKN6
KOⁱ	K14944
OMAⁱ	VVDFIMD
OrthoDBⁱ	EOG091G185U
PhylomeDBⁱ	Q9JKN6
TreeFamⁱ	TF316981

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9JKN6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000021047 Expressed in 208 organ(s), highest expression level in midbrain
CleanExⁱ	MM_NOVA1
ExpressionAtlasⁱ	Q9JKN6 baseline and differential
Genevisibleⁱ	Q9JKN6 MM

Family and domain databases

Gene3Dⁱ	3.30.1370.10, 3 hits
InterProⁱ	View protein in InterPro IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR033086 NOVA1
PANTHERⁱ	PTHR10288:SF223 PTHR10288:SF223, 1 hit
Pfamⁱ	View protein in Pfam PF00013 KH_1, 3 hits
SMARTⁱ	View protein in SMART SM00322 KH, 3 hits
SUPFAMⁱ	SSF54791 SSF54791, 3 hits
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NOVA1_MOUSE
Accessionⁱ	Q9JKN6Primary (citable) accession number: Q9JKN6 Secondary accession number(s): Q8C8B9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 4, 2003
	Last sequence update:	January 9, 2007
	Last modified:	September 12, 2018
	This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9JKN6 (NOVA1_MOUSE)

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RNA-binding protein Nova-1

Nova1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ