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Protein

Prokineticin receptor 1

Gene

Prokr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • blood circulation Source: GO_Central
  • chemical synaptic transmission Source: GO_Central
  • circadian rhythm Source: MGI
  • coronary vasculature development Source: DFLAT
  • feeding behavior Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • neuropeptide signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prokineticin receptor 1
Short name:
PK-R1
Alternative name(s):
G-protein coupled receptor 73
Gene namesi
Name:Prokr1
Synonyms:Gpr73, Pkr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1929676 Prokr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62ExtracellularSequence analysisAdd BLAST62
Transmembranei63 – 83Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini84 – 98CytoplasmicSequence analysisAdd BLAST15
Transmembranei99 – 119Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini120 – 146ExtracellularSequence analysisAdd BLAST27
Transmembranei147 – 167Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini168 – 179CytoplasmicSequence analysisAdd BLAST12
Transmembranei180 – 200Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini201 – 232ExtracellularSequence analysisAdd BLAST32
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini254 – 282CytoplasmicSequence analysisAdd BLAST29
Transmembranei283 – 303Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini304 – 322ExtracellularSequence analysisAdd BLAST19
Transmembranei323 – 343Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini344 – 393CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1949486

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700801 – 393Prokineticin receptor 1Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi137 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JKL1
PRIDEiQ9JKL1

PTM databases

iPTMnetiQ9JKL1
PhosphoSitePlusiQ9JKL1

Expressioni

Tissue specificityi

Expressed at high levels in the heart, skeletal muscle and pancreas. Expressed at lower levels in the brain, lung, liver and kidney.

Gene expression databases

BgeeiENSMUSG00000049409
CleanExiMM_PROKR1
ExpressionAtlasiQ9JKL1 baseline and differential
GenevisibleiQ9JKL1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059034

Structurei

3D structure databases

ProteinModelPortaliQ9JKL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00920000148949
HOGENOMiHOG000231664
HOVERGENiHBG039631
InParanoidiQ9JKL1
KOiK08379
OMAiNFIFITA
OrthoDBiEOG091G086Y
TreeFamiTF315303

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000611 NPY_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01012 NRPEPTIDEYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JKL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METTVGALGE NTTDTFTDFF SALDGHEAQT GSLPFTFSYG DYDMPLDEEE
60 70 80 90 100
DVTNSRTFFA AKIVIGMALV GIMLVCGIGN FIFITALARY KKLRNLTNLL
110 120 130 140 150
IANLAISDFL VAIVCCPFEM DYYVVRQLSW EHGHVLCASV NYLRTVSLYV
160 170 180 190 200
STNALLAIAI DRYLAIVHPL RPRMKCQTAA GLIFLVWSVS ILIAIPAAYF
210 220 230 240 250
TTETVLVIVE RQEKIFCGQI WPVDQQFYYR SYFLLVFGLE FVGPVVAMTL
260 270 280 290 300
CYARVSRELW FKAVPGFQTE QIRRRLRCRR RTVLGLVCVL SAYVLCWAPF
310 320 330 340 350
YGFTIVRDFF PSVFVKEKHY LTAFYVVECI AMSNSMINTL CFVTVRNNTS
360 370 380 390
KYLKRILRLQ WRASPSGSKA SADLDLRTTG IPATEEVDCI RLK
Length:393
Mass (Da):44,597
Last modified:July 27, 2011 - v2
Checksum:iD0F5E79606D74283
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti275 – 276RL → TV in AAF43706 (PubMed:10760605).Curated2
Sequence conflicti275 – 276RL → TV in AAM49570 (PubMed:12024206).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236082 mRNA Translation: AAF43706.1
AF487278 mRNA Translation: AAM49570.1
AK134279 mRNA Translation: BAE22080.1
AK156734 mRNA Translation: BAE33828.1
CH466523 Genomic DNA Translation: EDK99210.1
BC059003 mRNA Translation: AAH59003.1
CCDSiCCDS20323.1
RefSeqiNP_067356.2, NM_021381.3
XP_006506494.1, XM_006506431.3
XP_006506495.1, XM_006506432.3
UniGeneiMm.333226

Genome annotation databases

EnsembliENSMUST00000050887; ENSMUSP00000059034; ENSMUSG00000049409
ENSMUST00000204682; ENSMUSP00000144999; ENSMUSG00000049409
GeneIDi58182
KEGGimmu:58182
UCSCiuc009cto.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPKR1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKL1
Secondary accession number(s): Q3U0M4, Q6PD11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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