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Protein

p53 apoptosis effector related to PMP-22

Gene

Perp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway.2 Publications

GO - Biological processi

Keywordsi

Biological processApoptosis, Cell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
p53 apoptosis effector related to PMP-22
Alternative name(s):
Keratinocyte-associated protein 1
Short name:
KCP-1
Gene namesi
Name:Perp
Synonyms:Krtcap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1929938 Perp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002269951 – 193p53 apoptosis effector related to PMP-22Add BLAST193

Proteomic databases

PaxDbiQ9JK95
PRIDEiQ9JK95

Expressioni

Tissue specificityi

Expressed in the stratified squamous skin epithelium of the skin and the tongue, but not in simple epithelia (at protein level). Expressed in apoptotic cells.2 Publications

Developmental stagei

Expressed in developing skin during and after the stratification process from 9.5 to 15.5 dpc (at protein level). Expressed in ectoderm of the developing branchial arches and limb buds from the 9.5 to 10.5 dpc. Expressed in epithelia of the oral mucosa and skin from the 16.5 to 18.5 dpc.1 Publication

Inductioni

Up-regulated by UV irradiation, doxorubicin (DOX) and TP53 in embryo fibroblasts.1 Publication

Gene expression databases

BgeeiENSMUSG00000019851 Expressed in 272 organ(s), highest expression level in skin epidermis
CleanExiMM_PERP
GenevisibleiQ9JK95 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019998

Structurei

3D structure databases

ProteinModelPortaliQ9JK95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM47 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4671 Eukaryota
ENOG4111P5K LUCA
GeneTreeiENSGT00530000063484
HOGENOMiHOG000057292
HOVERGENiHBG061500
InParanoidiQ9JK95
KOiK10136
OMAiTWAYGFG
OrthoDBiEOG091G0S9P
PhylomeDBiQ9JK95
TreeFamiTF312855

Family and domain databases

InterProiView protein in InterPro
IPR015664 P53_induced
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR14399 PTHR14399, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JK95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRCGLACER CRWILPLLLL SAIAFDIIAL AGRGWLQSSN HIQTSSLWWR
60 70 80 90 100
CFDEGGGSGS YDDGCQSLME YAWGRAAAAT LFCGFIILCI CFILSFFALC
110 120 130 140 150
GPQMLVFLRV IGGLLALAAI FQIISLVIYP VKYTQTFRLH DNPAVNYIYN
160 170 180 190
WAYGFGWAAT IILIGCSFFF CCLPNYEDDL LGAAKPRYFY PPA
Length:193
Mass (Da):21,567
Last modified:October 1, 2000 - v1
Checksum:iB1DD8A2AAC27A0AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249870 mRNA Translation: AAF64306.1
AF251009 Genomic DNA Translation: AAF70261.1
AK003734 mRNA Translation: BAB22968.1
AK009184 mRNA Translation: BAB26126.1
AK009190 mRNA Translation: BAB26130.1
BC021772 mRNA Translation: AAH21772.1
CCDSiCCDS23714.1
RefSeqiNP_071315.1, NM_022032.4
UniGeneiMm.28209

Genome annotation databases

EnsembliENSMUST00000019998; ENSMUSP00000019998; ENSMUSG00000019851
GeneIDi64058
KEGGimmu:64058
UCSCiuc007emz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249870 mRNA Translation: AAF64306.1
AF251009 Genomic DNA Translation: AAF70261.1
AK003734 mRNA Translation: BAB22968.1
AK009184 mRNA Translation: BAB26126.1
AK009190 mRNA Translation: BAB26130.1
BC021772 mRNA Translation: AAH21772.1
CCDSiCCDS23714.1
RefSeqiNP_071315.1, NM_022032.4
UniGeneiMm.28209

3D structure databases

ProteinModelPortaliQ9JK95
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019998

Proteomic databases

PaxDbiQ9JK95
PRIDEiQ9JK95

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019998; ENSMUSP00000019998; ENSMUSG00000019851
GeneIDi64058
KEGGimmu:64058
UCSCiuc007emz.1 mouse

Organism-specific databases

CTDi64065
MGIiMGI:1929938 Perp

Phylogenomic databases

eggNOGiKOG4671 Eukaryota
ENOG4111P5K LUCA
GeneTreeiENSGT00530000063484
HOGENOMiHOG000057292
HOVERGENiHBG061500
InParanoidiQ9JK95
KOiK10136
OMAiTWAYGFG
OrthoDBiEOG091G0S9P
PhylomeDBiQ9JK95
TreeFamiTF312855

Enzyme and pathway databases

ReactomeiR-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiPerp mouse
PROiPR:Q9JK95
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019851 Expressed in 272 organ(s), highest expression level in skin epidermis
CleanExiMM_PERP
GenevisibleiQ9JK95 MM

Family and domain databases

InterProiView protein in InterPro
IPR015664 P53_induced
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR14399 PTHR14399, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPERP_MOUSE
AccessioniPrimary (citable) accession number: Q9JK95
Secondary accession number(s): Q9JI77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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