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Protein

Cell surface A33 antigen

Gene

Gpa33

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in cell-cell recognition and signaling.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface A33 antigen
Alternative name(s):
Glycoprotein A33
Short name:
mA33
Gene namesi
Name:Gpa33
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1891703 Gpa33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 235ExtracellularSequence analysisAdd BLAST214
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 319CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001477122 – 319Cell surface A33 antigenAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 117PROSITE-ProRule annotation
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 222PROSITE-ProRule annotation
Disulfide bondi162 ↔ 211PROSITE-ProRule annotation
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ9JKA5
PaxDbiQ9JKA5
PeptideAtlasiQ9JKA5
PRIDEiQ9JKA5

PTM databases

PhosphoSitePlusiQ9JKA5

Expressioni

Gene expression databases

CleanExiMM_GPA33

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060147

Structurei

3D structure databases

ProteinModelPortaliQ9JKA5
SMRiQ9JKA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 134Ig-like V-typeAdd BLAST113
Domaini140 – 227Ig-like C2-typeAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 261Poly-Cys4

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWKU Eukaryota
ENOG410YJEV LUCA
HOGENOMiHOG000112779
HOVERGENiHBG051792
InParanoidiQ9JKA5
KOiK06790
PhylomeDBiQ9JKA5
TreeFamiTF330875

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JKA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGKAGSVVW MLCAIWVAAD ALTVETTQDI LRAARGRSVT LPCTYNTYVS
60 70 80 90 100
DREGFIQWDK LLRSQTERVV TWNFVTKKYI YGNRYENRVR VSNDAELSNA
110 120 130 140 150
SITIDQLTMD DNGTYECSVS LMSDQDVNAK SRVRLLVLVP PSKPDCSIQG
160 170 180 190 200
EMVIGNNIQL TCHSAEGSPS PQYSWKSYNA QNQQRPLTQP VSGEPLLLKN
210 220 230 240 250
ISTETAGYYI CTSSNDVGIE SCNITVAPRP PSMNIALYAG IAGGVFVALI
260 270 280 290 300
IIGVIVYCCC CREKDDKDQD REDARPNRAA YQVPKKEQKE ISRGREDEDD
310
HRHEDRWSSG RSTPDQPFQ
Length:319
Mass (Da):35,692
Last modified:April 26, 2004 - v2
Checksum:iA37C8DB4BF685C3A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J209A0A0R4J209_MOUSE
Cell surface A33 antigen
Gpa33 mCG_3599
319Annotation score:
E9PY15E9PY15_MOUSE
Cell surface A33 antigen
Gpa33
36Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → F in AAF65818 (PubMed:10960348).Curated1
Sequence conflicti244G → S in AAF65818 (PubMed:10960348).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247659 mRNA Translation: AAF65818.1
BC008528 mRNA Translation: AAH08528.1
CCDSiCCDS15447.1
RefSeqiNP_067623.1, NM_021610.1
UniGeneiMm.46357

Genome annotation databases

GeneIDi59290
KEGGimmu:59290
UCSCiuc007dkj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247659 mRNA Translation: AAF65818.1
BC008528 mRNA Translation: AAH08528.1
CCDSiCCDS15447.1
RefSeqiNP_067623.1, NM_021610.1
UniGeneiMm.46357

3D structure databases

ProteinModelPortaliQ9JKA5
SMRiQ9JKA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060147

PTM databases

PhosphoSitePlusiQ9JKA5

Proteomic databases

MaxQBiQ9JKA5
PaxDbiQ9JKA5
PeptideAtlasiQ9JKA5
PRIDEiQ9JKA5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi59290
KEGGimmu:59290
UCSCiuc007dkj.1 mouse

Organism-specific databases

CTDi10223
MGIiMGI:1891703 Gpa33

Phylogenomic databases

eggNOGiENOG410IWKU Eukaryota
ENOG410YJEV LUCA
HOGENOMiHOG000112779
HOVERGENiHBG051792
InParanoidiQ9JKA5
KOiK06790
PhylomeDBiQ9JKA5
TreeFamiTF330875

Miscellaneous databases

PROiPR:Q9JKA5
SOURCEiSearch...

Gene expression databases

CleanExiMM_GPA33

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGPA33_MOUSE
AccessioniPrimary (citable) accession number: Q9JKA5
Secondary accession number(s): Q922D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: February 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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