UniProtKB - Q9JKE2 (TREM1_MOUSE)
Triggering receptor expressed on myeloid cells 1
Trem1
Functioni
Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:23241959, PubMed:27328755).
By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- scaffold protein binding Source: MGI
- signaling receptor activity Source: InterPro
GO - Biological processi
- acute inflammatory response Source: InterPro
- adaptive immune response Source: UniProtKB-KW
- cell migration Source: MGI
- innate immune response Source: UniProtKB-KW
- neutrophil chemotaxis Source: MGI
- neutrophil extravasation Source: MGI
- neutrophil-mediated killing of gram-negative bacterium Source: MGI
- positive regulation of cardiac muscle cell apoptotic process Source: MGI
- positive regulation of cell-matrix adhesion Source: MGI
- positive regulation of macrophage chemotaxis Source: MGI
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity, Innate immunity |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-2172127, DAP12 interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Triggering receptor expressed on myeloid cells 1Short name: TREM-1 Alternative name(s): CD_antigen: CD354 |
Gene namesi | Name:Trem1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1930005, Trem1 |
VEuPathDBi | HostDB:ENSMUSG00000042265 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Note: Recruited to lipid rafts when activated.By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 202 | ExtracellularSequence analysisAdd BLAST | 182 | |
Transmembranei | 203 – 223 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 224 – 230 | CytoplasmicSequence analysis | 7 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000042797 | 21 – 230 | Triggering receptor expressed on myeloid cells 1Add BLAST | 210 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 41 ↔ 113 | Combined sources1 Publication | ||
Glycosylationi | 191 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9JKE2 |
PRIDEi | Q9JKE2 |
TopDownProteomicsi | Q9JKE2 |
PTM databases
GlyGeni | Q9JKE2, 1 site |
iPTMneti | Q9JKE2 |
PhosphoSitePlusi | Q9JKE2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000042265, Expressed in granulocyte and 106 other tissues |
ExpressionAtlasi | Q9JKE2, baseline and differential |
Genevisiblei | Q9JKE2, MM |
Interactioni
Subunit structurei
Monomer (PubMed:15561137). Homomultimer; when activated.
Interacts with TYROBP/DAP12.
Interacts with TLR4 (By similarity).
By similarity1 PublicationGO - Molecular functioni
- scaffold protein binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000038636 |
Miscellaneous databases
RNActi | Q9JKE2, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9JKE2 |
SMRi | Q9JKE2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9JKE2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 124 | Ig-like V-typeAdd BLAST | 104 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502TE0T, Eukaryota |
GeneTreei | ENSGT00470000042299 |
HOGENOMi | CLU_1170307_0_0_1 |
InParanoidi | Q9JKE2 |
OMAi | NIMKYAN |
OrthoDBi | 1472586at2759 |
PhylomeDBi | Q9JKE2 |
TreeFami | TF339293 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR039141, TREM1 |
PANTHERi | PTHR19357:SF0, PTHR19357:SF0, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MRKAGLWGLL CVFFVSEVKA AIVLEEERYD LVEGQTLTVK CPFNIMKYAN
60 70 80 90 100
SQKAWQRLPD GKEPLTLVVT QRPFTRPSEV HMGKFTLKHD PSEAMLQVQM
110 120 130 140 150
TDLQVTDSGL YRCVIYHPPN DPVVLFHPVR LVVTKGSSDV FTPVIIPITR
160 170 180 190 200
LTERPILITT KYSPSDTTTT RSLPKPTAVV SSPGLGVTII NGTDADSVST
210 220 230
SSVTISVICG LLSKSLVFII LFIVTKRTFG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ14DT9 | Q14DT9_MOUSE | Trem1 protein | Trem1 | 111 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 92 | S → T in BAE42651 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF241219 mRNA Translation: AAF69834.1 AK089439 mRNA Translation: BAC40884.1 AK171753 mRNA Translation: BAE42651.1 |
CCDSi | CCDS28860.1 |
RefSeqi | NP_067381.1, NM_021406.5 |
Genome annotation databases
Ensembli | ENSMUST00000048782; ENSMUSP00000038636; ENSMUSG00000042265 |
GeneIDi | 58217 |
KEGGi | mmu:58217 |
UCSCi | uc029tij.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF241219 mRNA Translation: AAF69834.1 AK089439 mRNA Translation: BAC40884.1 AK171753 mRNA Translation: BAE42651.1 |
CCDSi | CCDS28860.1 |
RefSeqi | NP_067381.1, NM_021406.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1U9K | X-ray | 1.76 | A/B | 21-134 | [»] | |
AlphaFoldDBi | Q9JKE2 | |||||
SMRi | Q9JKE2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000038636 |
PTM databases
GlyGeni | Q9JKE2, 1 site |
iPTMneti | Q9JKE2 |
PhosphoSitePlusi | Q9JKE2 |
Proteomic databases
PaxDbi | Q9JKE2 |
PRIDEi | Q9JKE2 |
TopDownProteomicsi | Q9JKE2 |
Protocols and materials databases
ABCDi | Q9JKE2, 21 sequenced antibodies |
Antibodypediai | 1616, 760 antibodies from 40 providers |
DNASUi | 58217 |
Genome annotation databases
Ensembli | ENSMUST00000048782; ENSMUSP00000038636; ENSMUSG00000042265 |
GeneIDi | 58217 |
KEGGi | mmu:58217 |
UCSCi | uc029tij.2, mouse |
Organism-specific databases
CTDi | 54210 |
MGIi | MGI:1930005, Trem1 |
VEuPathDBi | HostDB:ENSMUSG00000042265 |
Phylogenomic databases
eggNOGi | ENOG502TE0T, Eukaryota |
GeneTreei | ENSGT00470000042299 |
HOGENOMi | CLU_1170307_0_0_1 |
InParanoidi | Q9JKE2 |
OMAi | NIMKYAN |
OrthoDBi | 1472586at2759 |
PhylomeDBi | Q9JKE2 |
TreeFami | TF339293 |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-2172127, DAP12 interactions |
Miscellaneous databases
BioGRID-ORCSi | 58217, 1 hit in 74 CRISPR screens |
EvolutionaryTracei | Q9JKE2 |
PROi | PR:Q9JKE2 |
RNActi | Q9JKE2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000042265, Expressed in granulocyte and 106 other tissues |
ExpressionAtlasi | Q9JKE2, baseline and differential |
Genevisiblei | Q9JKE2, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR039141, TREM1 |
PANTHERi | PTHR19357:SF0, PTHR19357:SF0, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TREM1_MOUSE | |
Accessioni | Q9JKE2Primary (citable) accession number: Q9JKE2 Secondary accession number(s): Q3TAL7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references