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Entry version 121 (22 Apr 2020)
Sequence version 2 (30 Nov 2016)
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Protein

CAP-Gly domain-containing linker protein 1

Gene

Clip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1299 – 1316CCHC-typeBy similarityAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-RNO-2467813 Separation of Sister Chromatids
R-RNO-2500257 Resolution of Sister Chromatid Cohesion
R-RNO-5626467 RHO GTPases activate IQGAPs
R-RNO-5663220 RHO GTPases Activate Formins
R-RNO-68877 Mitotic Prometaphase
R-RNO-9648025 EML4 and NUDC in mitotic spindle formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CAP-Gly domain-containing linker protein 1
Alternative name(s):
Cytoplasmic linker protein 1703 Publications
Short name:
CLIP-1703 Publications
Restin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Clip1
Synonyms:Cyln1, Rsn
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Rat genome database

More...
RGDi
67404 Clip1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi309S → A: Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-311; A-313; A-319 and A-320. 2 Publications1
Mutagenesisi309S → E: Phosphomimetic mutant which exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-311; E-313; E-319 and E-320. 2 Publications1
Mutagenesisi311S → A: Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-309; A-313; A-319 and A-320. 2 Publications1
Mutagenesisi311S → E: Phosphomimetic mutant which exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-309; E-313; E-319 and E-320. 2 Publications1
Mutagenesisi313S → A: Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-309; A-311; A-319 and A-320. 2 Publications1
Mutagenesisi313S → E: Phosphomimetic mutant which exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-309; E-311; E-319 and E-320. 2 Publications1
Mutagenesisi319S → A: Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-309; A-311; A-313 and A-320. 2 Publications1
Mutagenesisi319S → E: Phosphomimetic mutant which exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-30; E-311; E-313 and E-320. 2 Publications1
Mutagenesisi320S → A: Phosphodeficient mutant which exhibits an open conformation with a high affinity for microtubules and DCTN1; when associated with A-309; A-311; A-313 and A-319. 2 Publications1
Mutagenesisi320S → E: Phosphomimetic mutant, exhibits a closed autoinhibited conformation with a low affinity for microtubules and DCTN1; when associated with E-309; E-311; E-313 and E-319. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004383221 – 1320CAP-Gly domain-containing linker protein 1Add BLAST1320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei48PhosphoserineBy similarity1
Modified residuei50PhosphothreonineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Modified residuei181PhosphothreonineBy similarity1
Modified residuei194PhosphoserineCombined sources1
Modified residuei196PhosphoserineBy similarity1
Modified residuei199PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei309PhosphoserineCombined sources1 Publication1
Modified residuei311Phosphoserine; by PKA1 Publication1
Modified residuei314Phosphoserine1 Publication1
Modified residuei347Phosphoserine1 Publication1
Modified residuei1116PhosphoserineCombined sources1
Modified residuei1246PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation induces conformational changes by increasing the affinity of the N-terminus for C-terminus, resulting in inhibition of its function thus decreasing its binding to microtubules and DCTN1. Exhibits a folded, autoinhibited conformation when phosphorylated and an open conformation when dephosphorylated with increased binding affinity to microtubules and DCTN1. Phosphorylation regulates its recruitment to tyrosinated microtubules and the recruitment of vesicular cargo to microtubules in neurons (PubMed:20519438, PubMed:26972003). Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules (By similarity).By similarity2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9JK25

PRoteomics IDEntifications database

More...
PRIDEi
Q9JK25

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JK25

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JK25

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001247 Expressed in skeletal muscle tissue and 8 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9JK25 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JK25 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MTOR; phosphorylates and regulates CLIP1.

Interacts (via CAP-Gly domains) with tubulin and TUBA1B.

Interacts with SLAIN2.

Interacts with MAPRE1 and MAPRE3 (By similarity).

Interacts (via zinc finger) with DCTN1 (PubMed:20519438, PubMed:26972003). Binds preferentially to tyrosinated microtubules, and only marginally to detyrosinated microtubules (PubMed:26972003).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9JK25, 9 interactors

Molecular INTeraction database

More...
MINTi
Q9JK25

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000001685

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9JK25

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 120CAP-Gly 1PROSITE-ProRule annotationAdd BLAST43
Domaini231 – 273CAP-Gly 2PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni97 – 101Important for tubulin bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi305 – 330Ser-richPROSITE-ProRule annotationAdd BLAST26

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction with tubulin.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1299 – 1316CCHC-typeBy similarityAdd BLAST18

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4568 Eukaryota
COG5244 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155122

KEGG Orthology (KO)

More...
KOi
K10421

Database of Orthologous Groups

More...
OrthoDBi
1110101at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JK25

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.190, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR032108 CLIP1_ZNF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01302 CAP_GLY, 2 hits
PF16641 CLIP1_ZNF, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01052 CAP_GLY, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74924 SSF74924, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00845 CAP_GLY_1, 2 hits
PS50245 CAP_GLY_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9JK25-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMLKPSGLK APTKILKPGS TALKTPAAAA APLEKTVPSE KASGPPSSET
60 70 80 90 100
QEEFVDDFRV GERVWVNGNK PGFIQFLGET QFAPGQWAGI VLDEPIGKND
110 120 130 140 150
GSVAGVRYFQ CEPLKGIFTR PSKLTRKVQA EDEANGLQTA HARAASPLST
160 170 180 190 200
AAATMVSSSP ATPSNIPQKP SQPVAKETSA TPQISNLTKT ASESISNLSE
210 220 230 240 250
AGSVKKGERE LKIGDRVLVG GTKAGVVRFL GETDFAKGEW CGVELDEPLG
260 270 280 290 300
KNDGAVAGTR YFQCQPKYGL FAPVHKVTKI GFPSTTPAKA KAAAVRRVMA
310 320 330 340 350
TTPASLKRSP SASSLSSMSS VASSVSSKPS RTGLLTETSS RYARKISGTT
360 370 380 390 400
ALQEALKEKQ QHIEQLLAER DLERAEVAKA TSHVGEIEQE LALARDGHDQ
410 420 430 440 450
HVLELEAKMD QLRTMVEAAD REKVELLNQL EEEKRKVEDL QFRVEEESIT
460 470 480 490 500
KGDLETQTKL EHARIKELEQ SLLFEKTKAD KLQRELEDTR VATVSEKSRI
510 520 530 540 550
MELEKDLALR VQEVAELRRR LESSKPPGDV DMSLSLLQEI SALQEKLEVT
560 570 580 590 600
HTDHQNEVTS LKDHFGTREE MFQKEIKALH AATEKLSKEN ESLRSKLDHA
610 620 630 640 650
NKENSDVIAL WKSKLETAIA SHQQAMEELK VSFSKGIGTD SAEFAELKTQ
660 670 680 690 700
IERLRLDYQH EIESLQSKQD SERSAHAKEM ESMKAKLMKI IKEKEDSLEA
710 720 730 740 750
VKARLDTAED QHLVEMEEML SKLQEAEIKK EKFASASEEA VSTQTSMQDT
760 770 780 790 800
VNKLHQKEEQ FNMLSSELEK LRENLTDMEA KFKEKDERED QLVKAKEKLE
810 820 830 840 850
NDIAEIMKMS GDNSSQLTKM NDELRLKERS VEELQLKLTK ANENASLLQK
860 870 880 890 900
SIGEVTLKAE QSQQEAAKKH EEEKKELENK LLELEKKMET SHYQCQDLKA
910 920 930 940 950
KYEKASSETK IKHEEILQNF QKMLVDTEDK LKAAQEANRD LMQDMEELKS
960 970 980 990 1000
QADKAKAAQT AEDAMQIMEQ MTKEKTETLA SLEDTKQTNA KLQSELDTLK
1010 1020 1030 1040 1050
ENNLKTVEEL NKSKELLNEE NQKMEEFKKE IETLKQAAAQ KSQQLSALQE
1060 1070 1080 1090 1100
ENVKLAEELG RTRDEVTSHQ KLEEERSVLN NQLLEMKKSL PSNTLRESEY
1110 1120 1130 1140 1150
RKDADEEKAS LQKSISLTSA LLTEKDAELE KLRNEVTVLR GENASAKSLH
1160 1170 1180 1190 1200
SVVQTLESDK VKLELKVKNL ELQLKENKRQ LSSSSGNTDV QTEEDERAQE
1210 1220 1230 1240 1250
SQQMIDFLNS VIVDLQRKNQ DLKMKVEMMS EAALNGNGED PNSYDSDDQE
1260 1270 1280 1290 1300
KQSKKKPRLF CDICDCFDLH DTEDCPTQAQ MSEDPPHSTH HGSRSEERPY
1310 1320
CEICEMFGHW ATNCNDDETF
Length:1,320
Mass (Da):148,279
Last modified:November 30, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81D8096405D4689D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K681A0A0G2K681_RAT
CAP-Gly domain-containing linker pr...
Clip1
1,416Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1MAH8F1MAH8_RAT
CAP-Gly domain-containing linker pr...
Clip1
1,319Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JTX8A0A0G2JTX8_RAT
CAP-Gly domain-containing linker pr...
Clip1
340Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1232A → G in CAB92974 (PubMed:11290329).1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ237670 mRNA Translation: CAB92974.1
AC117299 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_113933.2, NM_031745.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000078530; ENSRNOP00000072766; ENSRNOG00000001247

Database of genes from NCBI RefSeq genomes

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GeneIDi
65201

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:65201

UCSC genome browser

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UCSCi
RGD:67404 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237670 mRNA Translation: CAB92974.1
AC117299 Genomic DNA No translation available.
RefSeqiNP_113933.2, NM_031745.2

3D structure databases

SMRiQ9JK25
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9JK25, 9 interactors
MINTiQ9JK25
STRINGi10116.ENSRNOP00000001685

PTM databases

iPTMnetiQ9JK25
PhosphoSitePlusiQ9JK25

Proteomic databases

jPOSTiQ9JK25
PRIDEiQ9JK25

Genome annotation databases

EnsembliENSRNOT00000078530; ENSRNOP00000072766; ENSRNOG00000001247
GeneIDi65201
KEGGirno:65201
UCSCiRGD:67404 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6249
RGDi67404 Clip1

Phylogenomic databases

eggNOGiKOG4568 Eukaryota
COG5244 LUCA
GeneTreeiENSGT00940000155122
KOiK10421
OrthoDBi1110101at2759
PhylomeDBiQ9JK25

Enzyme and pathway databases

ReactomeiR-RNO-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-RNO-2467813 Separation of Sister Chromatids
R-RNO-2500257 Resolution of Sister Chromatid Cohesion
R-RNO-5626467 RHO GTPases activate IQGAPs
R-RNO-5663220 RHO GTPases Activate Formins
R-RNO-68877 Mitotic Prometaphase
R-RNO-9648025 EML4 and NUDC in mitotic spindle formation

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9JK25

Gene expression databases

BgeeiENSRNOG00000001247 Expressed in skeletal muscle tissue and 8 other tissues
ExpressionAtlasiQ9JK25 baseline and differential
GenevisibleiQ9JK25 RN

Family and domain databases

Gene3Di2.30.30.190, 2 hits
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR032108 CLIP1_ZNF
PfamiView protein in Pfam
PF01302 CAP_GLY, 2 hits
PF16641 CLIP1_ZNF, 2 hits
SMARTiView protein in SMART
SM01052 CAP_GLY, 2 hits
SUPFAMiSSF74924 SSF74924, 2 hits
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 2 hits
PS50245 CAP_GLY_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLIP1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JK25
Secondary accession number(s): A0A0G2K3T3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2016
Last sequence update: November 30, 2016
Last modified: April 22, 2020
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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