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Protein

Ras GTPase-activating-like protein IQGAP1

Gene

Iqgap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity (PubMed:16968698). It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to calcium ion Source: MGI
  • cellular response to epidermal growth factor stimulus Source: BHF-UCL
  • cellular response to fibroblast growth factor stimulus Source: BHF-UCL
  • cellular response to platelet-derived growth factor stimulus Source: BHF-UCL
  • epidermal growth factor receptor signaling pathway Source: BHF-UCL
  • fibroblast growth factor receptor signaling pathway Source: BHF-UCL
  • glomerular visceral epithelial cell development Source: UniProtKB
  • negative regulation of dephosphorylation Source: MGI
  • neuron projection extension Source: MGI
  • platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
  • positive regulation of cellular protein localization Source: MGI
  • positive regulation of dendrite development Source: MGI
  • positive regulation of focal adhesion assembly Source: MGI
  • positive regulation of MAP kinase activity Source: MGI
  • positive regulation of peptidyl-tyrosine autophosphorylation Source: MGI
  • positive regulation of protein kinase activity Source: BHF-UCL
  • positive regulation of vascular associated smooth muscle cell migration Source: MGI
  • regulation of cytokine production Source: MGI
  • regulation of GTPase activity Source: InterPro
  • regulation of mitotic cell cycle Source: UniProtKB
  • response to angiotensin Source: Ensembl

Keywordsi

Molecular functionCalmodulin-binding

Enzyme and pathway databases

ReactomeiR-MMU-373753 Nephrin family interactions
R-MMU-5626467 RHO GTPases activate IQGAPs
R-MMU-5674135 MAP2K and MAPK activation
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating-like protein IQGAP1
Gene namesi
Name:Iqgap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1352757 Iqgap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000566492 – 1657Ras GTPase-activating-like protein IQGAP1Add BLAST1656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei172PhosphotyrosineCombined sources1
Modified residuei330PhosphoserineBy similarity1
Modified residuei1441PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9JKF1
MaxQBiQ9JKF1
PaxDbiQ9JKF1
PeptideAtlasiQ9JKF1
PRIDEiQ9JKF1

PTM databases

iPTMnetiQ9JKF1
PhosphoSitePlusiQ9JKF1
SwissPalmiQ9JKF1

Expressioni

Developmental stagei

Expressed widely in developing cortex.1 Publication

Gene expression databases

BgeeiENSMUSG00000030536
CleanExiMM_IQGAP1
ExpressionAtlasiQ9JKF1 baseline and differential
GenevisibleiQ9JKF1 MM

Interactioni

Subunit structurei

Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state (PubMed:16968698). Interacts with RAC1 (By similarity). Does not interact with RHOA (By similarity). Interacts with TSG101 (By similarity). Interacts with PAK6 (By similarity).By similarity1 Publication
(Microbial infection) In case of infection, interacts with S.typhimurium protein sseI (PubMed:19956712).1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205938, 13 interactors
CORUMiQ9JKF1
IntActiQ9JKF1, 16 interactors
MINTiQ9JKF1
STRINGi10090.ENSMUSP00000128278

Structurei

3D structure databases

ProteinModelPortaliQ9JKF1
SMRiQ9JKF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 159Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST116
Domaini685 – 710WWAdd BLAST26
Domaini745 – 774IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini775 – 804IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini805 – 834IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini835 – 864IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini1004 – 1237Ras-GAPPROSITE-ProRule annotationAdd BLAST234

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni956 – 1274C1Add BLAST319
Regioni1276 – 1657C2Add BLAST382

Domaini

Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2128 Eukaryota
COG5261 LUCA
GeneTreeiENSGT00600000084379
HOVERGENiHBG052143
InParanoidiQ9JKF1
KOiK16848
OMAiVDFRIGN
OrthoDBiEOG091G00ET
TreeFamiTF313078

Family and domain databases

CDDicd00014 CH, 1 hit
cd00201 WW, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase
IPR000593 RasGAP_C
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001202 WW_dom
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF00612 IQ, 4 hits
PF00616 RasGAP, 1 hit
PF03836 RasGAP_C, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00015 IQ, 4 hits
SM00323 RasGAP, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48350 SSF48350, 2 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS50096 IQ, 4 hits
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS01159 WW_DOMAIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAEEVDGL GVVRPHYGSV LDNERLTAEE MDERRRQNVA YEYLCHLEEA
60 70 80 90 100
KRWMEACLGE DLPPTTELEE GLRNGVYLAK LGNFFSPKVV SLKKIYDREQ
110 120 130 140 150
TRYKATGLHF RHTDNVIQWL NAMDEIGLPK IFYPETTDIY DRKNMPRCIY
160 170 180 190 200
CIHALSLYLF KLGLAPQIQD LYGKVDFTEE EINNMKIELE KYGIQMPAFS
210 220 230 240 250
KIGGILANEL SVDEAALHAA VIAINEAIDR RVAADTFTAL KNPNAMLVNL
260 270 280 290 300
EEGLAPTYQD VLYQAKQDKM TNAKNRTENS DRERDVYEEL LTQAEIQGNV
310 320 330 340 350
NKVNTSSALA NISLALEQGC AVTLLKALQS LALGLRGLQT QNSDWYMKQL
360 370 380 390 400
QSDLQQKRQS GQTDPLQKEE VQAGVDAANS AAQQYQRRLA AVAAINAAIQ
410 420 430 440 450
KGIAEKTVLE LMNPEAQLPQ VYPFAADLYQ KELATLQQQS PEHSLTHPEL
460 470 480 490 500
TVAVEMLSSV ALINRALESG DMTTVWKQLS SSVTGLTNIE EENCQRYLDE
510 520 530 540 550
LMKLKAQAHA ENNAFITWND IQACVDHVNL VVHEEHERIL AIGLINEALD
560 570 580 590 600
EGDAQKTLQA LQIPAAKLEG VLAEVAQHYQ DTLIRAKREK AQETQDESAV
610 620 630 640 650
LWLDEIQGGI WQSNKDTQEA QRFALGISAI NEAVDSGDVG RTLSALRSPD
660 670 680 690 700
VGLYGVIPEC GETYQSDLAE AKKKRLAAGD NNSKWVKHWV KGGYHYYHNL
710 720 730 740 750
ETQAGGWAEP PDFVQNSVQL SREEIQSSIS GVTAAYNREQ LWLANEGLIT
760 770 780 790 800
KLQACCRGYL VRQEFRSRMN FLKKQIPAIT CIQSQWRGYK QKKAYQDRLA
810 820 830 840 850
YLHSHKDEVV KIQSLARMHQ ARKRYRDRLQ YFRDHINDII KIQAFIRANK
860 870 880 890 900
ARDDYKTLIN AEDPPMIVVR KFVHLLDQSD QDFQEELDLM KMREEVITLI
910 920 930 940 950
RSNQQLENDL NLMDIKIGLL VKNKITLQDV VSHSKKLTKK NKEQLSDMMM
960 970 980 990 1000
INKQKGGLKA LSKEKREKLE AYQHLFYLLQ TNPTYLAKLI FQMPQNKSTK
1010 1020 1030 1040 1050
FMDSVIFTLY NYASNQREEY LLLRLFQTAL QEEIKSKVDQ IQEIVTGNPT
1060 1070 1080 1090 1100
VIKMVVSFNR GARGQNALRQ ILAPVVKEIM DDKSLNIKTD PVDIYKSWVN
1110 1120 1130 1140 1150
QMESQTGEAS KLPYDVTPEQ ALSHEEVKTR LDNSIRNMRA VTDKFLSAIV
1160 1170 1180 1190 1200
SSVDKIPYGM RFIAKVLKDS LHEKFPDAGE DELLKIIGNL LYYRYMNPAI
1210 1220 1230 1240 1250
VAPDAFDIID LSAGGQLTTD QRRNLGSIAK MLQHAASNKM FLGDNAHLSI
1260 1270 1280 1290 1300
INEYLSQSYQ KFRRFFQVAC DVPELQDKFN VDEYSDLVTL TKPVIYISIG
1310 1320 1330 1340 1350
EIINTHTLLL DHQDAIAPEH NDPIHELLDD LGEVPTIESL IGESCGNSND
1360 1370 1380 1390 1400
PNKEALAKTE VSLTLTNKFD VPGDENAEMD ARTILLNTKR LIVDVIRFQP
1410 1420 1430 1440 1450
GETLTEILET PATNEQEAEH QRAMQRRAIR DAKTPDKMKK SKPMKEDNNL
1460 1470 1480 1490 1500
SLQEKKEKIQ TGLKKLTELG TVDPKNRYQE LINDIAKDIR NQRRYRQRRK
1510 1520 1530 1540 1550
AELVKLQQTY SALNSKATFY GEQVDYYKSY IKTCLDNLAS KGKVSKKPRE
1560 1570 1580 1590 1600
MKGKKSKKIS LKYTAARLHE KGVLLEIEDL QANQFKNVIF EIGPTEEVGD
1610 1620 1630 1640 1650
FEVKAKFMGV QMETFMLHYQ DLLQLQYEGV AVMKLFDRAK VNVNLLIFLL

NKKFYGK
Length:1,657
Mass (Da):188,742
Last modified:October 3, 2012 - v2
Checksum:i9136695557ADA784
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1268V → L in AAF60344 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240630 mRNA Translation: AAF60344.1
AC109257 Genomic DNA No translation available.
AC127594 Genomic DNA No translation available.
CH466543 Genomic DNA Translation: EDL06977.1
CCDSiCCDS40001.1
RefSeqiNP_057930.2, NM_016721.2
UniGeneiMm.207619

Genome annotation databases

EnsembliENSMUST00000167377; ENSMUSP00000128278; ENSMUSG00000030536
GeneIDi29875
KEGGimmu:29875
UCSCiuc009ibc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIQGA1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKF1
Secondary accession number(s): G3UW45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: October 3, 2012
Last modified: July 18, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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