Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-37

Gene

Rab37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 43GTPBy similarity8
Nucleotide bindingi85 – 89GTPBy similarity5
Nucleotide bindingi143 – 146GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • Rab protein signal transduction Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-37
Gene namesi
Name:Rab37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1929945 Rab37

Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001212502 – 220Ras-related protein Rab-37Add BLAST219
PropeptideiPRO_0000370829221 – 223Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Lipidationi219S-geranylgeranyl cysteineBy similarity1
Modified residuei220Cysteine methyl esterSequence analysis1
Lipidationi220S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ9JKM7
MaxQBiQ9JKM7
PaxDbiQ9JKM7
PRIDEiQ9JKM7

PTM databases

PhosphoSitePlusiQ9JKM7

Expressioni

Tissue specificityi

Specifically expressed in the bone marrow mast cells.

Gene expression databases

CleanExiMM_RAB37

Interactioni

Subunit structurei

Interacts with RIMS1.1 Publication

Protein-protein interaction databases

BioGridi208399, 2 interactors
IntActiQ9JKM7, 5 interactors
STRINGi10090.ENSMUSP00000021076

Structurei

3D structure databases

ProteinModelPortaliQ9JKM7
SMRiQ9JKM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi59 – 67Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0083 Eukaryota
ENOG410Z9H6 LUCA
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9JKM7
KOiK07914
PhylomeDBiQ9JKM7

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JKM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGTPGAATA GDGEAPERSP PFSPNYDLTG KVMLLGDSGV GKTCFLIQFK
60 70 80 90 100
DGAFLSGTFI ATVGIDSRNK VVTVDGARVK LQIWDTAGQE RFRSVTHAYY
110 120 130 140 150
RDAQALLLLY DITNQSSFDN IRAWLTEIHE YAQRDVVIML LGNKADVSSE
160 170 180 190 200
RVIRSEDGET LAREYGVPFM ETSAKTGMNV ELAFLAIAKE LKYRAGRQPD
210 220
EPSFQIRDYV ESQKKRSSCC SFV
Length:223
Mass (Da):24,656
Last modified:April 26, 2004 - v2
Checksum:i8C500ED4CE854C24
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q544E8Q544E8_MOUSE
RAB37, member of RAS oncogene famil...
Rab37 mCG_6631
223Annotation score:
Q8BQX0Q8BQX0_MOUSE
RAB37, member of RAS oncogene famil...
Rab37 mCG_6631
216Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67S → F in AAF67162 (PubMed:10722846).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233582 mRNA Translation: AAF67162.1
AK050483 mRNA Translation: BAC34282.1
CCDSiCCDS25620.1
RefSeqiNP_067386.3, NM_021411.4
UniGeneiMm.143789

Genome annotation databases

GeneIDi58222
KEGGimmu:58222

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233582 mRNA Translation: AAF67162.1
AK050483 mRNA Translation: BAC34282.1
CCDSiCCDS25620.1
RefSeqiNP_067386.3, NM_021411.4
UniGeneiMm.143789

3D structure databases

ProteinModelPortaliQ9JKM7
SMRiQ9JKM7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208399, 2 interactors
IntActiQ9JKM7, 5 interactors
STRINGi10090.ENSMUSP00000021076

PTM databases

PhosphoSitePlusiQ9JKM7

Proteomic databases

EPDiQ9JKM7
MaxQBiQ9JKM7
PaxDbiQ9JKM7
PRIDEiQ9JKM7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi58222
KEGGimmu:58222

Organism-specific databases

CTDi326624
MGIiMGI:1929945 Rab37

Phylogenomic databases

eggNOGiKOG0083 Eukaryota
ENOG410Z9H6 LUCA
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9JKM7
KOiK07914
PhylomeDBiQ9JKM7

Miscellaneous databases

PROiPR:Q9JKM7
SOURCEiSearch...

Gene expression databases

CleanExiMM_RAB37

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB37_MOUSE
AccessioniPrimary (citable) accession number: Q9JKM7
Secondary accession number(s): Q8C7E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: April 26, 2004
Last modified: November 7, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again