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Protein

Oligodendrocyte transcription factor 1

Gene

Olig1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: MGI
  • protein dimerization activity Source: InterPro

GO - Biological processi

  • neuron fate commitment Source: MGI
  • oligodendrocyte differentiation Source: InterPro
  • regulation of transcription, DNA-templated Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 1
Short name:
Oligo1
Alternative name(s):
Oligodendrocyte-specific bHLH transcription factor 1
Gene namesi
Name:Olig1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1355334 Olig1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274121 – 260Oligodendrocyte transcription factor 1Add BLAST260

Proteomic databases

PaxDbiQ9JKN5
PRIDEiQ9JKN5

PTM databases

iPTMnetiQ9JKN5
PhosphoSitePlusiQ9JKN5

Expressioni

Tissue specificityi

Expressed specifically in brain.1 Publication

Developmental stagei

Expressed in the ventral spinal cord as early as 9.5 dpc. Expression declines to undetectable levels by 10.5 dpc and reappears in a narrow zone within the ventral neuroepithelium of the spinal cord. In the 14.5 dpc spinal cord, expressed in the oligodendrocyte progenitors of the ventral ventricular zone, but not dorsal root ganglia Schwann cells. Also expressed scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. By 15.5 dpc, dispersed throughout the gray matter, with little or no residual expression in the ventricular zone. In the postnatal brain, present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Expressed in the olfactory epithelium from 11.5dpc onward.1 Publication

Inductioni

By SHH.1 Publication

Gene expression databases

BgeeiENSMUSG00000046160 Expressed in 133 organ(s), highest expression level in ventral horn of spinal cord
CleanExiMM_OLIG1
ExpressionAtlasiQ9JKN5 baseline and differential
GenevisibleiQ9JKN5 MM

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206153, 5 interactors
IntActiQ9JKN5, 5 interactors
MINTiQ9JKN5
STRINGi10090.ENSMUSP00000061408

Structurei

3D structure databases

ProteinModelPortaliQ9JKN5
SMRiQ9JKN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 153bHLHPROSITE-ProRule annotationAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 52Poly-Ser9
Compositional biasi90 – 94Poly-Gln5

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG4111U26 LUCA
GeneTreeiENSGT00530000063239
HOGENOMiHOG000015810
HOVERGENiHBG053369
InParanoidiQ9JKN5
KOiK09085
OMAiCQSSPGR
OrthoDBiEOG091G0IHI
PhylomeDBiQ9JKN5
TreeFamiTF322733

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032657 Olig1
PANTHERiPTHR19290:SF7 PTHR19290:SF7, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JKN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYYAISQARV NAAPATMLRP QRPGDVQLGA SLYELVGYRQ PPISSSSSSS
60 70 80 90 100
SSTASLLPKP AREKAEAPLA EPRGPAPESG GARADAKEEQ QQQQLRRKIN
110 120 130 140 150
SRERKRMQDL NLAMDALREV ILPYSAAHCQ GAPGRKLSKI ATLLLARNYI
160 170 180 190 200
LLLGSSLQEL RRALGDGAGP AAPRLLLAGL PLLAAAPGSV LLAPGAVGPP
210 220 230 240 250
ETLRPTKYLS LALDEPPCGQ FSLPAGGAGS PGLCSCAVCK FPHLVPAGLG
260
LAAVQAQFSK
Length:260
Mass (Da):27,141
Last modified:August 30, 2002 - v2
Checksum:i5EA8A74D9DF0D310
GO

Sequence cautioni

The sequence BAB18906 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038696 mRNA Translation: BAB18906.1 Different initiation.
BC046316 mRNA Translation: AAH46316.1
AF232928 Genomic DNA Translation: AAF61721.1
CCDSiCCDS28324.1
RefSeqiNP_058664.2, NM_016968.4
UniGeneiMm.39300

Genome annotation databases

EnsembliENSMUST00000056882; ENSMUSP00000061408; ENSMUSG00000046160
GeneIDi50914
KEGGimmu:50914
UCSCiuc007zxf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038696 mRNA Translation: BAB18906.1 Different initiation.
BC046316 mRNA Translation: AAH46316.1
AF232928 Genomic DNA Translation: AAF61721.1
CCDSiCCDS28324.1
RefSeqiNP_058664.2, NM_016968.4
UniGeneiMm.39300

3D structure databases

ProteinModelPortaliQ9JKN5
SMRiQ9JKN5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206153, 5 interactors
IntActiQ9JKN5, 5 interactors
MINTiQ9JKN5
STRINGi10090.ENSMUSP00000061408

PTM databases

iPTMnetiQ9JKN5
PhosphoSitePlusiQ9JKN5

Proteomic databases

PaxDbiQ9JKN5
PRIDEiQ9JKN5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056882; ENSMUSP00000061408; ENSMUSG00000046160
GeneIDi50914
KEGGimmu:50914
UCSCiuc007zxf.1 mouse

Organism-specific databases

CTDi116448
MGIiMGI:1355334 Olig1

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG4111U26 LUCA
GeneTreeiENSGT00530000063239
HOGENOMiHOG000015810
HOVERGENiHBG053369
InParanoidiQ9JKN5
KOiK09085
OMAiCQSSPGR
OrthoDBiEOG091G0IHI
PhylomeDBiQ9JKN5
TreeFamiTF322733

Miscellaneous databases

PROiPR:Q9JKN5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046160 Expressed in 133 organ(s), highest expression level in ventral horn of spinal cord
CleanExiMM_OLIG1
ExpressionAtlasiQ9JKN5 baseline and differential
GenevisibleiQ9JKN5 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032657 Olig1
PANTHERiPTHR19290:SF7 PTHR19290:SF7, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOLIG1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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