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Protein

Mesogenin-1

Gene

Msgn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • embryonic pattern specification Source: GO_Central
  • mesoderm formation Source: GO_Central
  • segment specification Source: MGI
  • somitogenesis Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mesogenin-1
Alternative name(s):
Paraxial mesoderm-specific mesogenin1
pMesogenin1
Short name:
pMsgn1
Gene namesi
Name:Msgn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1860483 Msgn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutant animals die during gestation. Premature death starts around 10.5 dpc. Severe morphological abnormalities, such as enlarged tailbud, kinked neural tube posterior to forelimb buds and reduced tissue mass in the interlimb domain become obvious at 9.0 dpc and thereafter. Head and anterior body structures, including the developing heart, appeared normal. In the trunk posterior to the forelimbs, there are no identifiable somites or segment patterning, although the anterior-most somites appeared normal, with decreases in somite size and disruption of myotomal patterning in somites 8-11. There are no detectable somites beyond somite 11. At 11.5 dpc, myotomes are absent from the trunk at the interlimb level and at 12.5 dpc, muscle is absent from the hindlimbs. The few fetuses surviving beyond 14.5 and 17.5 pdc lack a tail and show a grossly normal, but very thin body with relatively normal forelimbs and hindlimbs. At this stage, all vertebrae posterior to cervical level together with ribs are absent, while all cervical vertebrae are present, although the most posterior ones are sometimes malformed and fused. Other trunk skeletal structures that originate from lateral mesoderm, such as the sternum and scapula, form quite normally.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003300291 – 188Mesogenin-1Add BLAST188

Proteomic databases

PaxDbiQ9JK54
PRIDEiQ9JK54

PTM databases

iPTMnetiQ9JK54
PhosphoSitePlusiQ9JK54

Expressioni

Developmental stagei

Specifically expressed in unsegmented paraxial mesoderm and its immediate progenitors and sharply down-regulated in presumptive somites. Not detectable at 6.5 dpc. At 7.5 dpc, expressed mainly in the posterior region of the embryo, lateral to the primitive streak where presumptive progenitors of paraxial mesoderm reside. Expression is largely excluded from the midline of the primitive streak. No expression is detected in the anterior part of the embryo. At 9.0 dpc, highly expressed in the caudal presomitic mesoderm. At 11.5 dpc, the primitive streak completely regresses, expression is observed exclusively in the tailbud. Expression remains in the tailbud until 13.5 dpc and begins to disappear between 13.5 and 14.5 dpc when the tailbud loses its potential to provide paraxial mesoderm cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000047002 Expressed in 11 organ(s), highest expression level in presomitic mesoderm
GenevisibleiQ9JK54 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055001

Structurei

3D structure databases

ProteinModelPortaliQ9JK54
SMRiQ9JK54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 172bHLHPROSITE-ProRule annotationAdd BLAST55

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00530000063712
HOGENOMiHOG000070445
HOVERGENiHBG105692
InParanoidiQ9JK54
KOiK09077
OMAiSSWDWKN
OrthoDBiEOG091G0N6N
PhylomeDBiQ9JK54
TreeFamiTF325707

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JK54-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNLGETFLS LEDGLDSSDT AGLLASWDWK SRARPLELVQ ESPTQSLSPA
60 70 80 90 100
PSLESYSEVA LPCGHSGAST GGSDGYGSHE AAGLVELDYS MLAFQPPYLH
110 120 130 140 150
TAGGLKGQKG SKVKMSVQRR RKASEREKLR MRTLADALHT LRNYLPPVYS
160 170 180
QRGQPLTKIQ TLKYTIKYIG ELTDLLNSSG REPRPQSV
Length:188
Mass (Da):20,553
Last modified:October 1, 2000 - v1
Checksum:iB31A67067630E322
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261105 mRNA Translation: AAF70375.1
BC116996 mRNA Translation: AAI16997.1
CCDSiCCDS25814.1
RefSeqiNP_062417.1, NM_019544.1
UniGeneiMm.117113

Genome annotation databases

EnsembliENSMUST00000049877; ENSMUSP00000055001; ENSMUSG00000047002
GeneIDi56184
KEGGimmu:56184
UCSCiuc007nau.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMSGN1_MOUSE
AccessioniPrimary (citable) accession number: Q9JK54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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