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Protein

Proteasome assembly chaperone 1

Gene

Psmg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity).By similarity

GO - Molecular functioni

  • proteasome binding Source: MGI

GO - Biological processi

  • cerebellar granule cell precursor proliferation Source: MGI
  • proteasome assembly Source: UniProtKB
  • proteasome core complex assembly Source: MGI

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome assembly chaperone 1
Alternative name(s):
Down syndrome critical region protein 2 homolog
Gene namesi
Name:Psmg1Imported
Synonyms:Dscr2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1860263 Psmg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003225472 – 289Proteasome assembly chaperone 1Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei18PhosphothreonineBy similarity1
Modified residuei55PhosphothreonineBy similarity1
Modified residuei181PhosphoserineBy similarity1
Modified residuei265N6-acetyllysineBy similarity1

Post-translational modificationi

Degraded by the proteasome upon completion of 20S proteasome maturation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9JK23
MaxQBiQ9JK23
PaxDbiQ9JK23
PeptideAtlasiQ9JK23
PRIDEiQ9JK23

PTM databases

iPTMnetiQ9JK23
PhosphoSitePlusiQ9JK23
SwissPalmiQ9JK23

Expressioni

Tissue specificityi

Highly expressed in testis with moderate expression in brain, liver and kidney and low levels in heart, skeletal muscle and pancreas.1 Publication

Developmental stagei

Expressed at a fairly constant level throughout embryonic development.1 Publication

Gene expression databases

BgeeiENSMUSG00000022913 Expressed in 308 organ(s), highest expression level in otic placode
ExpressionAtlasiQ9JK23 baseline and differential
GenevisibleiQ9JK23 MM

Interactioni

Subunit structurei

Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9JK23, 1 interactor
MINTiQ9JK23
STRINGi10090.ENSMUSP00000023630

Structurei

3D structure databases

ProteinModelPortaliQ9JK23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PSMG1 family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IGRN Eukaryota
ENOG4111EZT LUCA
GeneTreeiENSGT00500000044950
HOGENOMiHOG000072680
HOVERGENiHBG051410
InParanoidiQ9JK23
KOiK11875
OMAiFLCQCSC
OrthoDBiEOG091G19W8
PhylomeDBiQ9JK23
TreeFamiTF331909

Family and domain databases

InterProiView protein in InterPro
IPR016565 Proteasome_assmbl_chp_1
PANTHERiPTHR15069 PTHR15069, 1 hit
PfamiView protein in Pfam
PF16094 PAC1, 1 hit
PIRSFiPIRSF010076 Psome_chaperone-1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JK23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATFFGEVV KAPCRAGTEE EEEEEEQSRR DTPEDREVRR QLARKREVRL
60 70 80 90 100
LRRQTETSLE AVLLETHPCS KFIIAVGSNA TAFLSAFVMN SGVWEEVGCA
110 120 130 140 150
KLWNEWCRTT DTVRLSPTDV FCVFYQLKSD PSVFLCQCSC YIAEDQQFQW
160 170 180 190 200
LEKVFGFQPR KSMQVTVLTC RHITDYKTPE STCSLSSPFL RALKTQTFKD
210 220 230 240 250
ALCCPLLEQP NIVHDLSAAV LSYCQVWKIP AVLYLCYTDV MKLDRVTVEA
260 270 280
FKPLLSSRSL KCLVKNIPES TEILKKLMTT NEIQSNIYT
Length:289
Mass (Da):33,104
Last modified:October 1, 2000 - v1
Checksum:iFEB4F7FDDC020F06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39R → A in BAC40157 (PubMed:16141072).Curated1
Sequence conflicti229I → T in BAC40157 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238270 mRNA Translation: CAB87195.1
AK042203 mRNA Translation: BAC31197.1
AK088118 mRNA Translation: BAC40157.1
BC032965 mRNA Translation: AAH32965.1
BC060285 mRNA Translation: AAH60285.1
CCDSiCCDS28352.1
PIRiJC7279
RefSeqiNP_062410.1, NM_019537.3
UniGeneiMm.396248

Genome annotation databases

EnsembliENSMUST00000023630; ENSMUSP00000023630; ENSMUSG00000022913
GeneIDi56088
KEGGimmu:56088
UCSCiuc008ach.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238270 mRNA Translation: CAB87195.1
AK042203 mRNA Translation: BAC31197.1
AK088118 mRNA Translation: BAC40157.1
BC032965 mRNA Translation: AAH32965.1
BC060285 mRNA Translation: AAH60285.1
CCDSiCCDS28352.1
PIRiJC7279
RefSeqiNP_062410.1, NM_019537.3
UniGeneiMm.396248

3D structure databases

ProteinModelPortaliQ9JK23
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JK23, 1 interactor
MINTiQ9JK23
STRINGi10090.ENSMUSP00000023630

PTM databases

iPTMnetiQ9JK23
PhosphoSitePlusiQ9JK23
SwissPalmiQ9JK23

Proteomic databases

EPDiQ9JK23
MaxQBiQ9JK23
PaxDbiQ9JK23
PeptideAtlasiQ9JK23
PRIDEiQ9JK23

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023630; ENSMUSP00000023630; ENSMUSG00000022913
GeneIDi56088
KEGGimmu:56088
UCSCiuc008ach.1 mouse

Organism-specific databases

CTDi8624
MGIiMGI:1860263 Psmg1

Phylogenomic databases

eggNOGiENOG410IGRN Eukaryota
ENOG4111EZT LUCA
GeneTreeiENSGT00500000044950
HOGENOMiHOG000072680
HOVERGENiHBG051410
InParanoidiQ9JK23
KOiK11875
OMAiFLCQCSC
OrthoDBiEOG091G19W8
PhylomeDBiQ9JK23
TreeFamiTF331909

Miscellaneous databases

PROiPR:Q9JK23
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022913 Expressed in 308 organ(s), highest expression level in otic placode
ExpressionAtlasiQ9JK23 baseline and differential
GenevisibleiQ9JK23 MM

Family and domain databases

InterProiView protein in InterPro
IPR016565 Proteasome_assmbl_chp_1
PANTHERiPTHR15069 PTHR15069, 1 hit
PfamiView protein in Pfam
PF16094 PAC1, 1 hit
PIRSFiPIRSF010076 Psome_chaperone-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSMG1_MOUSE
AccessioniPrimary (citable) accession number: Q9JK23
Secondary accession number(s): Q8BU12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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