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Protein

Potassium voltage-gated channel subfamily KQT member 5

Gene

Kcnq5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current.1 Publication

Miscellaneous

The activity of this channel is modulated by zinc, pH and volume changes.1 Publication

GO - Molecular functioni

  • calmodulin binding Source: GO_Central
  • delayed rectifier potassium channel activity Source: GO_Central
  • voltage-gated potassium channel activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Protein family/group databases

TCDBi1.A.1.15.5 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily KQT member 5
Alternative name(s):
KQT-like 5
Potassium channel subunit alpha KvLQT5
Voltage-gated potassium channel subunit Kv7.5
Gene namesi
Name:Kcnq5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1924937 Kcnq5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 126CytoplasmicSequence analysisAdd BLAST126
Transmembranei127 – 147Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini148 – 157ExtracellularSequence analysis10
Transmembranei158 – 178Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini179 – 201CytoplasmicSequence analysisAdd BLAST23
Transmembranei202 – 222Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini223 – 230ExtracellularSequence analysis8
Transmembranei231 – 253Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST23
Topological domaini254 – 267CytoplasmicSequence analysisAdd BLAST14
Transmembranei268 – 288Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini289 – 299ExtracellularSequence analysisAdd BLAST11
Intramembranei300 – 320Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini321 – 326ExtracellularSequence analysis6
Transmembranei327 – 347Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini348 – 933CytoplasmicSequence analysisAdd BLAST586

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540411 – 933Potassium voltage-gated channel subfamily KQT member 5Add BLAST933

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89PhosphoserineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei832PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JK45
PRIDEiQ9JK45

PTM databases

iPTMnetiQ9JK45
PhosphoSitePlusiQ9JK45

Expressioni

Gene expression databases

BgeeiENSMUSG00000028033 Expressed in 192 organ(s), highest expression level in hippocampal field
ExpressionAtlasiQ9JK45 baseline and differential
GenevisibleiQ9JK45 MM

Interactioni

Subunit structurei

Heteromultimer with KCNQ3. Heterotetramer with KCNQ1; has a voltage-gated potassium channel activity.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110955

Structurei

3D structure databases

ProteinModelPortaliQ9JK45
SMRiQ9JK45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi312 – 317Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1419 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00550000074513
HOGENOMiHOG000220839
HOVERGENiHBG059014
InParanoidiQ9JK45
KOiK04930
PhylomeDBiQ9JK45

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR003937 K_chnl_volt-dep_KCNQ
IPR013821 K_chnl_volt-dep_KCNQ_C
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF03520 KCNQ_channel, 1 hit
PRINTSiPR00169 KCHANNEL
PR01459 KCNQCHANNEL

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9JK45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRHHAGGEE GGAAGLWVRS GAAAAAGAGG GRPGSGMKDV ESGRGRVLLN
60 70 80 90 100
SAAARGDGLL LLGTRAAALG GGGGGLRESR RGKQGARMSL LGKPLSYTSS
110 120 130 140 150
QSCRRNVKYR RVQNYLYNVL ERPRGWAFVY HAFVFLLVFG CLILSVFSTI
160 170 180 190 200
PEHTKLASSC LLILEFVMIV VFGLEFIIRI WSAGCCCRYR GWQGRLRFAR
210 220 230 240 250
KPFCVIDTIV LIASIAVVSA KTQGNIFATS ALRSLRFLQI LRMVRMDRRG
260 270 280 290 300
GTWKLLGSVV YAHSKELITA WYIGFLVLIF SSFLVYLVEK DANKEFSTYA
310 320 330 340 350
DALWWGTITL TTIGYGDKTP LTWLGRLLSA GFALLGISFF ALPAGILGSG
360 370 380 390 400
FALKVQEQHR QKHFEKRRNP AANLIQCVWR SYAADEKSVS IATWKPHLKA
410 420 430 440 450
LHTCSPTKKE QGEASSSQKL SFKERVRMAS PRGQSIKSRQ ASVGDRRSPS
460 470 480 490 500
TDITAEGSPT KVQKSWSFND RTRFRPSLRL KSSQPKPVID ADTALGIDDV
510 520 530 540 550
YDEKGCQCDV SVEDLTPPLK TVIRAIRIMK FHVAKRKFKE TLRPYDVKDV
560 570 580 590 600
IEQYSAGHLD MLCRIKSLQT RVDQILGKGQ MTSDKKSREK ITAEHETTDD
610 620 630 640 650
PSMLARVVKV EKQVQSIESK LDCLLDIYQQ VLRKGSASAL TLASFQIPPF
660 670 680 690 700
ECEQTSDYQS PVDSKDLSGS AQNSGCLTRS ASANISRGLQ FILTPNEFSA
710 720 730 740 750
QTFYALSPTM HSQATQVPMS QNDGSSVVAT NNIANQISAA PKPAAPTTLQ
760 770 780 790 800
IPPPLSAIKH LSRPEPLLSN PTGLQESISD VTTCLVASKE SVQFAQSNLT
810 820 830 840 850
KDRSLRKSFD MGGETLLSVR PMVPKDLGKS LSVQNLIRST EELNLQFSGS
860 870 880 890 900
ESSGSRGSQD FYPKWRESKL FITDEEVGAE ETETDTFDGT PPPAGEAAFS
910 920 930
SDSLRTGRSR SSQNICKTGD STDALSLPHV KLN
Length:933
Mass (Da):102,258
Last modified:January 9, 2007 - v2
Checksum:i92B8C314D7144288
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q9F1E9Q9F1_MOUSE
Potassium voltage-gated channel sub...
Kcnq5
952Annotation score:
G3UYG5G3UYG5_MOUSE
Potassium voltage-gated channel sub...
Kcnq5
924Annotation score:
G3UYP4G3UYP4_MOUSE
Potassium voltage-gated channel sub...
Kcnq5
823Annotation score:
G3UZ84G3UZ84_MOUSE
Potassium voltage-gated channel sub...
Kcnq5
172Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti636S → Y in BAC28145 (PubMed:16141072).Curated1
Sequence conflicti923D → G in BAC28145 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY679158 mRNA Translation: AAT76442.1
AF263836 mRNA Translation: AAF73447.1
AK033079 mRNA Translation: BAC28145.1
CCDSiCCDS35525.1
RefSeqiNP_076361.1, NM_023872.3
UniGeneiMm.336519
Mm.403737

Genome annotation databases

EnsembliENSMUST00000029667; ENSMUSP00000029667; ENSMUSG00000028033
GeneIDi226922
KEGGimmu:226922
UCSCiuc007alq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY679158 mRNA Translation: AAT76442.1
AF263836 mRNA Translation: AAF73447.1
AK033079 mRNA Translation: BAC28145.1
CCDSiCCDS35525.1
RefSeqiNP_076361.1, NM_023872.3
UniGeneiMm.336519
Mm.403737

3D structure databases

ProteinModelPortaliQ9JK45
SMRiQ9JK45
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110955

Protein family/group databases

TCDBi1.A.1.15.5 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiQ9JK45
PhosphoSitePlusiQ9JK45

Proteomic databases

PaxDbiQ9JK45
PRIDEiQ9JK45

Protocols and materials databases

DNASUi226922
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029667; ENSMUSP00000029667; ENSMUSG00000028033
GeneIDi226922
KEGGimmu:226922
UCSCiuc007alq.2 mouse

Organism-specific databases

CTDi56479
MGIiMGI:1924937 Kcnq5

Phylogenomic databases

eggNOGiKOG1419 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00550000074513
HOGENOMiHOG000220839
HOVERGENiHBG059014
InParanoidiQ9JK45
KOiK04930
PhylomeDBiQ9JK45

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Miscellaneous databases

PROiPR:Q9JK45
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028033 Expressed in 192 organ(s), highest expression level in hippocampal field
ExpressionAtlasiQ9JK45 baseline and differential
GenevisibleiQ9JK45 MM

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR003937 K_chnl_volt-dep_KCNQ
IPR013821 K_chnl_volt-dep_KCNQ_C
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF03520 KCNQ_channel, 1 hit
PRINTSiPR00169 KCHANNEL
PR01459 KCNQCHANNEL
ProtoNetiSearch...

Entry informationi

Entry nameiKCNQ5_MOUSE
AccessioniPrimary (citable) accession number: Q9JK45
Secondary accession number(s): Q4QXS5, Q8BSF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 9, 2007
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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