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Protein

Prolargin

Gene

Prelp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May anchor basement membranes to the underlying connective tissue.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell aging Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-2022854 Keratan sulfate biosynthesis
R-MMU-2022857 Keratan sulfate degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Prolargin
Alternative name(s):
Proline-arginine-rich end leucine-rich repeat protein
Gene namesi
Name:Prelp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2151110 Prelp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003274522 – 378ProlarginAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi328 ↔ 369By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9JK53
PaxDbiQ9JK53
PRIDEiQ9JK53

PTM databases

PhosphoSitePlusiQ9JK53

Expressioni

Tissue specificityi

Expressed in cartilage throughout both fetal development and postnatal life. It is also expressed in the developing embryo prior to skeletogenesis. In adult, highest expression in lung, lower levels in cardiac and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000041577 Expressed in 205 organ(s), highest expression level in epididymal fat pad
CleanExiMM_PRELP
ExpressionAtlasiQ9JK53 baseline and differential
GenevisibleiQ9JK53 MM

Interactioni

Subunit structurei

Binds the basement membrane heparan sulfate proteoglycan perlecan and triple helical collagens type I and type II.By similarity

Protein-protein interaction databases

IntActiQ9JK53, 1 interactor
MINTiQ9JK53
STRINGi10090.ENSMUSP00000048803

Structurei

3D structure databases

ProteinModelPortaliQ9JK53
SMRiQ9JK53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati91 – 110LRR 1Add BLAST20
Repeati111 – 134LRR 2Add BLAST24
Repeati135 – 158LRR 3Add BLAST24
Repeati159 – 179LRR 4Add BLAST21
Repeati180 – 203LRR 5Add BLAST24
Repeati204 – 229LRR 6Add BLAST26
Repeati230 – 250LRR 7Add BLAST21
Repeati251 – 274LRR 8Add BLAST24
Repeati275 – 299LRR 9Add BLAST25
Repeati300 – 319LRR 10Add BLAST20
Repeati320 – 358LRR 11Add BLAST39
Repeati359 – 378LRR 12Add BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi69 – 85Cys-richAdd BLAST17
Compositional biasi193 – 198Poly-Leu6

Domaini

The basic N-terminal Arg/Pro-rich binds heparin and heparan sulfate. Binds collagens type I and type II through its leucine-rich repeat domain (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000234447
HOVERGENiHBG108061
InParanoidiQ9JK53
KOiK08125
OMAiVPAINNK
OrthoDBiEOG091G09Q0
PhylomeDBiQ9JK53
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR027216 Prolargin
PANTHERiPTHR24373:SF152 PTHR24373:SF152, 1 hit
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JK53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRASFFWLLP LLLILASVAQ GQPTRPKPGI RRKPKPRPTP RFPQAPEPAE
60 70 80 90 100
PTDLPPPLPP GPPSVFPDCP RECYCPPDFP SALYCDSRNL RRVPVIPPRI
110 120 130 140 150
HYLYLQNNFI TELPLESFQN ATGLRWVNLD NNRIRKVDQR VLGKLPSLAF
160 170 180 190 200
LYMEKNQLEE VPSALPRNLE QLRLSQNLIS RIPPGVFSKL ENLLLLDLQH
210 220 230 240 250
NRLSDGVFKA DTFQGLKNLM QLNLAHNILR KMPPKVPQAI HQLYLDSNKI
260 270 280 290 300
ETIPNGYFKD FPNLAFIRMN YNKLSDRGLP KNSFNISNLL VLHLSHNKIS
310 320 330 340 350
NVPAISNKLE HLYLNNNSIE KINGTQICPN NLVAFHDFSS DLENVPHLRY
360 370
LRLDGNFLKP PIPLDLMMCF RLLQSVVI
Length:378
Mass (Da):43,293
Last modified:June 1, 2001 - v2
Checksum:i81654FB9D5F55186
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261888, AF261887 Genomic DNA Translation: AAF72994.2
BC019775 mRNA Translation: AAH19775.1
CCDSiCCDS15300.1
RefSeqiNP_473418.3, NM_054077.4
XP_006529147.1, XM_006529084.3
XP_006529148.1, XM_006529085.3
UniGeneiMm.214514

Genome annotation databases

EnsembliENSMUST00000048432; ENSMUSP00000048803; ENSMUSG00000041577
GeneIDi116847
KEGGimmu:116847
UCSCiuc007crc.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261888, AF261887 Genomic DNA Translation: AAF72994.2
BC019775 mRNA Translation: AAH19775.1
CCDSiCCDS15300.1
RefSeqiNP_473418.3, NM_054077.4
XP_006529147.1, XM_006529084.3
XP_006529148.1, XM_006529085.3
UniGeneiMm.214514

3D structure databases

ProteinModelPortaliQ9JK53
SMRiQ9JK53
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JK53, 1 interactor
MINTiQ9JK53
STRINGi10090.ENSMUSP00000048803

PTM databases

PhosphoSitePlusiQ9JK53

Proteomic databases

MaxQBiQ9JK53
PaxDbiQ9JK53
PRIDEiQ9JK53

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048432; ENSMUSP00000048803; ENSMUSG00000041577
GeneIDi116847
KEGGimmu:116847
UCSCiuc007crc.3 mouse

Organism-specific databases

CTDi5549
MGIiMGI:2151110 Prelp

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000234447
HOVERGENiHBG108061
InParanoidiQ9JK53
KOiK08125
OMAiVPAINNK
OrthoDBiEOG091G09Q0
PhylomeDBiQ9JK53
TreeFamiTF334562

Enzyme and pathway databases

ReactomeiR-MMU-2022854 Keratan sulfate biosynthesis
R-MMU-2022857 Keratan sulfate degradation

Miscellaneous databases

PROiPR:Q9JK53
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041577 Expressed in 205 organ(s), highest expression level in epididymal fat pad
CleanExiMM_PRELP
ExpressionAtlasiQ9JK53 baseline and differential
GenevisibleiQ9JK53 MM

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR027216 Prolargin
PANTHERiPTHR24373:SF152 PTHR24373:SF152, 1 hit
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPRELP_MOUSE
AccessioniPrimary (citable) accession number: Q9JK53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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