Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

Gene

Ndufaf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
Alternative name(s):
Protein 2P1
Gene namesi
Name:Ndufaf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1913956 Ndufaf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002811551 – 185NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3Add BLAST185

Proteomic databases

EPDiQ9JKL4
MaxQBiQ9JKL4
PaxDbiQ9JKL4
PeptideAtlasiQ9JKL4
PRIDEiQ9JKL4

PTM databases

PhosphoSitePlusiQ9JKL4

Expressioni

Tissue specificityi

Strongly expressed in testis and weakly expressed in the epididymis. Expressed in spermatocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000070283
CleanExiMM_4733401H18RIK
ExpressionAtlasiQ9JKL4 baseline and differential
GenevisibleiQ9JKL4 MM

Interactioni

Subunit structurei

Interacts with NDUFAF4, NDUFS2 and NDUFS3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073832

Structurei

3D structure databases

ProteinModelPortaliQ9JKL4
SMRiQ9JKL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3363 Eukaryota
ENOG4111J7F LUCA
GeneTreeiENSGT00390000018312
HOGENOMiHOG000261143
InParanoidiQ9JKL4
KOiK09008
OMAiMYIDSYS
OrthoDBiEOG091G0O8P
PhylomeDBiQ9JKL4
TreeFamiTF321072

Family and domain databases

CDDicd05125 Mth938_2P1-like, 1 hit
Gene3Di3.40.1230.10, 1 hit
InterProiView protein in InterPro
IPR036748 MTH938-like_sf
IPR034095 NDUF3
IPR007523 NDUFAF3/AAMDC
PANTHERiPTHR21192 PTHR21192, 1 hit
PfamiView protein in Pfam
PF04430 DUF498, 1 hit
SUPFAMiSSF64076 SSF64076, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JKL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATALGFRCL FRTRPAPLCR HVDRLWRNPR RGHRLSPADD ELYQRTRISL
60 70 80 90 100
LQSEFPQAVY IDSYSSRGFT ICGNRVFGPC VLLPQTVVQW NVGSHQDITE
110 120 130 140 150
ESFSLFWMLE PRIEIVVVGT GNKTERLHPQ VLQAMRQRGI AVEVQDTPNA
160 170 180
CATFNFLCHE GRVTGAALIP PPGETALASL GQASE
Length:185
Mass (Da):20,734
Last modified:October 1, 2000 - v1
Checksum:iEB2095864254B757
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89Q → H in AAH27513 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235017 mRNA Translation: AAF61723.1
AK005252 mRNA Translation: BAB23907.1
AK014634 mRNA Translation: BAB29477.1
BC027513 mRNA Translation: AAH27513.1
CCDSiCCDS23531.1
RefSeqiNP_075736.1, NM_023247.1
UniGeneiMm.29471

Genome annotation databases

EnsembliENSMUST00000074208; ENSMUSP00000073832; ENSMUSG00000070283
GeneIDi66706
KEGGimmu:66706
UCSCiuc009rqh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNDUF3_MOUSE
AccessioniPrimary (citable) accession number: Q9JKL4
Secondary accession number(s): Q8K1A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health