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Protein

Potassium voltage-gated channel subfamily KQT member 4

Gene

Kcnq4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea.

GO - Molecular functioni

  • potassium channel activity Source: MGI
  • voltage-gated potassium channel activity Source: MGI

GO - Biological processi

  • inner ear morphogenesis Source: MGI
  • negative regulation of synaptic transmission, dopaminergic Source: MGI
  • potassium ion transport Source: MGI
  • regulation of ion transmembrane transport Source: UniProtKB-KW
  • sensory perception of sound Source: MGI

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processHearing, Ion transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily KQT member 4
Alternative name(s):
KQT-like 4
Potassium channel subunit alpha KvLQT4
Voltage-gated potassium channel subunit Kv7.4
Gene namesi
Name:Kcnq4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1926803 Kcnq4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 97CytoplasmicSequence analysisAdd BLAST97
Transmembranei98 – 118Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini119 – 131ExtracellularSequence analysisAdd BLAST13
Transmembranei132 – 152Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini153 – 172CytoplasmicSequence analysisAdd BLAST20
Transmembranei173 – 193Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini194 – 201ExtracellularSequence analysis8
Transmembranei202 – 224Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST23
Topological domaini225 – 237CytoplasmicSequence analysisAdd BLAST13
Transmembranei238 – 258Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini259 – 270ExtracellularSequence analysisAdd BLAST12
Intramembranei271 – 292Pore-forming; Name=Segment H5Sequence analysisAdd BLAST22
Topological domaini293 – 296ExtracellularSequence analysis4
Transmembranei297 – 317Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini318 – 695CytoplasmicSequence analysisAdd BLAST378

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540381 – 696Potassium voltage-gated channel subfamily KQT member 4Add BLAST696

Proteomic databases

PaxDbiQ9JK97
PRIDEiQ9JK97

PTM databases

iPTMnetiQ9JK97
PhosphoSitePlusiQ9JK97

Expressioni

Tissue specificityi

In the inner ear expressed in the outer sensory hair cells of the cochlea and in type I hair cells of the vestibular organs. Also expressed in the postsynaptic membrane of the calyx nerve endings innervating type I cells. In the brain expressed in neurons of many, but not all, nuclei of the central auditory pathway. Absent from most other brain regions.1 Publication

Gene expression databases

BgeeiENSMUSG00000028631
GenevisibleiQ9JK97 MM

Interactioni

Subunit structurei

Homotetramer. May form heteromultimers with KCNQ3 (By similarity). Interacts with HSP90AB1; promotes cell surface expression of KCNQ4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030376

Structurei

3D structure databases

ProteinModelPortaliQ9JK97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni546 – 650A-domain (Tetramerization)By similarityAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili610 – 645Add BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi284 – 289Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity
The A-domain tail carries the major determinants of channel assembly specificity. Its coiled-coil region is Four-stranded (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1419 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00550000074513
HOGENOMiHOG000220839
HOVERGENiHBG059014
InParanoidiQ9JK97
KOiK04929
OMAiWAFVYHV
OrthoDBiEOG091G02ZT
PhylomeDBiQ9JK97
TreeFamiTF315186

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR003937 K_chnl_volt-dep_KCNQ
IPR013821 K_chnl_volt-dep_KCNQ_C
IPR015573 KCQN4
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF4 PTHR11537:SF4, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF03520 KCNQ_channel, 1 hit
PRINTSiPR00169 KCHANNEL
PR01459 KCNQCHANNEL

Sequencei

Sequence statusi: Complete.

Q9JK97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAPPRRLG LGPPPGDAPR AELVALTAVQ SEQGEAGGGG SPRRLGLLGS
60 70 80 90 100
PLPPGAPLPG PGSGSGSACG GQRSSAAQKR YRRLQNWVYN VLERPRGWAF
110 120 130 140 150
VYHVFIFLLV FSCLVLSVLS TIQEHQELAN ECLLILEFVM IVVFGLEYII
160 170 180 190 200
RVWSAGCCCR YRGWQGRFRF ARKPFCVIDF IVFVASVAVI AAGTQGNIFA
210 220 230 240 250
TSALRSMRFL QILRMVRMDR RGGTWKLLGS VVYAHSKELI TAWYIGFLVL
260 270 280 290 300
IFASFLVYLA EKDANSDFSS YADSLWWGTI TLTTIGYGDK TPHTWLGRVL
310 320 330 340 350
AAGFALLGIS FFALPAGILG SGFALKVQEQ HRQKHFEKRR MPAANLIQAA
360 370 380 390 400
WRLYSTDTSR AYLTATWYYY DSILPSFREL ALLFEHIQRA RNGGLRPLEV
410 420 430 440 450
RRAPVPDGAP SRYPPVATCH RPGSASFCPG ESSRMGIKDR IRISSSQKRT
460 470 480 490 500
GPSKQHLAPP PIPTSPSSEQ VGEASSPSKV QKSWSFNDRT RFRASLRLKP
510 520 530 540 550
RCSAEEGPSE EVAEEKSYQC ELTVDDVMPA VKTVIRSVRI LKFLVAKRKF
560 570 580 590 600
KETLRPYDVK DVIEQYSAGH LDMLGRIKSL QARVDQIVGR GPGDRKTREK
610 620 630 640 650
GDKGPSDTEA VDEISMMGRV VKVEKQVQSI EHKLDLLLGF YSRCLRSGTS
660 670 680 690
ASLGTVQVPL FDPDITSDYH SPVDHEDISV SAQTLSISRS VSTNMD
Length:696
Mass (Da):77,057
Last modified:January 9, 2007 - v2
Checksum:i762B19DA32043E95
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti445S → I in AAF66432 (PubMed:11042367).Curated1
Sequence conflicti502C → S in AAF66432 (PubMed:11042367).Curated1
Sequence conflicti533T → S in BAC30534 (PubMed:16141072).Curated1
Sequence conflicti608T → A in AAF66432 (PubMed:11042367).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606924 Genomic DNA No translation available.
AK040190 mRNA Translation: BAC30534.1
AF249747 mRNA Translation: AAF66432.1
CCDSiCCDS38865.1
RefSeqiNP_001074611.1, NM_001081142.1
UniGeneiMm.249977

Genome annotation databases

EnsembliENSMUST00000030376; ENSMUSP00000030376; ENSMUSG00000028631
GeneIDi60613
KEGGimmu:60613
UCSCiuc008unm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKCNQ4_MOUSE
AccessioniPrimary (citable) accession number: Q9JK97
Secondary accession number(s): A2A7E8, Q8C9Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 9, 2007
Last modified: June 20, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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