Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
1 to 25 of 33  Show
  1. 1
    "Mus musculus pyruvate dehydrogenase kinase 2 cDNA."
    Jeoung N.H., Harris R.A.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Category: Sequences.
    Strain: C57BL/6J.
    Source: UniProtKB/Swiss-Prot (reviewed).
  2. 2
    Category: Sequences.
    Strain: C57BL/6J.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 43064 other entries.

  3. 3
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  4. 4
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Category: Sequences.
    Tissue: Mammary tumor.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50448 other entries.

  5. 5
    "Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets."
    Xu J., Han J., Epstein P.N., Liu Y.Q.
    Biochem. Biophys. Res. Commun. 344:827-833(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY PALMITATE AND GLUCOSE.
    Category: Expression.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 other entry.

  6. 6
    "Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta."
    Degenhardt T., Saramaki A., Malinen M., Rieck M., Vaisanen S., Huotari A., Herzig K.H., Muller R., Carlberg C.
    J. Mol. Biol. 372:341-355(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY PPARD.
    Category: Expression.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 4 and mapped to 15 other entries.

  7. 7
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 25326 other entries.

  8. 8
    "PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation."
    Dunford E.C., Herbst E.A., Jeoung N.H., Gittings W., Inglis J.G., Vandenboom R., LeBlanc P.J., Harris R.A., Peters S.J.
    Am. J. Physiol. 300:R1487-R1493(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
    Category: Pathology & Biotech.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 2 other entries.

  9. 9
    "Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart."
    Ushikai M., Horiuchi M., Kobayashi K., Matuda S., Inui A., Takeuchi T., Saheki T.
    Mol. Genet. Metab. 102:349-355(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Category: Subcellular Location, Expression, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 4 other entries.

  10. 10
    "Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice."
    Jeoung N.H., Rahimi Y., Wu P., Lee W.N., Harris R.A.
    Biochem. J. 443:829-839(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
    Category: Function, Pathology & Biotech.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 1 other entries.

  11. 11
    Category: Sequences.
    Source: MGI:1343087.

    This publication is cited by 16981 and mapped to 30126 other entries.

  12. 12
    "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T.
    Hayashizaki Y.
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:1343087.

    This publication is cited by 16984 and mapped to 41260 other entries.

  13. 13
    "Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria."
    Mootha V.K., Bunkenborg J., Olsen J.V., Hjerrild M., Wisniewski J.R., Stahl E., Bolouri M.S., Ray H.N., Sihag S., Kamal M., Patterson N., Lander E.S., Mann M.
    Cell 115:629-640(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location, Expression.
    Source: MGI:1343087.

    This publication is mapped to 1904 other entries.

  14. 14
    Category: Function, Interaction.
    Source: IntAct:Q9JK42, MGI:1343087.

    This publication is mapped to 1296 other entries.

  15. 15
    "Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling."
    Kislinger T., Cox B., Kannan A., Chung C., Hu P., Ignatchenko A., Scott M.S., Gramolini A.O., Morris Q., Hallett M.T., Rossant J., Hughes T.R., Frey B., Emili A.
    Cell 125:173-186(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Source: IntAct:Q9JK42.

    This publication is mapped to 4102 other entries.

  16. 16
    Category: Subcellular Location.
    Source: MGI:1343087.

    This publication is cited by 8 and mapped to 3684 other entries.

  17. 17
    "Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma."
    Sun W., Zhou S., Chang S.S., McFate T., Verma A., Califano J.A.
    Clin. Cancer Res. 15:476-484(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: mitochondrial ND2 mutation contributes to HIF1alpha accumulation via increased ROS production up-regulation of PDK2 attenuating PDH activity thereby increasing pyruvate resulting in HIF1alpha stabilization.
    Source: GeneRIF:18604.

    This publication is mapped to 17 other entries.

  18. 18
    Category: Expression.
    Source: MGI:1343087.

    This publication is mapped to 50335 other entries.

  19. 19
    "p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2."
    Contractor T., Harris C.R.
    Cancer Res. 72:560-567(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Results established that wild-type p53 prevents manifestation of the Warburg effect by controlling Pdk2. These findings elucidate a new mechanism by which p53 suppresses tumorigenesis acting at the level of cancer cell metabolism. [GeneRIF:18604].
    Source: GeneRIF:18604, MGI:1343087.

    This publication is mapped to 206 other entries.

  20. 20
    Category: Function.
    Source: MGI:1343087.

    This publication is mapped to 28 other entries.

  21. 21
    "Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells."
    Takubo K., Nagamatsu G., Kobayashi C.I., Nakamura-Ishizu A., Kobayashi H., Ikeda E., Goda N., Rahimi Y., Johnson R.S., Soga T., Hirao A., Suematsu M., Suda T.
    Cell Stem Cell 12:49-61(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: loss of both Pdk2 and Pdk4 attenuated HSC quiescence glycolysis and transplantation capacity. [GeneRIF:18604].
    Source: GeneRIF:18604, MGI:1343087.

    This publication is mapped to 11 other entries.

  22. 22
    "Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left-right axis formation."
    Takao D., Nemoto T., Abe T., Kiyonari H., Kajiura-Kobayashi H., Shiratori H., Nonaka S.
    Dev. Biol. 376:23-30(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Source: MGI:1343087.

    This publication is mapped to 4 other entries.

  23. 23
    "Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes."
    Tao R., Xiong X., Harris R.A., White M.F., Dong X.C.
    PLoS ONE 8:e71997-e71997(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: The Pdk4 gene knockdown led to better glucose tolerance than the Pdk2 gene knockdown. [GeneRIF:18604].
    Source: GeneRIF:18604, MGI:1343087.

    This publication is mapped to 7 other entries.

  24. 24
    "Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket."
    Tso S.C., Qi X., Gui W.J., Wu C.Y., Chuang J.L., Wernstedt-Asterholm I., Morlock L.K., Owens K.R., Scherer P.E., Williams N.S., Tambar U.K., Wynn R.M., Chuang D.T.
    J. Biol. Chem. 289:4432-4443(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Annotation: The final compound of this series 2-[(2 4-dihydroxyphenyl)sulfonyl].
    Source: GeneRIF:18604.

    This publication is mapped to 3 other entries.

  25. 25
    "Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease."
    Harris P.C., Torres V.E.
    J. Clin. Invest. 124:2315-2324(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Source: MGI:1343087.

    This publication is mapped to 1 other entry.

1 to 25 of 33  Show
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again