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Protein

Heat shock protein beta-8

Gene

Hspb8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays temperature-dependent chaperone activity.

GO - Molecular functioni

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

ReactomeiR-MMU-3371571 HSF1-dependent transactivation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-8
Short name:
HspB8
Alternative name(s):
Alpha-crystallin C chain
Small stress protein-like protein HSP22
Gene namesi
Name:Hspb8
Synonyms:Cryac, Hsp22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2135756 Hspb8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259471 – 196Heat shock protein beta-8Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei63PhosphothreonineBy similarity1
Modified residuei71Asymmetric dimethylarginineCombined sources1
Modified residuei78Asymmetric dimethylarginineCombined sources1
Modified residuei87PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9JK92
PaxDbiQ9JK92
PeptideAtlasiQ9JK92
PRIDEiQ9JK92

PTM databases

iPTMnetiQ9JK92
PhosphoSitePlusiQ9JK92

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle, heart, uterus, liver, lung and ovary. Low levels found in stomach and brain. Not detected in small intestine, large intestine, kidney, spleen and testis. In the ovary, expression is concentrated in the endometrium and in the connective tissue between the circular and longitudinal muscles of the myometrium.1 Publication

Developmental stagei

Detected in developing heart throughout embryonic development but only detected in developing liver close to time of birth. In the adult ovary, expression is highest during decidualization and early pregnancy.1 Publication

Inductioni

By progesterone.1 Publication

Gene expression databases

BgeeiENSMUSG00000041548 Expressed in 275 organ(s), highest expression level in cardiac ventricle
CleanExiMM_HSPB8
GenevisibleiQ9JK92 MM

Interactioni

Subunit structurei

Monomer. Interacts with HSPB1 (By similarity). Interacts with DNAJB6 (By similarity). Interacts with BAG3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219831, 1 interactor
IntActiQ9JK92, 2 interactors
MINTiQ9JK92
STRINGi10090.ENSMUSP00000037007

Structurei

3D structure databases

ProteinModelPortaliQ9JK92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 185sHSPPROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000233955
HOVERGENiHBG054766
InParanoidiQ9JK92
KOiK08879
OMAiPWPDWAL
OrthoDBiEOG091G0USC
PhylomeDBiQ9JK92
TreeFamiTF105049

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JK92-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADGQLPFPC SYPSRLRRDP FRDSPLSSRL LDDGFGMDPF PDDLTAPWPE
60 70 80 90 100
WALPRLSSAW PGTLRSGMVP RGPPATARFG VPAEGRSPPP FPGEPWKVCV
110 120 130 140 150
NVHSFKPEEL MVKTKDGYVE VSGKHEEKQQ EGGIVSKNFT KKIQLPAEVD
160 170 180 190
PATVFASLSP EGLLIIEAPQ VPPYSPFGES SFNNELPQDN QEVTCS
Length:196
Mass (Da):21,533
Last modified:October 1, 2000 - v1
Checksum:iADE847E9E70D7DAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250139 mRNA Translation: AAF65563.1
AF273453 mRNA Translation: AAG00233.1
AK005052 mRNA Translation: BAB23778.1
BC011219 mRNA Translation: AAH11219.1
CCDSiCCDS19600.1
RefSeqiNP_109629.1, NM_030704.3
UniGeneiMm.21549

Genome annotation databases

EnsembliENSMUST00000036991; ENSMUSP00000037007; ENSMUSG00000041548
GeneIDi80888
KEGGimmu:80888
UCSCiuc008zez.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250139 mRNA Translation: AAF65563.1
AF273453 mRNA Translation: AAG00233.1
AK005052 mRNA Translation: BAB23778.1
BC011219 mRNA Translation: AAH11219.1
CCDSiCCDS19600.1
RefSeqiNP_109629.1, NM_030704.3
UniGeneiMm.21549

3D structure databases

ProteinModelPortaliQ9JK92
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219831, 1 interactor
IntActiQ9JK92, 2 interactors
MINTiQ9JK92
STRINGi10090.ENSMUSP00000037007

PTM databases

iPTMnetiQ9JK92
PhosphoSitePlusiQ9JK92

Proteomic databases

MaxQBiQ9JK92
PaxDbiQ9JK92
PeptideAtlasiQ9JK92
PRIDEiQ9JK92

Protocols and materials databases

DNASUi80888
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036991; ENSMUSP00000037007; ENSMUSG00000041548
GeneIDi80888
KEGGimmu:80888
UCSCiuc008zez.1 mouse

Organism-specific databases

CTDi26353
MGIiMGI:2135756 Hspb8

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000233955
HOVERGENiHBG054766
InParanoidiQ9JK92
KOiK08879
OMAiPWPDWAL
OrthoDBiEOG091G0USC
PhylomeDBiQ9JK92
TreeFamiTF105049

Enzyme and pathway databases

ReactomeiR-MMU-3371571 HSF1-dependent transactivation

Miscellaneous databases

PROiPR:Q9JK92
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041548 Expressed in 275 organ(s), highest expression level in cardiac ventricle
CleanExiMM_HSPB8
GenevisibleiQ9JK92 MM

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB8_MOUSE
AccessioniPrimary (citable) accession number: Q9JK92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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