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Protein

Myozenin-1

Gene

Myoz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.2 PublicationsCurated

GO - Molecular functioni

  • actin binding Source: GO_Central
  • FATZ binding Source: MGI
  • telethonin binding Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Myozenin-1
Alternative name(s):
Calsarcin-2
Filamin-, actinin- and telethonin-binding protein
Protein FATZ
Gene namesi
Name:Myoz1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1929471 Myoz1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001110961 – 296Myozenin-1Add BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JK37
PaxDbiQ9JK37
PRIDEiQ9JK37

PTM databases

iPTMnetiQ9JK37
PhosphoSitePlusiQ9JK37

Expressioni

Tissue specificityi

Expressed primarily in skeletal muscle and specifically enriched in the gastrocnemius, which is composed predominantly of fast-twitch muscle fibers. Detected at lower levels in heart.2 Publications

Developmental stagei

At E9.5, expressed at significant levels in cardiac muscle with lower levels detected in skeletal muscle of tongue. At E15.5, cardiac expression is down-regulated and only weakly detected in atria, whereas skeletal muscle expression is more robust.1 Publication

Gene expression databases

BgeeiENSMUSG00000068697 Expressed in 130 organ(s), highest expression level in knee joint
CleanExiMM_MYOZ1
GenevisibleiQ9JK37 MM

Interactioni

Subunit structurei

Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA and TCAP. Interacts via its C-terminal region with MYOT.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087955

Structurei

3D structure databases

ProteinModelPortaliQ9JK37
SMRiQ9JK37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi95 – 172Gly-richSequence analysisAdd BLAST78

Sequence similaritiesi

Belongs to the myozenin family.Curated

Phylogenomic databases

eggNOGiENOG410IICS Eukaryota
ENOG4111KTQ LUCA
GeneTreeiENSGT00530000063184
HOGENOMiHOG000030910
HOVERGENiHBG071289
InParanoidiQ9JK37
OMAiMFKLRQL
OrthoDBiEOG091G0GA9
PhylomeDBiQ9JK37
TreeFamiTF331748

Family and domain databases

InterProiView protein in InterPro
IPR008438 MYOZ
PANTHERiPTHR15941 PTHR15941, 1 hit
PfamiView protein in Pfam
PF05556 Calsarcin, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JK37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLSGTPAPN KRRKSSKLIM ELTGGGRESS GLNLGKKISV PRDVMLEELS
60 70 80 90 100
LLTNRGSKMF KLRQMRVEKF IYENHPDVFS DSSMDHFQKF LPTVGGQLET
110 120 130 140 150
AGQGFSYGKG SSGGQAGSSG SAGQYGSDRH QQGSGFGAGG SGGPGGQAGG
160 170 180 190 200
GGAPGTVGLG EPGSGDQAGG DGKHVTVFKT YISPWDRAMG VDPQQKVELG
210 220 230 240 250
IDLLAYGAKA ELPKYKSFNR TAMPYGGYEK ASKRMTFQMP KFDLGPLLSE
260 270 280 290
PLVLYNQNLS NRPSFNRTPI PWLSSGEHVD YNVDVGIPLD GETEEL
Length:296
Mass (Da):31,457
Last modified:October 1, 2000 - v1
Checksum:iE9D16F4723B1EE83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100T → A in BAB26059 (PubMed:16141072).Curated1
Sequence conflicti131Q → H in BAC31092 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005620 mRNA Translation: CAB76836.1
AY013298 mRNA Translation: AAG38941.1
AK009077 mRNA Translation: BAB26059.1
AK041896 mRNA Translation: BAC31092.1
BC024660 mRNA Translation: AAH24660.1
CCDSiCCDS36819.1
RefSeqiNP_067483.1, NM_021508.3
UniGeneiMm.439911

Genome annotation databases

EnsembliENSMUST00000090469; ENSMUSP00000087955; ENSMUSG00000068697
GeneIDi59011
KEGGimmu:59011
UCSCiuc007skd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005620 mRNA Translation: CAB76836.1
AY013298 mRNA Translation: AAG38941.1
AK009077 mRNA Translation: BAB26059.1
AK041896 mRNA Translation: BAC31092.1
BC024660 mRNA Translation: AAH24660.1
CCDSiCCDS36819.1
RefSeqiNP_067483.1, NM_021508.3
UniGeneiMm.439911

3D structure databases

ProteinModelPortaliQ9JK37
SMRiQ9JK37
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087955

PTM databases

iPTMnetiQ9JK37
PhosphoSitePlusiQ9JK37

Proteomic databases

MaxQBiQ9JK37
PaxDbiQ9JK37
PRIDEiQ9JK37

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090469; ENSMUSP00000087955; ENSMUSG00000068697
GeneIDi59011
KEGGimmu:59011
UCSCiuc007skd.1 mouse

Organism-specific databases

CTDi58529
MGIiMGI:1929471 Myoz1

Phylogenomic databases

eggNOGiENOG410IICS Eukaryota
ENOG4111KTQ LUCA
GeneTreeiENSGT00530000063184
HOGENOMiHOG000030910
HOVERGENiHBG071289
InParanoidiQ9JK37
OMAiMFKLRQL
OrthoDBiEOG091G0GA9
PhylomeDBiQ9JK37
TreeFamiTF331748

Miscellaneous databases

ChiTaRSiMyoz1 mouse
PROiPR:Q9JK37
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068697 Expressed in 130 organ(s), highest expression level in knee joint
CleanExiMM_MYOZ1
GenevisibleiQ9JK37 MM

Family and domain databases

InterProiView protein in InterPro
IPR008438 MYOZ
PANTHERiPTHR15941 PTHR15941, 1 hit
PfamiView protein in Pfam
PF05556 Calsarcin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYOZ1_MOUSE
AccessioniPrimary (citable) accession number: Q9JK37
Secondary accession number(s): Q8C9L3, Q9D7N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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