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Protein

High affinity copper uptake protein 1

Gene

Slc31a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

High-affinity, saturable copper transporter involved in dietary copper uptake.1 Publication

GO - Molecular functioni

  • copper ion transmembrane transporter activity Source: RGD
  • identical protein binding Source: Ensembl

GO - Biological processi

  • cellular copper ion homeostasis Source: RGD
  • cellular response to cisplatin Source: RGD
  • copper ion import Source: RGD
  • copper ion import across plasma membrane Source: RGD
  • drug transmembrane transport Source: RGD

Keywordsi

Biological processCopper transport, Ion transport, Transport
LigandCopper

Enzyme and pathway databases

ReactomeiR-RNO-425410 Metal ion SLC transporters

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity copper uptake protein 1
Alternative name(s):
Copper transporter 1
Short name:
rCTR1
Liver regeneration-related protein LRRGT00200
Solute carrier family 31 member 1
Gene namesi
Name:Slc31a1
Synonyms:Copt1, Ctr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620059 Slc31a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 65ExtracellularSequence analysisAdd BLAST65
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 129CytoplasmicSequence analysisAdd BLAST43
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 153ExtracellularSequence analysis3
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 187CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950421 – 187High affinity copper uptake protein 1Add BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi30O-linked (GalNAc...) threonineBy similarity1
Modified residuei111PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JK41
PRIDEiQ9JK41

PTM databases

PhosphoSitePlusiQ9JK41

Expressioni

Gene expression databases

BgeeiENSRNOG00000014475
GenevisibleiQ9JK41 RN

Interactioni

Subunit structurei

Homotrimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019544

Structurei

3D structure databases

SMRiQ9JK41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3386 Eukaryota
ENOG4111I8D LUCA
GeneTreeiENSGT00530000063415
HOGENOMiHOG000195393
HOVERGENiHBG065767
InParanoidiQ9JK41
KOiK14686
OMAiCIVFRQW
OrthoDBiEOG091G0VVR
PhylomeDBiQ9JK41

Family and domain databases

InterProiView protein in InterPro
IPR007274 Cop_transporter
PANTHERiPTHR12483 PTHR12483, 1 hit
PfamiView protein in Pfam
PF04145 Ctr, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JK41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMNHMEMHH MGMNHTDDNI TMPPHQHPTT SASHSHEMMM PMTFYFGFKN
60 70 80 90 100
VDLLFSSLVI NTPGEMAGAF VAVFLLAMFY EGLKIAREGL LRKSQVSIRY
110 120 130 140 150
NSMPVPGPNG TILMETHKTV GQQMLSFPHL LQTVLHIIQV VISYFLMLIF
160 170 180
MTYNGYLCIA VAAGAGTGYF LFSWKKAVVV DITEHCH
Length:187
Mass (Da):21,129
Last modified:October 1, 2000 - v1
Checksum:i05CA4A45A543F5D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268030 mRNA Translation: AAF72546.1
AY539951 mRNA Translation: AAS66291.1
BC078745 mRNA Translation: AAH78745.1
RefSeqiNP_598284.1, NM_133600.1
UniGeneiRn.2789
Rn.95113

Genome annotation databases

EnsembliENSRNOT00000019544; ENSRNOP00000019544; ENSRNOG00000014475
GeneIDi171135
KEGGirno:171135
UCSCiRGD:620059 rat

Similar proteinsi

Entry informationi

Entry nameiCOPT1_RAT
AccessioniPrimary (citable) accession number: Q9JK41
Secondary accession number(s): Q53YN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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