UniProtKB - Q9JKL1 (PKR1_MOUSE)
Protein
Prokineticin receptor 1
Gene
Prokr1
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity).By similarity
GO - Molecular functioni
- G protein-coupled receptor activity Source: MGI
- neuropeptide Y receptor activity Source: InterPro
GO - Biological processi
- circadian rhythm Source: MGI
- coronary vasculature development Source: DFLAT
- G protein-coupled receptor signaling pathway Source: GO_Central
- negative regulation of apoptotic process Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-416476, G alpha (q) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Prokineticin receptor 1Short name: PK-R1 Alternative name(s): G-protein coupled receptor 73 |
Gene namesi | Name:Prokr1 Synonyms:Gpr73, Pkr1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1929676, Prokr1 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 62 | ExtracellularSequence analysisAdd BLAST | 62 | |
Transmembranei | 63 – 83 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 84 – 98 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 99 – 119 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 120 – 146 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 147 – 167 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 168 – 179 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 180 – 200 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 201 – 232 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 233 – 253 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 254 – 282 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 283 – 303 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 304 – 322 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 323 – 343 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 344 – 393 | CytoplasmicSequence analysisAdd BLAST | 50 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070080 | 1 – 393 | Prokineticin receptor 1Add BLAST | 393 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 137 ↔ 217 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9JKL1 |
PRIDEi | Q9JKL1 |
PTM databases
GlyGeni | Q9JKL1, 1 site |
iPTMneti | Q9JKL1 |
PhosphoSitePlusi | Q9JKL1 |
Expressioni
Tissue specificityi
Expressed at high levels in the heart, skeletal muscle and pancreas. Expressed at lower levels in the brain, lung, liver and kidney.
Gene expression databases
Bgeei | ENSMUSG00000049409, Expressed in blood and 139 other tissues |
ExpressionAtlasi | Q9JKL1, baseline and differential |
Genevisiblei | Q9JKL1, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000059034 |
Miscellaneous databases
RNActi | Q9JKL1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000164891 |
HOGENOMi | CLU_009579_6_0_1 |
InParanoidi | Q9JKL1 |
OMAi | ILRLQWR |
OrthoDBi | 664455at2759 |
TreeFami | TF315303 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000611, NPY_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01012, NRPEPTIDEYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9JKL1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METTVGALGE NTTDTFTDFF SALDGHEAQT GSLPFTFSYG DYDMPLDEEE
60 70 80 90 100
DVTNSRTFFA AKIVIGMALV GIMLVCGIGN FIFITALARY KKLRNLTNLL
110 120 130 140 150
IANLAISDFL VAIVCCPFEM DYYVVRQLSW EHGHVLCASV NYLRTVSLYV
160 170 180 190 200
STNALLAIAI DRYLAIVHPL RPRMKCQTAA GLIFLVWSVS ILIAIPAAYF
210 220 230 240 250
TTETVLVIVE RQEKIFCGQI WPVDQQFYYR SYFLLVFGLE FVGPVVAMTL
260 270 280 290 300
CYARVSRELW FKAVPGFQTE QIRRRLRCRR RTVLGLVCVL SAYVLCWAPF
310 320 330 340 350
YGFTIVRDFF PSVFVKEKHY LTAFYVVECI AMSNSMINTL CFVTVRNNTS
360 370 380 390
KYLKRILRLQ WRASPSGSKA SADLDLRTTG IPATEEVDCI RLK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0N4SWD5 | A0A0N4SWD5_MOUSE | Prokineticin receptor 1 | Prokr1 | 114 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 275 – 276 | RL → TV in AAF43706 (PubMed:10760605).Curated | 2 | |
Sequence conflicti | 275 – 276 | RL → TV in AAM49570 (PubMed:12024206).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF236082 mRNA Translation: AAF43706.1 AF487278 mRNA Translation: AAM49570.1 AK134279 mRNA Translation: BAE22080.1 AK156734 mRNA Translation: BAE33828.1 CH466523 Genomic DNA Translation: EDK99210.1 BC059003 mRNA Translation: AAH59003.1 |
CCDSi | CCDS20323.1 |
RefSeqi | NP_067356.2, NM_021381.3 XP_006506494.1, XM_006506431.3 XP_006506495.1, XM_006506432.3 |
Genome annotation databases
Ensembli | ENSMUST00000050887; ENSMUSP00000059034; ENSMUSG00000049409 ENSMUST00000204682; ENSMUSP00000144999; ENSMUSG00000049409 |
GeneIDi | 58182 |
KEGGi | mmu:58182 |
UCSCi | uc009cto.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF236082 mRNA Translation: AAF43706.1 AF487278 mRNA Translation: AAM49570.1 AK134279 mRNA Translation: BAE22080.1 AK156734 mRNA Translation: BAE33828.1 CH466523 Genomic DNA Translation: EDK99210.1 BC059003 mRNA Translation: AAH59003.1 |
CCDSi | CCDS20323.1 |
RefSeqi | NP_067356.2, NM_021381.3 XP_006506494.1, XM_006506431.3 XP_006506495.1, XM_006506432.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000059034 |
Chemistry databases
ChEMBLi | CHEMBL1949486 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9JKL1, 1 site |
iPTMneti | Q9JKL1 |
PhosphoSitePlusi | Q9JKL1 |
Proteomic databases
PaxDbi | Q9JKL1 |
PRIDEi | Q9JKL1 |
Genome annotation databases
Ensembli | ENSMUST00000050887; ENSMUSP00000059034; ENSMUSG00000049409 ENSMUST00000204682; ENSMUSP00000144999; ENSMUSG00000049409 |
GeneIDi | 58182 |
KEGGi | mmu:58182 |
UCSCi | uc009cto.1, mouse |
Organism-specific databases
CTDi | 10887 |
MGIi | MGI:1929676, Prokr1 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000164891 |
HOGENOMi | CLU_009579_6_0_1 |
InParanoidi | Q9JKL1 |
OMAi | ILRLQWR |
OrthoDBi | 664455at2759 |
TreeFami | TF315303 |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-416476, G alpha (q) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 58182, 1 hit in 17 CRISPR screens |
PROi | PR:Q9JKL1 |
RNActi | Q9JKL1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000049409, Expressed in blood and 139 other tissues |
ExpressionAtlasi | Q9JKL1, baseline and differential |
Genevisiblei | Q9JKL1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000611, NPY_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01012, NRPEPTIDEYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PKR1_MOUSE | |
Accessioni | Q9JKL1Primary (citable) accession number: Q9JKL1 Secondary accession number(s): Q3U0M4, Q6PD11 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2003 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries