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Protein

Calcipressin-3

Gene

Rcan3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-3
Alternative name(s):
Down syndrome candidate region 1-like protein 2
Myocyte-enriched calcineurin-interacting protein 3
Short name:
MCIP3
Regulator of calcineurin 3
Gene namesi
Name:Rcan3
Synonyms:Dscr1l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1858220 Rcan3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114211 – 239Calcipressin-3Add BLAST239

Proteomic databases

EPDiQ9JKK0
MaxQBiQ9JKK0
PaxDbiQ9JKK0
PRIDEiQ9JKK0

PTM databases

iPTMnetiQ9JKK0
PhosphoSitePlusiQ9JKK0

Expressioni

Gene expression databases

BgeeiENSMUSG00000059713 Expressed in 263 organ(s), highest expression level in primary oocyte
CleanExiMM_RCAN3
ExpressionAtlasiQ9JKK0 baseline and differential
GenevisibleiQ9JKK0 MM

Interactioni

Subunit structurei

Interacts with protein phosphatase PPP3CA/calcineurin A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030606

Structurei

3D structure databases

ProteinModelPortaliQ9JKK0
SMRiQ9JKK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni183 – 203Calcineurin-bindingBy similarityAdd BLAST21

Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

eggNOGiKOG4019 Eukaryota
ENOG4111I50 LUCA
GeneTreeiENSGT00400000022053
HOGENOMiHOG000254788
HOVERGENiHBG018932
InParanoidiQ9JKK0
KOiK17905
OMAiFEVQEEK
OrthoDBiEOG091G0OZ7
PhylomeDBiQ9JKK0
TreeFamiTF313579

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034923 RCAN3
PANTHERiPTHR10300 PTHR10300, 1 hit
PTHR10300:SF6 PTHR10300:SF6, 1 hit
PfamiView protein in Pfam
PF04847 Calcipressin, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JKK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRDSLKSWN DSQSDLCSSD QEEEEEMVFG ENEDGLEEMM DLSDLPTSLF
60 70 80 90 100
ACSVHEAVFE VQEQKERFEA LFTLYDDQVT FQLFKSFRRV RINFSKPEAA
110 120 130 140 150
ARARIELHES EFHGRKLKLY FAQVQVSGEA RDKSYLLPPQ PTKQFLISPP
160 170 180 190 200
ASPPVGWKQS EDAMPVINYD LLCAVSKLGP GEKYELHAGT ESTPSVVVHV
210 220 230
CESETEEEED TKNPKQKITQ TRRPEAPTAA LSERLDCAL
Length:239
Mass (Da):27,153
Last modified:October 1, 2000 - v1
Checksum:i1B2687B47BB4D272
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A994A2A994_MOUSE
Calcipressin-3
Rcan3
159Annotation score:
B0QZL9B0QZL9_MOUSE
Calcipressin-3
Rcan3
137Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237888 mRNA Translation: AAF62539.1
AK019377 mRNA Translation: BAB31687.1
AK042201 mRNA Translation: BAE20626.1
AK155270 mRNA Translation: BAE33155.1
AL627185 Genomic DNA No translation available.
BC059001 mRNA Translation: AAH59001.1
CCDSiCCDS18785.1
RefSeqiNP_075356.1, NM_022980.4
XP_017175806.1, XM_017320317.1
UniGeneiMm.331970

Genome annotation databases

EnsembliENSMUST00000030606; ENSMUSP00000030606; ENSMUSG00000059713
GeneIDi53902
KEGGimmu:53902
UCSCiuc008vgm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237888 mRNA Translation: AAF62539.1
AK019377 mRNA Translation: BAB31687.1
AK042201 mRNA Translation: BAE20626.1
AK155270 mRNA Translation: BAE33155.1
AL627185 Genomic DNA No translation available.
BC059001 mRNA Translation: AAH59001.1
CCDSiCCDS18785.1
RefSeqiNP_075356.1, NM_022980.4
XP_017175806.1, XM_017320317.1
UniGeneiMm.331970

3D structure databases

ProteinModelPortaliQ9JKK0
SMRiQ9JKK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030606

PTM databases

iPTMnetiQ9JKK0
PhosphoSitePlusiQ9JKK0

Proteomic databases

EPDiQ9JKK0
MaxQBiQ9JKK0
PaxDbiQ9JKK0
PRIDEiQ9JKK0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030606; ENSMUSP00000030606; ENSMUSG00000059713
GeneIDi53902
KEGGimmu:53902
UCSCiuc008vgm.1 mouse

Organism-specific databases

CTDi11123
MGIiMGI:1858220 Rcan3

Phylogenomic databases

eggNOGiKOG4019 Eukaryota
ENOG4111I50 LUCA
GeneTreeiENSGT00400000022053
HOGENOMiHOG000254788
HOVERGENiHBG018932
InParanoidiQ9JKK0
KOiK17905
OMAiFEVQEEK
OrthoDBiEOG091G0OZ7
PhylomeDBiQ9JKK0
TreeFamiTF313579

Miscellaneous databases

ChiTaRSiRcan3 mouse
PROiPR:Q9JKK0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059713 Expressed in 263 organ(s), highest expression level in primary oocyte
CleanExiMM_RCAN3
ExpressionAtlasiQ9JKK0 baseline and differential
GenevisibleiQ9JKK0 MM

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034923 RCAN3
PANTHERiPTHR10300 PTHR10300, 1 hit
PTHR10300:SF6 PTHR10300:SF6, 1 hit
PfamiView protein in Pfam
PF04847 Calcipressin, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRCAN3_MOUSE
AccessioniPrimary (citable) accession number: Q9JKK0
Secondary accession number(s): Q3U2I5, Q9CX87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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