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Protein

Nectin-1

Gene

Nectin1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cell adhesion and synaptogegesis. Has some neurite outgrowth-promoting activity. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processCell adhesion, Host-virus interaction

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions
R-MMU-420597 Nectin/Necl trans heterodimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Nectin-1
Alternative name(s):
Herpes virus entry mediator C
Short name:
Herpesvirus entry mediator C
Short name:
HveC
Nectin cell adhesion molecule 1By similarity
Poliovirus receptor-related protein 1
CD_antigen: CD111
Gene namesi
Name:Nectin1By similarity
Synonyms:Hvec, Prr1, Pvrl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1926483 Nectin1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 354ExtracellularSequence analysisAdd BLAST324
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 515CytoplasmicSequence analysisAdd BLAST140

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001513431 – 515Nectin-1Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi51 ↔ 124PROSITE-ProRule annotation
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 226PROSITE-ProRule annotation
Glycosylationi200N-linked (GlcNAc...) asparagine; atypical1 Publication1
Glycosylationi202N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi269 ↔ 316PROSITE-ProRule annotation1 Publication
Glycosylationi274N-linked (GlcNAc...) asparagine; atypical1 Publication1
Glycosylationi286N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi332N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei421PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei435PhosphotyrosineCombined sources1
Modified residuei509PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9JKF6
PaxDbiQ9JKF6
PeptideAtlasiQ9JKF6
PRIDEiQ9JKF6

PTM databases

iPTMnetiQ9JKF6
PhosphoSitePlusiQ9JKF6

Expressioni

Gene expression databases

BgeeiENSMUSG00000032012 Expressed in 149 organ(s), highest expression level in liver
CleanExiMM_PVRL1
ExpressionAtlasiQ9JKF6 baseline and differential
GenevisibleiQ9JKF6 MM

Interactioni

Subunit structurei

Cis- and trans-homodimer. Can form trans-heterodimers with NECTIN3. Interaction between NECTIN1 and NECTIN3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Ig-like C2-type domain 2) with FGFR1, FGFR2 and FGFR3. Interacts (via Cytoplasmic domain) with AFDN, providing a connection with the actin cytoskeleton. Interacts with HSV glycoprotein D (gD).3 Publications

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-41728N
MINTiQ9JKF6
STRINGi10090.ENSMUSP00000034510

Structurei

Secondary structure

1515
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9JKF6
SMRiQ9JKF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 141Ig-like V-typeAdd BLAST111
Domaini145 – 243Ig-like C2-type 1Add BLAST99
Domaini247 – 334Ig-like C2-type 2Add BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni282 – 299Interaction with FGFRAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi436 – 442Poly-Glu7
Compositional biasi443 – 447Poly-Gly5

Domaini

Ig-like C2-type 2 mediates neurite outgrowth through binding, induction of phosphorylation, and activation of FGFR.

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF17 Eukaryota
ENOG410YK75 LUCA
GeneTreeiENSGT00900000140811
HOGENOMiHOG000115804
HOVERGENiHBG100542
InParanoidiQ9JKF6
KOiK06081
OMAiEVNVTEF
OrthoDBiEOG091G0BLQ
TreeFamiTF331051

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR033314 Nectin1
PANTHERiPTHR23277:SF69 PTHR23277:SF69, 1 hit
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9JKF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARMGLAGAA GRWWGLALGL TAFFLPGTHT QVVQVNDSMY GFIGTDVVLH
60 70 80 90 100
CSFANPLPSV KITQVTWQKA SNGSKQNMAI YNPTMGVSVL PPYEKRVEFL
110 120 130 140 150
RPSFIDGTIR LSGLELEDEG MYICEFATFP TGNRESQLNL TVMAKPTNWI
160 170 180 190 200
EGTRAVLRAR KGQDDKVLVA TCTSANGKPP SAVSWETRLK GEAEYQEIRN
210 220 230 240 250
PNGTVTVISR YRLVPSREAH RQSLACIVNY HLDRFRESLT LNVQYEPEVT
260 270 280 290 300
IEGFDGNWYL QRTDVKLTCK ADANPPATEY HWTTLNGSLP KGVEAQNRTL
310 320 330 340 350
FFRGPITYSL AGTYICEATN PIGTRSGQVE VNITEFPYTP TPEHGRRAGQ
360 370 380 390 400
MPTAIIGGVA GSVLLVLIVV GGIIVALRRR RHTFKGDYST KKHVYGNGYS
410 420 430 440 450
KAGIPQHHPP MAQNLQYPDD SDDEKKAGPL GGSSYEEEEE EEGGGGGERK
460 470 480 490 500
VGGPHPKYDE DAKRPYFTVD EAEARQDGYG DRTLGYQYDP EQLDLAENMV
510
SQNDGSFISK KEWYV
Length:515
Mass (Da):57,035
Last modified:July 27, 2011 - v3
Checksum:iA56FA2C7F8B25AFB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SQP1A0A1L1SQP1_MOUSE
Nectin-1
Nectin1
114Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138L → P in AAF60333 (PubMed:10781093).Curated1
Sequence conflicti165D → N in AAF76195 (PubMed:11090177).Curated1
Sequence conflicti165D → N in AAG22808 (Ref. 3) Curated1
Sequence conflicti342P → PP in AAF76195 (PubMed:11090177).Curated1
Sequence conflicti428G → S in AAF60333 (PubMed:10781093).Curated1
Sequence conflicti428G → S in AAF76195 (PubMed:11090177).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239762 mRNA Translation: AAF60333.1
AF270977 mRNA Translation: AAF76195.1
AF297665 mRNA Translation: AAG22808.1
BC060694 mRNA Translation: AAH60694.1
CCDSiCCDS23092.1
RefSeqiNP_067399.2, NM_021424.2
UniGeneiMm.335096

Genome annotation databases

EnsembliENSMUST00000034510; ENSMUSP00000034510; ENSMUSG00000032012
GeneIDi58235
KEGGimmu:58235
UCSCiuc009pbj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNECT1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKF6
Secondary accession number(s): Q6P9M9, Q9ERL5, Q9JI17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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