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Protein

C-C motif chemokine 24

Gene

Ccl24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Binds to CCR3 (By similarity).By similarity

GO - Molecular functioni

  • CCR3 chemokine receptor binding Source: MGI
  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: MGI
  • cytokine activity Source: MGI
  • receptor ligand activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 24
Alternative name(s):
Eosinophil chemotactic protein 2
Eotaxin-2
Small-inducible cytokine A24
Gene namesi
Name:Ccl24
Synonyms:Scya24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1928953 Ccl24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000523327 – 119C-C motif chemokine 24Add BLAST93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 58By similarity
Disulfide bondi34 ↔ 74By similarity
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9JKC0
PaxDbiQ9JKC0
PRIDEiQ9JKC0

Expressioni

Tissue specificityi

Highest expression in jejunum and spleen. Lower levels found in liver and lung. No expression detected in kidney, thymus, brain or testis.1 Publication

Inductioni

By interleukin-4 and allergen challenge with A.fumigatus.1 Publication

Gene expression databases

BgeeiENSMUSG00000004814 Expressed in 43 organ(s), highest expression level in intestine
CleanExiMM_CCL24
ExpressionAtlasiQ9JKC0 baseline and differential
GenevisibleiQ9JKC0 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004936

Structurei

3D structure databases

ProteinModelPortaliQ9JKC0
SMRiQ9JKC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCGF Eukaryota
ENOG41119KC LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ9JKC0
KOiK21097
OMAiGQKFCGD
OrthoDBiEOG091G1251
PhylomeDBiQ9JKC0
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGSATIVAG LLLLVACACC IFPIDSVTIP SSCCTSFISK KIPENRVVSY
60 70 80 90 100
QLANGSICPK AGVIFITKKG HKICTDPKLL WVQRHIQKLD AKKNQPSKGA
110
KAVRTKFAVQ RRRGNSTEV
Length:119
Mass (Da):12,871
Last modified:October 1, 2000 - v1
Checksum:i1EA921B3F13138A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244367 mRNA Translation: AAF61736.1
AF281075 mRNA Translation: AAG32664.1
BC065389 mRNA Translation: AAH65389.1
CCDSiCCDS19742.1
RefSeqiNP_062523.1, NM_019577.4
XP_006504507.1, XM_006504444.3
XP_006504508.1, XM_006504445.3
UniGeneiMm.31505

Genome annotation databases

EnsembliENSMUST00000004936; ENSMUSP00000004936; ENSMUSG00000004814
ENSMUST00000201401; ENSMUSP00000144002; ENSMUSG00000004814
GeneIDi56221
KEGGimmu:56221
UCSCiuc008zyn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244367 mRNA Translation: AAF61736.1
AF281075 mRNA Translation: AAG32664.1
BC065389 mRNA Translation: AAH65389.1
CCDSiCCDS19742.1
RefSeqiNP_062523.1, NM_019577.4
XP_006504507.1, XM_006504444.3
XP_006504508.1, XM_006504445.3
UniGeneiMm.31505

3D structure databases

ProteinModelPortaliQ9JKC0
SMRiQ9JKC0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004936

Proteomic databases

MaxQBiQ9JKC0
PaxDbiQ9JKC0
PRIDEiQ9JKC0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004936; ENSMUSP00000004936; ENSMUSG00000004814
ENSMUST00000201401; ENSMUSP00000144002; ENSMUSG00000004814
GeneIDi56221
KEGGimmu:56221
UCSCiuc008zyn.1 mouse

Organism-specific databases

CTDi6369
MGIiMGI:1928953 Ccl24

Phylogenomic databases

eggNOGiENOG410JCGF Eukaryota
ENOG41119KC LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ9JKC0
KOiK21097
OMAiGQKFCGD
OrthoDBiEOG091G1251
PhylomeDBiQ9JKC0
TreeFamiTF334888

Miscellaneous databases

PROiPR:Q9JKC0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004814 Expressed in 43 organ(s), highest expression level in intestine
CleanExiMM_CCL24
ExpressionAtlasiQ9JKC0 baseline and differential
GenevisibleiQ9JKC0 MM

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL24_MOUSE
AccessioniPrimary (citable) accession number: Q9JKC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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