Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

AP-3 complex subunit mu-1

Gene

Ap3m1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.1 Publication

GO - Molecular functioni

GO - Biological processi

  • anterograde axonal transport Source: UniProtKB
  • anterograde synaptic vesicle transport Source: UniProtKB
  • intracellular protein transport Source: InterPro

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit mu-1
Alternative name(s):
AP-3 adaptor complex mu3A subunit
Adaptor-related protein complex 3 subunit mu-1
Mu-adaptin 3A
Mu3A-adaptin
Gene namesi
Name:Ap3m1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1929212 Ap3m1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937821 – 418AP-3 complex subunit mu-1Add BLAST418

Proteomic databases

EPDiQ9JKC8
MaxQBiQ9JKC8
PaxDbiQ9JKC8
PeptideAtlasiQ9JKC8
PRIDEiQ9JKC8

PTM databases

iPTMnetiQ9JKC8
PhosphoSitePlusiQ9JKC8

Expressioni

Gene expression databases

BgeeiENSMUSG00000021824 Expressed in 277 organ(s), highest expression level in secondary oocyte
CleanExiMM_AP3M1
ExpressionAtlasiQ9JKC8 baseline and differential
GenevisibleiQ9JKC8 MM

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ9JKC8
IntActiQ9JKC8, 1 interactor
MINTiQ9JKC8
STRINGi10090.ENSMUSP00000117346

Structurei

3D structure databases

ProteinModelPortaliQ9JKC8
SMRiQ9JKC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 417MHDPROSITE-ProRule annotationAdd BLAST242

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2740 Eukaryota
ENOG410XT7B LUCA
GeneTreeiENSGT00530000062779
HOGENOMiHOG000234366
HOVERGENiHBG104910
InParanoidiQ9JKC8
KOiK12398
OMAiHMPKAVL
OrthoDBiEOG091G088V
TreeFamiTF315187

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR001392 Clathrin_mu
IPR018240 Clathrin_mu_CS
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992 Clathrin_mu, 1 hit
PRINTSiPR00314 CLATHRINADPT
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9JKC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIHSLFLINC SGDIFLEKHW KSVVSQSVCD YFFEAQEKAA DVENVPPVIS
60 70 80 90 100
TPHHYLISIY RDKLFFVSVI QTEVPPLFVI EFLHRVADTF QDYFGECSEA
110 120 130 140 150
AIKDNVVIVY ELLEEMLDNG FPLATESNIL KELIKPPTIL RSVVNSITGS
160 170 180 190 200
SNVGDTLPTG QLSNIPWRRA GVKYTNNEAY FDVVEEIDAI IDKSGSTVFA
210 220 230 240 250
EIQGVIDACI KLSGMPDLSL SFMNPRLLDD VSFHPCIRFK RWESERVLSF
260 270 280 290 300
IPPDGNFRLI SYRVSSQNLV AIPVYVKHSI SFKENSSCGR FDITIGPKQN
310 320 330 340 350
MGKTIEGITV TVHMPKVVLN MNLTPTQGSY TFDPVTKVLA WDVGKITPQK
360 370 380 390 400
LPSLKGLVNL QSGAPKPEEN PNLNIQFKIQ QLAISGLKVN RLDMYGEKYK
410
PFKGVKYVTK AGKFQVRT
Length:418
Mass (Da):46,936
Last modified:October 1, 2000 - v1
Checksum:i69EC322D820C47D3
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BWY2H7BWY2_MOUSE
AP-3 complex subunit mu-1
Ap3m1
364Annotation score:
A0A286YDZ6A0A286YDZ6_MOUSE
AP-3 complex subunit mu-1
Ap3m1 mCG_16390
204Annotation score:
D3YXV9D3YXV9_MOUSE
AP-3 complex subunit mu-1
Ap3m1
174Annotation score:
D3YWU3D3YWU3_MOUSE
AP-3 complex subunit mu-1
Ap3m1
148Annotation score:
D6RI63D6RI63_MOUSE
AP-3 complex subunit mu-1
Ap3m1
114Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242857 mRNA Translation: AAF63512.1
BC024595 mRNA Translation: AAH24595.1
BC090983 mRNA Translation: AAH90983.1
CCDSiCCDS26861.1
RefSeqiNP_061299.3, NM_018829.4
XP_006519355.1, XM_006519292.1
XP_006519356.1, XM_006519293.1
UniGeneiMm.376269

Genome annotation databases

EnsembliENSMUST00000154460; ENSMUSP00000117346; ENSMUSG00000021824
GeneIDi55946
KEGGimmu:55946
UCSCiuc007sla.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242857 mRNA Translation: AAF63512.1
BC024595 mRNA Translation: AAH24595.1
BC090983 mRNA Translation: AAH90983.1
CCDSiCCDS26861.1
RefSeqiNP_061299.3, NM_018829.4
XP_006519355.1, XM_006519292.1
XP_006519356.1, XM_006519293.1
UniGeneiMm.376269

3D structure databases

ProteinModelPortaliQ9JKC8
SMRiQ9JKC8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ9JKC8
IntActiQ9JKC8, 1 interactor
MINTiQ9JKC8
STRINGi10090.ENSMUSP00000117346

PTM databases

iPTMnetiQ9JKC8
PhosphoSitePlusiQ9JKC8

Proteomic databases

EPDiQ9JKC8
MaxQBiQ9JKC8
PaxDbiQ9JKC8
PeptideAtlasiQ9JKC8
PRIDEiQ9JKC8

Protocols and materials databases

DNASUi55946
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000154460; ENSMUSP00000117346; ENSMUSG00000021824
GeneIDi55946
KEGGimmu:55946
UCSCiuc007sla.2 mouse

Organism-specific databases

CTDi26985
MGIiMGI:1929212 Ap3m1

Phylogenomic databases

eggNOGiKOG2740 Eukaryota
ENOG410XT7B LUCA
GeneTreeiENSGT00530000062779
HOGENOMiHOG000234366
HOVERGENiHBG104910
InParanoidiQ9JKC8
KOiK12398
OMAiHMPKAVL
OrthoDBiEOG091G088V
TreeFamiTF315187

Miscellaneous databases

ChiTaRSiAp3m1 mouse
PROiPR:Q9JKC8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021824 Expressed in 277 organ(s), highest expression level in secondary oocyte
CleanExiMM_AP3M1
ExpressionAtlasiQ9JKC8 baseline and differential
GenevisibleiQ9JKC8 MM

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR001392 Clathrin_mu
IPR018240 Clathrin_mu_CS
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992 Clathrin_mu, 1 hit
PRINTSiPR00314 CLATHRINADPT
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAP3M1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKC8
Secondary accession number(s): Q5BKQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again