UniProtKB - Q9JK72 (CCS_RAT)
Protein
Copper chaperone for superoxide dismutase
Gene
Ccs
Organism
Rattus norvegicus (Rat)
Status
Functioni
Delivers copper to copper zinc superoxide dismutase (SOD1).By similarity
Cofactori
Protein has several cofactor binding sites:- Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity
- Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 22 | Copper 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 25 | Copper 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 147 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 155 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 164 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 167 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 244 | Copper 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 246 | Copper 2PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- copper ion binding Source: RGD
- enzyme binding Source: RGD
- superoxide dismutase activity Source: GO_Central
- superoxide dismutase copper chaperone activity Source: RGD
GO - Biological processi
- metal ion transport Source: InterPro
- positive regulation of oxidoreductase activity Source: RGD
- removal of superoxide radicals Source: GO_Central
Keywordsi
Molecular function | Chaperone |
Ligand | Copper, Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-3299685, Detoxification of Reactive Oxygen Species |
Names & Taxonomyi
Protein namesi | Recommended name: Copper chaperone for superoxide dismutaseAlternative name(s): Superoxide dismutase copper chaperone |
Gene namesi | Name:Ccs |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620403, Ccs |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Extracellular region or secreted
- extracellular region Source: GO_Central
- extracellular space Source: GO_Central
Nucleus
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213546 | 1 – 274 | Copper chaperone for superoxide dismutaseAdd BLAST | 274 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 76 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Disulfide bondi | 141 ↔ 227 | By similarity | ||
Cross-linki | 189 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 216 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 241 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Modified residuei | 267 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241.
Keywords - PTMi
Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q9JK72 |
PaxDbi | Q9JK72 |
PRIDEi | Q9JK72 |
PTM databases
iPTMneti | Q9JK72 |
PhosphoSitePlusi | Q9JK72 |
Interactioni
Subunit structurei
Homodimer, and heterodimer with SOD1.
Interacts with COMMD1 (By similarity).
Interacts with XIAP/BIRC4 (By similarity).
By similarityGO - Molecular functioni
- enzyme binding Source: RGD
Protein-protein interaction databases
IntActi | Q9JK72, 1 interactor |
STRINGi | 10116.ENSRNOP00000065189 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 75 | HMAPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 88 – 234 | Superoxide dismutase-likeAdd BLAST | 147 |
Sequence similaritiesi
In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.Curated
Phylogenomic databases
eggNOGi | KOG4656, Eukaryota |
InParanoidi | Q9JK72 |
OrthoDBi | 1527306at2759 |
PhylomeDBi | Q9JK72 |
TreeFami | TF105184 |
Family and domain databases
CDDi | cd00305, Cu-Zn_Superoxide_Dismutase, 1 hit cd00371, HMA, 1 hit |
Gene3Di | 2.60.40.200, 1 hit |
InterProi | View protein in InterPro IPR006121, HMA_dom IPR036163, HMA_dom_sf IPR036423, SOD-like_Cu/Zn_dom_sf IPR024134, SOD_Cu/Zn_/chaperone IPR018152, SOD_Cu/Zn_BS IPR001424, SOD_Cu_Zn_dom |
PANTHERi | PTHR10003, PTHR10003, 1 hit |
Pfami | View protein in Pfam PF00403, HMA, 1 hit PF00080, Sod_Cu, 1 hit |
PRINTSi | PR00068, CUZNDISMTASE |
SUPFAMi | SSF49329, SSF49329, 1 hit SSF55008, SSF55008, 1 hit |
PROSITEi | View protein in PROSITE PS50846, HMA_2, 1 hit PS00332, SOD_CU_ZN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9JK72-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASKSGDGGT MCALEFTVQM SCQSCVDAVH KTLKGAAGVQ NVEVQLENQM
60 70 80 90 100
VLVQTTLPSQ EVQALLESTG RQAVLKGMGS SQLKNLGAAV AIMEGSGTVQ
110 120 130 140 150
GVVRFLQLSS ELCLIEGTID GLEPGLHGLH VHQYGDLTKD CSSCGDHFNP
160 170 180 190 200
DGASHGGPQD TDRHRGDLGN VHAEASGRAT FRIEDKQLKV WDVIGRSLVV
210 220 230 240 250
DEGEDDLGRG GHPLSKVTGN SGKRLACGII ARSAGLFQNP KQICSCDGLT
260 270
IWEERGRPIA GQGRKDSAQP PAHL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PSS2 | E9PSS2_RAT | Superoxide dismutase [Cu-Zn] | Ccs | 228 | Annotation score: | ||
A0A0G2JSZ9 | A0A0G2JSZ9_RAT | Copper chaperone for superoxide dis... | Ccs rCG_48323 | 274 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 99 | V → I in AAI58587 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF255305 mRNA Translation: AAF65572.1 BC158586 mRNA Translation: AAI58587.1 |
RefSeqi | NP_445877.1, NM_053425.1 |
Genome annotation databases
GeneIDi | 84485 |
KEGGi | rno:84485 |
UCSCi | RGD:620403, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF255305 mRNA Translation: AAF65572.1 BC158586 mRNA Translation: AAI58587.1 |
RefSeqi | NP_445877.1, NM_053425.1 |
3D structure databases
SMRi | Q9JK72 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9JK72, 1 interactor |
STRINGi | 10116.ENSRNOP00000065189 |
PTM databases
iPTMneti | Q9JK72 |
PhosphoSitePlusi | Q9JK72 |
Proteomic databases
jPOSTi | Q9JK72 |
PaxDbi | Q9JK72 |
PRIDEi | Q9JK72 |
Genome annotation databases
GeneIDi | 84485 |
KEGGi | rno:84485 |
UCSCi | RGD:620403, rat |
Organism-specific databases
CTDi | 9973 |
RGDi | 620403, Ccs |
Phylogenomic databases
eggNOGi | KOG4656, Eukaryota |
InParanoidi | Q9JK72 |
OrthoDBi | 1527306at2759 |
PhylomeDBi | Q9JK72 |
TreeFami | TF105184 |
Enzyme and pathway databases
Reactomei | R-RNO-3299685, Detoxification of Reactive Oxygen Species |
Miscellaneous databases
PROi | PR:Q9JK72 |
Family and domain databases
CDDi | cd00305, Cu-Zn_Superoxide_Dismutase, 1 hit cd00371, HMA, 1 hit |
Gene3Di | 2.60.40.200, 1 hit |
InterProi | View protein in InterPro IPR006121, HMA_dom IPR036163, HMA_dom_sf IPR036423, SOD-like_Cu/Zn_dom_sf IPR024134, SOD_Cu/Zn_/chaperone IPR018152, SOD_Cu/Zn_BS IPR001424, SOD_Cu_Zn_dom |
PANTHERi | PTHR10003, PTHR10003, 1 hit |
Pfami | View protein in Pfam PF00403, HMA, 1 hit PF00080, Sod_Cu, 1 hit |
PRINTSi | PR00068, CUZNDISMTASE |
SUPFAMi | SSF49329, SSF49329, 1 hit SSF55008, SSF55008, 1 hit |
PROSITEi | View protein in PROSITE PS50846, HMA_2, 1 hit PS00332, SOD_CU_ZN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCS_RAT | |
Accessioni | Q9JK72Primary (citable) accession number: Q9JK72 Secondary accession number(s): B0BMW1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families