UniProtKB - Q9JKK1 (STX6_MOUSE)
Syntaxin-6
Stx6
Functioni
GO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: GO_Central
- syntaxin binding Source: MGI
GO - Biological processi
- endocytic recycling Source: MGI
- endosome organization Source: MGI
- Golgi ribbon formation Source: MGI
- Golgi vesicle transport Source: InterPro
- intracellular protein transport Source: GO_Central
- regulation of cellular protein localization Source: AgBase
- regulation of protein localization Source: MGI
- retrograde transport, endosome to Golgi Source: MGI
- synaptic vesicle to endosome fusion Source: MGI
- vesicle docking Source: GO_Central
- vesicle fusion Source: MGI
- vesicle-mediated transport Source: MGI
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-6811438, Intra-Golgi traffic R-MMU-6811440, Retrograde transport at the Trans-Golgi-Network |
Names & Taxonomyi
Protein namesi | Recommended name: Syntaxin-6 |
Gene namesi | Name:Stx6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1926235, Stx6 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Single-pass type IV membrane protein By similarity
Cytosol
- cytosol Source: MGI
Endosome
- early endosome Source: MGI
- recycling endosome Source: MGI
Golgi apparatus
- Golgi apparatus Source: MGI
- trans-Golgi network Source: MGI
- trans-Golgi network membrane Source: MGI
Nucleus
- nucleoplasm Source: MGI
Other locations
- endomembrane system Source: GO_Central
- integral component of membrane Source: MGI
- integral component of synaptic vesicle membrane Source: MGI
- membrane Source: MGI
- perinuclear region of cytoplasm Source: MGI
- phagocytic vesicle Source: AgBase
- SNARE complex Source: MGI
- synaptic vesicle Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 234 | CytoplasmicSequence analysisAdd BLAST | 233 | |
Transmembranei | 235 – 255 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000210209 | 2 – 255 | Syntaxin-6Add BLAST | 254 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 129 | PhosphoserineBy similarity | 1 | |
Modified residuei | 152 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q9JKK1 |
PaxDbi | Q9JKK1 |
PRIDEi | Q9JKK1 |
PTM databases
iPTMneti | Q9JKK1 |
PhosphoSitePlusi | Q9JKK1 |
SwissPalmi | Q9JKK1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000026470, Expressed in external carotid artery and 299 other tissues |
Genevisiblei | Q9JKK1, MM |
Interactioni
Subunit structurei
Identified in a complex containing STX6, STX12 and VAMP4 (By similarity). This complex also includes VTI1A (PubMed:9705316). Binds EEA1 (By similarity).
Interacts with VPS45A and GOPC (By similarity).
Interacts with MARCHF2 and MARCHF3 (By similarity).
Interacts with UHRF1BP1L (via C-terminal coiled-coil domain) (By similarity).
Interacts with BAIAP3; this interaction is increased in the presence of calcium (By similarity).
By similarity1 PublicationGO - Molecular functioni
- SNARE binding Source: GO_Central
- syntaxin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 208415, 11 interactors |
CORUMi | Q9JKK1 |
IntActi | Q9JKK1, 5 interactors |
MINTi | Q9JKK1 |
STRINGi | 10090.ENSMUSP00000027743 |
Miscellaneous databases
RNActi | Q9JKK1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 163 – 225 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 41 – 74 | Sequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3202, Eukaryota |
GeneTreei | ENSGT00940000157639 |
HOGENOMi | CLU_061883_1_0_1 |
InParanoidi | Q9JKK1 |
OMAi | HEMDSTQ |
OrthoDBi | 1563292at2759 |
PhylomeDBi | Q9JKK1 |
TreeFami | TF313254 |
Family and domain databases
InterProi | View protein in InterPro IPR010989, SNARE IPR015260, Syntaxin-6_N IPR006012, Syntaxin/epimorphin_CS IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF09177, Syntaxin-6_N, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQGPSAATR EEIDWTTNEL
60 70 80 90 100
RNNLRSIEWD LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQIVR
110 120 130 140 150
DMKDQMSASS VQALAERKNR QALLGDSSSQ SWNAGVADRY GRLDRELQLA
160 170 180 190 200
NSHFIEEQQA QQQLIVEQQD EQLELVSGSI GVLKNMSQRI GGELEEQAVM
210 220 230 240 250
LDDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI LFAVLVVVLI
LFLVL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A6YW23 | A0A0A6YW23_MOUSE | Syntaxin-6 | Stx6 | 91 | Annotation score: | ||
A0A0A6YXG0 | A0A0A6YXG0_MOUSE | Syntaxin-6 | Stx6 | 199 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016138 | 231 – 255 | DRRQW…LFLVL → GNDVRQVKIQYLLFIWRLLP GERKT in isoform 2. 1 PublicationAdd BLAST | 25 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF237814 mRNA Translation: AAF40221.1 AK009690 mRNA Translation: BAB26441.1 AK019106 mRNA Translation: BAB31549.1 AK031673 mRNA Translation: BAC27505.1 AK044905 mRNA Translation: BAC32135.1 AK049124 mRNA Translation: BAC33556.1 BC029205 mRNA Translation: AAH29205.1 |
CCDSi | CCDS35741.1 [Q9JKK1-1] |
RefSeqi | NP_067408.1, NM_021433.3 [Q9JKK1-1] |
Genome annotation databases
Ensembli | ENSMUST00000027743; ENSMUSP00000027743; ENSMUSG00000026470 [Q9JKK1-1] ENSMUST00000195302; ENSMUSP00000142089; ENSMUSG00000026470 [Q9JKK1-2] |
GeneIDi | 58244 |
KEGGi | mmu:58244 |
UCSCi | uc007dbb.1, mouse [Q9JKK1-1] uc007dbc.1, mouse [Q9JKK1-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF237814 mRNA Translation: AAF40221.1 AK009690 mRNA Translation: BAB26441.1 AK019106 mRNA Translation: BAB31549.1 AK031673 mRNA Translation: BAC27505.1 AK044905 mRNA Translation: BAC32135.1 AK049124 mRNA Translation: BAC33556.1 BC029205 mRNA Translation: AAH29205.1 |
CCDSi | CCDS35741.1 [Q9JKK1-1] |
RefSeqi | NP_067408.1, NM_021433.3 [Q9JKK1-1] |
3D structure databases
SMRi | Q9JKK1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 208415, 11 interactors |
CORUMi | Q9JKK1 |
IntActi | Q9JKK1, 5 interactors |
MINTi | Q9JKK1 |
STRINGi | 10090.ENSMUSP00000027743 |
PTM databases
iPTMneti | Q9JKK1 |
PhosphoSitePlusi | Q9JKK1 |
SwissPalmi | Q9JKK1 |
Proteomic databases
jPOSTi | Q9JKK1 |
PaxDbi | Q9JKK1 |
PRIDEi | Q9JKK1 |
Protocols and materials databases
Antibodypediai | 34430, 283 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000027743; ENSMUSP00000027743; ENSMUSG00000026470 [Q9JKK1-1] ENSMUST00000195302; ENSMUSP00000142089; ENSMUSG00000026470 [Q9JKK1-2] |
GeneIDi | 58244 |
KEGGi | mmu:58244 |
UCSCi | uc007dbb.1, mouse [Q9JKK1-1] uc007dbc.1, mouse [Q9JKK1-2] |
Organism-specific databases
CTDi | 10228 |
MGIi | MGI:1926235, Stx6 |
Phylogenomic databases
eggNOGi | KOG3202, Eukaryota |
GeneTreei | ENSGT00940000157639 |
HOGENOMi | CLU_061883_1_0_1 |
InParanoidi | Q9JKK1 |
OMAi | HEMDSTQ |
OrthoDBi | 1563292at2759 |
PhylomeDBi | Q9JKK1 |
TreeFami | TF313254 |
Enzyme and pathway databases
Reactomei | R-MMU-6811438, Intra-Golgi traffic R-MMU-6811440, Retrograde transport at the Trans-Golgi-Network |
Miscellaneous databases
BioGRID-ORCSi | 58244, 3 hits in 17 CRISPR screens |
ChiTaRSi | Stx6, mouse |
PROi | PR:Q9JKK1 |
RNActi | Q9JKK1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026470, Expressed in external carotid artery and 299 other tissues |
Genevisiblei | Q9JKK1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR010989, SNARE IPR015260, Syntaxin-6_N IPR006012, Syntaxin/epimorphin_CS IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF09177, Syntaxin-6_N, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STX6_MOUSE | |
Accessioni | Q9JKK1Primary (citable) accession number: Q9JKK1 Secondary accession number(s): Q9D3A1, Q9D729 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families