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Protein

Serpin I2

Gene

Serpini2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei357 – 358Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

  • negative regulation of endopeptidase activity Source: GO_Central
  • regulation of cell adhesion Source: MGI

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.026

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin I2
Alternative name(s):
Serine protease inhibitor 14
Gene namesi
Name:Serpini2
Synonyms:Spi14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915181 Serpini2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003252619 – 405Serpin I2Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9JK88
PaxDbiQ9JK88
PRIDEiQ9JK88

PTM databases

PhosphoSitePlusiQ9JK88

Expressioni

Tissue specificityi

Expressed in pancreas.

Gene expression databases

BgeeiENSMUSG00000034139 Expressed in 30 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiQ9JK88 baseline and differential
GenevisibleiQ9JK88 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046943

Structurei

3D structure databases

ProteinModelPortaliQ9JK88
SMRiQ9JK88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00930000150820
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiQ9JK88
OMAiWFSEMQE
OrthoDBiEOG091G0ION
PhylomeDBiQ9JK88
TreeFamiTF343094

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JK88-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKTILWSFL LFFSGSQTSR ATDQKIADFA VDLYKAISLS HKNNIIFSPL
60 70 80 90 100
GTTMLLGMVQ LGAKGKAQQQ ILKTLRMRGT PAGEEFSVLK SLFSAISKKK
110 120 130 140 150
QEFTFNLASA LYLQEGFIVK ETYLHSNKEF FQSATKLVDF LDAKTSAQAI
160 170 180 190 200
STWVESKTDG KIKNMFSEEE FGPLTRLVLV NAIYFKGDWK QKFRKEDTEM
210 220 230 240 250
TDFTKKDGST VKVPMMKALL RAQYGYFSQS SMTCQVLELP YKADEFSLVI
260 270 280 290 300
ILPTEDTSIE EVENQVTAPH VRRWFSELHE EEVEVSLPRF KIEQKLDLKE
310 320 330 340 350
ALYSLNVTEI FSGGCDLSGI TDSSEVYVSR VMQKVFFEIN EDGSEAAAST
360 370 380 390 400
GINIPAIMSL TQTQFLANHP FLFILKHIRT ESILFMGKVT DPDIQTTKGR

DLDSL
Length:405
Mass (Da):45,776
Last modified:October 1, 2000 - v1
Checksum:i04DF38BE8545DFA8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5I → M in BAB25079 (PubMed:16141072).Curated1
Sequence conflicti195K → T in BAB24976 (PubMed:16141072).Curated1
Sequence conflicti207D → S in BAB24976 (PubMed:16141072).Curated1
Sequence conflicti212 – 218KVPMMKA → RVPTDEV in BAB24976 (PubMed:16141072).Curated7
Sequence conflicti246F → Y in BAB24976 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251276 mRNA Translation: AAF65821.1
AK007347 mRNA Translation: BAB24976.1
AK007510 mRNA Translation: BAB25079.1
CCDSiCCDS17413.1
RefSeqiNP_080736.2, NM_026460.3
UniGeneiMm.259446

Genome annotation databases

EnsembliENSMUST00000039047; ENSMUSP00000046943; ENSMUSG00000034139
GeneIDi67931
KEGGimmu:67931
UCSCiuc008pna.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251276 mRNA Translation: AAF65821.1
AK007347 mRNA Translation: BAB24976.1
AK007510 mRNA Translation: BAB25079.1
CCDSiCCDS17413.1
RefSeqiNP_080736.2, NM_026460.3
UniGeneiMm.259446

3D structure databases

ProteinModelPortaliQ9JK88
SMRiQ9JK88
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046943

Protein family/group databases

MEROPSiI04.026

PTM databases

PhosphoSitePlusiQ9JK88

Proteomic databases

MaxQBiQ9JK88
PaxDbiQ9JK88
PRIDEiQ9JK88

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039047; ENSMUSP00000046943; ENSMUSG00000034139
GeneIDi67931
KEGGimmu:67931
UCSCiuc008pna.2 mouse

Organism-specific databases

CTDi5276
MGIiMGI:1915181 Serpini2

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00930000150820
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiQ9JK88
OMAiWFSEMQE
OrthoDBiEOG091G0ION
PhylomeDBiQ9JK88
TreeFamiTF343094

Miscellaneous databases

PROiPR:Q9JK88
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034139 Expressed in 30 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiQ9JK88 baseline and differential
GenevisibleiQ9JK88 MM

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPI2_MOUSE
AccessioniPrimary (citable) accession number: Q9JK88
Secondary accession number(s): Q9D8Z3, Q9D955
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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