UniProtKB - Q9JKK7 (TMOD2_MOUSE)
Protein
Tropomodulin-2
Gene
Tmod2
Organism
Mus musculus (Mouse)
Status
Functioni
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).By similarity
GO - Molecular functioni
- actin binding Source: MGI
- tropomyosin binding Source: MGI
GO - Biological processi
- actin filament organization Source: GO_Central
- learning or memory Source: MGI
- muscle contraction Source: GO_Central
- myofibril assembly Source: GO_Central
- neuron-neuron synaptic transmission Source: MGI
- pointed-end actin filament capping Source: InterPro
- positive regulation of G protein-coupled receptor signaling pathway Source: MGI
Keywordsi
Molecular function | Actin-binding |
Enzyme and pathway databases
Reactomei | R-MMU-390522, Striated Muscle Contraction |
Names & Taxonomyi
Protein namesi | Recommended name: Tropomodulin-2Alternative name(s): Neuronal tropomodulin Short name: N-Tmod |
Gene namesi | Name:Tmod2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1355335, Tmod2 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- cytoskeleton Source: GO_Central
- striated muscle thin filament Source: GO_Central
Other locations
- growth cone Source: MGI
- myofibril Source: GO_Central
- neuron projection Source: MGI
- synapse Source: GOC
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186132 | 1 – 351 | Tropomodulin-2Add BLAST | 351 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9JKK7 |
PaxDbi | Q9JKK7 |
PeptideAtlasi | Q9JKK7 |
PRIDEi | Q9JKK7 |
PTM databases
iPTMneti | Q9JKK7 |
PhosphoSitePlusi | Q9JKK7 |
Expressioni
Tissue specificityi
Neuronal-tissue specific.
Gene expression databases
Bgeei | ENSMUSG00000032186, Expressed in Ammon's horn and 231 other tissues |
ExpressionAtlasi | Q9JKK7, baseline and differential |
Genevisiblei | Q9JKK7, MM |
Interactioni
Subunit structurei
Binds to the N-terminus of tropomyosin and to actin.
GO - Molecular functioni
- actin binding Source: MGI
- tropomyosin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 206139, 5 interactors |
IntActi | Q9JKK7, 5 interactors |
MINTi | Q9JKK7 |
STRINGi | 10090.ENSMUSP00000096152 |
Miscellaneous databases
RNActi | Q9JKK7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the tropomodulin family.Curated
Phylogenomic databases
eggNOGi | KOG3735, Eukaryota |
GeneTreei | ENSGT00940000160631 |
HOGENOMi | CLU_031052_0_1_1 |
InParanoidi | Q9JKK7 |
OMAi | HNLVNNP |
OrthoDBi | 1025132at2759 |
PhylomeDBi | Q9JKK7 |
TreeFami | TF315841 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR032675, LRR_dom_sf IPR004934, TMOD IPR030130, TMOD2 |
PANTHERi | PTHR10901, PTHR10901, 1 hit PTHR10901:SF15, PTHR10901:SF15, 1 hit |
Pfami | View protein in Pfam PF03250, Tropomodulin, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9JKK7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALPFQKGLE KYKNIDEDEL LGKLSEEELK QLENVLDDLD PESATLPAGF
60 70 80 90 100
RQKDQTQKAA TGPFDREHLL MYLEKEALEQ KDREDFVPFT GEKKGRVFIP
110 120 130 140 150
KEKPVETRKE EKVTLDPELE EALASASDTE LYDLAAVLGV HNLLNNPKFD
160 170 180 190 200
EETTNGEGRK GPVRNVVKGE KAKPVFEEPP NPTNVEASLQ QMKANDPSLQ
210 220 230 240 250
EVNLNNIKNI PIPTLKEFAK SLETNTHVKK FSLAATRSND PVALAFAEML
260 270 280 290 300
KVNKTLKSLN VESNFITGTG ILALVEALRE NDTLTEIKID NQRQQLGTAV
310 320 330 340 350
EMEIAQMLEE NSRILKFGYQ FTKQGPRTRV AAAITKNNDL VRKKRVEGDR
R
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1L1SRR7 | A0A1L1SRR7_MOUSE | Tropomodulin-2 | Tmod2 | 131 | Annotation score: | ||
A0A1L1SU70 | A0A1L1SU70_MOUSE | Tropomodulin-2 | Tmod2 | 248 | Annotation score: | ||
A0A1L1ST54 | A0A1L1ST54_MOUSE | Tropomodulin-2 | Tmod2 | 9 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 – 27 | EE → KR in BAB29946 (PubMed:16141072).Curated | 2 | |
Sequence conflicti | 42 | E → K in BAB29946 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 157 | E → Q in AAF45297 (Ref. 1) Curated | 1 | |
Sequence conflicti | 263 | S → F in AAF31669 (PubMed:10662549).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024895 | 1 – 191 | Missing in isoform 3. 1 PublicationAdd BLAST | 191 | |
Alternative sequenceiVSP_024896 | 165 – 240 | NVVKG…TRSND → SKLTRALGAWEVPEPAWCMF HQAQCLVSASPSVVTQGTQS YRTHIRGTSSSGEKKSIPDK FAQSAQNANKVFCSKG in isoform 2. 1 PublicationAdd BLAST | 76 | |
Alternative sequenceiVSP_024897 | 241 – 351 | Missing in isoform 2. 1 PublicationAdd BLAST | 111 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF237629 mRNA Translation: AAF45297.1 AF177170 mRNA Translation: AAF31669.1 AK015719 mRNA Translation: BAB29946.3 AK076562 mRNA Translation: BAC36394.1 AK079077 mRNA Translation: BAC37527.1 AK147581 mRNA Translation: BAE28007.1 AK164178 mRNA Translation: BAE37665.1 BC061124 mRNA Translation: AAH61124.1 |
CCDSi | CCDS23345.1 [Q9JKK7-1] |
RefSeqi | NP_001033799.1, NM_001038710.1 [Q9JKK7-1] NP_057920.2, NM_016711.3 [Q9JKK7-1] XP_006511330.1, XM_006511267.3 [Q9JKK7-1] XP_006511331.1, XM_006511268.2 [Q9JKK7-1] XP_017168948.1, XM_017313459.1 [Q9JKK7-1] XP_017168949.1, XM_017313460.1 |
Genome annotation databases
Ensembli | ENSMUST00000064433; ENSMUSP00000069956; ENSMUSG00000032186 [Q9JKK7-1] ENSMUST00000098552; ENSMUSP00000096152; ENSMUSG00000032186 [Q9JKK7-1] ENSMUST00000164100; ENSMUSP00000126739; ENSMUSG00000032186 [Q9JKK7-1] ENSMUST00000215036; ENSMUSP00000150750; ENSMUSG00000032186 [Q9JKK7-1] ENSMUST00000215614; ENSMUSP00000150413; ENSMUSG00000032186 [Q9JKK7-1] |
GeneIDi | 50876 |
KEGGi | mmu:50876 |
UCSCi | uc009qsj.1, mouse [Q9JKK7-1] uc009qsp.1, mouse [Q9JKK7-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF237629 mRNA Translation: AAF45297.1 AF177170 mRNA Translation: AAF31669.1 AK015719 mRNA Translation: BAB29946.3 AK076562 mRNA Translation: BAC36394.1 AK079077 mRNA Translation: BAC37527.1 AK147581 mRNA Translation: BAE28007.1 AK164178 mRNA Translation: BAE37665.1 BC061124 mRNA Translation: AAH61124.1 |
CCDSi | CCDS23345.1 [Q9JKK7-1] |
RefSeqi | NP_001033799.1, NM_001038710.1 [Q9JKK7-1] NP_057920.2, NM_016711.3 [Q9JKK7-1] XP_006511330.1, XM_006511267.3 [Q9JKK7-1] XP_006511331.1, XM_006511268.2 [Q9JKK7-1] XP_017168948.1, XM_017313459.1 [Q9JKK7-1] XP_017168949.1, XM_017313460.1 |
3D structure databases
SMRi | Q9JKK7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 206139, 5 interactors |
IntActi | Q9JKK7, 5 interactors |
MINTi | Q9JKK7 |
STRINGi | 10090.ENSMUSP00000096152 |
PTM databases
iPTMneti | Q9JKK7 |
PhosphoSitePlusi | Q9JKK7 |
Proteomic databases
EPDi | Q9JKK7 |
PaxDbi | Q9JKK7 |
PeptideAtlasi | Q9JKK7 |
PRIDEi | Q9JKK7 |
Protocols and materials databases
Antibodypediai | 24900, 177 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000064433; ENSMUSP00000069956; ENSMUSG00000032186 [Q9JKK7-1] ENSMUST00000098552; ENSMUSP00000096152; ENSMUSG00000032186 [Q9JKK7-1] ENSMUST00000164100; ENSMUSP00000126739; ENSMUSG00000032186 [Q9JKK7-1] ENSMUST00000215036; ENSMUSP00000150750; ENSMUSG00000032186 [Q9JKK7-1] ENSMUST00000215614; ENSMUSP00000150413; ENSMUSG00000032186 [Q9JKK7-1] |
GeneIDi | 50876 |
KEGGi | mmu:50876 |
UCSCi | uc009qsj.1, mouse [Q9JKK7-1] uc009qsp.1, mouse [Q9JKK7-2] |
Organism-specific databases
CTDi | 29767 |
MGIi | MGI:1355335, Tmod2 |
Phylogenomic databases
eggNOGi | KOG3735, Eukaryota |
GeneTreei | ENSGT00940000160631 |
HOGENOMi | CLU_031052_0_1_1 |
InParanoidi | Q9JKK7 |
OMAi | HNLVNNP |
OrthoDBi | 1025132at2759 |
PhylomeDBi | Q9JKK7 |
TreeFami | TF315841 |
Enzyme and pathway databases
Reactomei | R-MMU-390522, Striated Muscle Contraction |
Miscellaneous databases
BioGRID-ORCSi | 50876, 2 hits in 17 CRISPR screens |
ChiTaRSi | Tmod2, mouse |
PROi | PR:Q9JKK7 |
RNActi | Q9JKK7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032186, Expressed in Ammon's horn and 231 other tissues |
ExpressionAtlasi | Q9JKK7, baseline and differential |
Genevisiblei | Q9JKK7, MM |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR032675, LRR_dom_sf IPR004934, TMOD IPR030130, TMOD2 |
PANTHERi | PTHR10901, PTHR10901, 1 hit PTHR10901:SF15, PTHR10901:SF15, 1 hit |
Pfami | View protein in Pfam PF03250, Tropomodulin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TMOD2_MOUSE | |
Accessioni | Q9JKK7Primary (citable) accession number: Q9JKK7 Secondary accession number(s): Q3UH50 Q9JLH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | May 1, 2007 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families