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Protein

Secretory carrier-associated membrane protein 5

Gene

Scamp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory carrier-associated membrane protein 5
Short name:
Secretory carrier membrane protein 5
Gene namesi
Name:Scamp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1928948 Scamp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 67ExtracellularSequence analysis7
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 102CytoplasmicSequence analysisAdd BLAST14
Transmembranei103 – 125HelicalSequence analysisAdd BLAST23
Topological domaini126 – 148ExtracellularSequence analysisAdd BLAST23
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 235CytoplasmicSequence analysisAdd BLAST66

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912631 – 235Secretory carrier-associated membrane protein 5Add BLAST235

Proteomic databases

MaxQBiQ9JKD3
PaxDbiQ9JKD3
PeptideAtlasiQ9JKD3
PRIDEiQ9JKD3

PTM databases

iPTMnetiQ9JKD3
PhosphoSitePlusiQ9JKD3
SwissPalmiQ9JKD3

Expressioni

Tissue specificityi

Brain-specific.1 Publication

Developmental stagei

Expressed late in development coincident with the elaboration of mature synapses.

Gene expression databases

BgeeiENSMUSG00000040722 Expressed in 224 organ(s), highest expression level in hypothalamus
CleanExiMM_SCAMP5
ExpressionAtlasiQ9JKD3 baseline and differential
GenevisibleiQ9JKD3 MM

Interactioni

Subunit structurei

Interacts (via C-terminal part) with SYT1 and SYT2; interaction with synaptotagmins making a link with the SNARE molecules. Interacts with SLC9A7 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035898

Family & Domainsi

Sequence similaritiesi

Belongs to the SCAMP family. SCAMP5 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3088 Eukaryota
ENOG410XSJN LUCA
GeneTreeiENSGT00390000014393
HOGENOMiHOG000294221
HOVERGENiHBG071938
InParanoidiQ9JKD3
KOiK19995
OMAiSGWIATI
OrthoDBiEOG091G0ID2
PhylomeDBiQ9JKD3
TreeFamiTF313797

Family and domain databases

InterProiView protein in InterPro
IPR007273 SCAMP
PANTHERiPTHR10687 PTHR10687, 1 hit
PfamiView protein in Pfam
PF04144 SCAMP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9JKD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEKVNNFPP LPKFIPLKPC FYQDFEADIP PQHLSLTKRL YYLWMLNSVT
60 70 80 90 100
LAVNLVGCLA WLIGGGGATN FGLAFLWLIL FTPCSYVCWF RPIYKAFKTD
110 120 130 140 150
SSFSFMAFFF TFMAQLVISI IQAVGIPGWG VCGWIATISF FGTNIGSAVV
160 170 180 190 200
MLIPTVMFTV VAVFSFIALS MVHKFYRGSG GSFSKAQEEW TTGAWKNPHV
210 220 230
QQAAQNAAMG AAQGAMNQPQ TQYSATPNYT YSNEM
Length:235
Mass (Da):26,068
Last modified:October 1, 2000 - v1
Checksum:i5C2C25568FB1399F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SRT6A0A1L1SRT6_MOUSE
Secretory carrier-associated membra...
Scamp5
69Annotation score:
A0A1L1SVG3A0A1L1SVG3_MOUSE
Secretory carrier-associated membra...
Scamp5
45Annotation score:
A0A1L1STB8A0A1L1STB8_MOUSE
Secretory carrier-associated membra...
Scamp5
44Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241833 mRNA Translation: AAF64491.1
BC018613 mRNA Translation: AAH18613.1
CCDSiCCDS40649.1
RefSeqiNP_001288563.1, NM_001301634.1
NP_001288564.1, NM_001301635.1
NP_064666.1, NM_020270.3
XP_006511383.1, XM_006511320.3
XP_017168984.1, XM_017313495.1
UniGeneiMm.102278

Genome annotation databases

EnsembliENSMUST00000046587; ENSMUSP00000035898; ENSMUSG00000040722
ENSMUST00000214256; ENSMUSP00000150867; ENSMUSG00000040722
GeneIDi56807
KEGGimmu:56807
UCSCiuc009puw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241833 mRNA Translation: AAF64491.1
BC018613 mRNA Translation: AAH18613.1
CCDSiCCDS40649.1
RefSeqiNP_001288563.1, NM_001301634.1
NP_001288564.1, NM_001301635.1
NP_064666.1, NM_020270.3
XP_006511383.1, XM_006511320.3
XP_017168984.1, XM_017313495.1
UniGeneiMm.102278

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035898

PTM databases

iPTMnetiQ9JKD3
PhosphoSitePlusiQ9JKD3
SwissPalmiQ9JKD3

Proteomic databases

MaxQBiQ9JKD3
PaxDbiQ9JKD3
PeptideAtlasiQ9JKD3
PRIDEiQ9JKD3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046587; ENSMUSP00000035898; ENSMUSG00000040722
ENSMUST00000214256; ENSMUSP00000150867; ENSMUSG00000040722
GeneIDi56807
KEGGimmu:56807
UCSCiuc009puw.2 mouse

Organism-specific databases

CTDi192683
MGIiMGI:1928948 Scamp5

Phylogenomic databases

eggNOGiKOG3088 Eukaryota
ENOG410XSJN LUCA
GeneTreeiENSGT00390000014393
HOGENOMiHOG000294221
HOVERGENiHBG071938
InParanoidiQ9JKD3
KOiK19995
OMAiSGWIATI
OrthoDBiEOG091G0ID2
PhylomeDBiQ9JKD3
TreeFamiTF313797

Miscellaneous databases

ChiTaRSiScamp5 mouse
PROiPR:Q9JKD3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040722 Expressed in 224 organ(s), highest expression level in hypothalamus
CleanExiMM_SCAMP5
ExpressionAtlasiQ9JKD3 baseline and differential
GenevisibleiQ9JKD3 MM

Family and domain databases

InterProiView protein in InterPro
IPR007273 SCAMP
PANTHERiPTHR10687 PTHR10687, 1 hit
PfamiView protein in Pfam
PF04144 SCAMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCAM5_MOUSE
AccessioniPrimary (citable) accession number: Q9JKD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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