UniProtKB - Q9JJZ6 (KLF13_MOUSE)

BLAST

>sp|Q9JJZ6|KLF13_MOUSE Krueppel-like factor 13 OS=Mus musculus OX=10090 GN=Klf13 PE=1 SV=2
MAAAAYVDHFAAECLVSMSSRAVVHEPREGPEPRPEGAAAAAPTLPRVDERRDGKDSASL
FVVARILADLNQQAPAPAPAERREGAAARKARTPCRLPPAPPAPPPGPEPASPGQAGAPA
APPSPAWSEPEAALEQEPGPAGSGEPGLRQRGRRGRSRADLESPQRKHKCHYAGCEKVYG
KSSHLKAHLRTHTGERPFACSWQECNKKFARSDELARHYRTHTGEKKFSCPICEKRFMRS
DHLTKHARRHANFHPGMLQRRGGGSRTGSLSDYSRSDASSPTISPASSP

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History
Entry version 141 (07 Nov 2018)
Sequence version 2 (02 Nov 2001)
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Protein

Krueppel-like factor 13

Gene

Klf13

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	168 – 192	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	198 – 222	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	228 – 250	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 10642511
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 10642511
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10642511

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18285334
negative regulation of erythrocyte differentiation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18285334
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 10642511
regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 10642511
transcription by RNA polymerase II
Source: MGI
Inferred from sequence or structural similarityⁱ
- 11087666

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Krueppel-like factor 13 Alternative name(s): Basic transcription element-binding protein 3 Short name: BTE-binding protein 3 Erythroid transcription factor FKLF-2 RANTES factor of late activated T-lymphocytes 1 Short name: RFLAT-1 Transcription factor BTEB3
Gene namesⁱ	Name:Klf13 Synonyms:Bteb3, Fklf2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1354948 Klf13

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047185	1 – 289	Krueppel-like factor 13Add BLAST		289

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	269	PhosphoserineBy similarity	1
Modified residueⁱ	271	PhosphoserineBy similarity	1
Modified residueⁱ	280	PhosphoserineCombined sources	1
Modified residueⁱ	284	PhosphoserineCombined sources	1
Modified residueⁱ	288	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9JJZ6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9JJZ6
PaxDbⁱ	Q9JJZ6
PeptideAtlas More...PeptideAtlasⁱ	Q9JJZ6
PRIDEⁱ	Q9JJZ6

PTM databases

iPTMnetⁱ	Q9JJZ6
PhosphoSitePlusⁱ	Q9JJZ6

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSMUSG00000052040 Expressed in 313 organ(s), highest expression level in rostral migratory stream
CleanExⁱ	MM_KLF13
ExpressionAtlasⁱ	Q9JJZ6 baseline and differential
Genevisibleⁱ	Q9JJZ6 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	206125, 2 interactors
IntActⁱ	Q9JJZ6, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q9JJZ6
STRINGⁱ	10090.ENSMUSP00000067680

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9JJZ6
SMRⁱ	Q9JJZ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	2 – 146	Ala/Pro-richAdd BLAST	145
Compositional biasⁱ	149 – 169	Arg/Lys-rich (basic)Add BLAST	21
Compositional biasⁱ	265 – 288	Ser-richAdd BLAST	24

Sequence similaritiesⁱ

Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	168 – 192	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	198 – 222	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	228 – 250	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000233575
HOVERGENⁱ	HBG050746
InParanoidⁱ	Q9JJZ6
KEGG Orthology (KO) More...KOⁱ	K09208
OMAⁱ	FNQQTPN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1BN0
PhylomeDBⁱ	Q9JJZ6
TreeFamⁱ	TF351003

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9JJZ6-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAAAAYVDHF AAECLVSMSS RAVVHEPREG PEPRPEGAAA AAPTLPRVDE 
        60         70         80         90        100
RRDGKDSASL FVVARILADL NQQAPAPAPA ERREGAAARK ARTPCRLPPA 
       110        120        130        140        150
PPAPPPGPEP ASPGQAGAPA APPSPAWSEP EAALEQEPGP AGSGEPGLRQ 
       160        170        180        190        200
RGRRGRSRAD LESPQRKHKC HYAGCEKVYG KSSHLKAHLR THTGERPFAC 
       210        220        230        240        250
SWQECNKKFA RSDELARHYR THTGEKKFSC PICEKRFMRS DHLTKHARRH 
       260        270        280 
ANFHPGMLQR RGGGSRTGSL SDYSRSDASS PTISPASSP

Length:289

Mass (Da):31,136

Last modified:November 2, 2001 - v2

Checksum:ⁱE248EF12890DA090

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

V9GX95	V9GX95_MOUSE	Krueppel-like factor 13 Krueppel-like factor 13	Klf13	82	Annotation score:
A0A087WQX4	A0A087WQX4_MOUSE	Krueppel-like factor 13 Krueppel-like factor 13	Klf13	52	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	13 – 30	ECLVS…EPREG → SASCPCQPRSRARAAGR in CAC06697 (PubMed:11087666).CuratedAdd BLAST	18
Sequence conflictⁱ	32	E → R in CAB75887 (PubMed:10642511).Curated	1
Sequence conflictⁱ	43	P → L in CAB75887 (PubMed:10642511).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ245644 mRNA Translation: CAB75887.1 AF251796 mRNA Translation: AAF73964.1 AJ275987 mRNA Translation: CAC06697.1 AF252285 mRNA Translation: AAF65826.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21331.1
NCBI Reference Sequences More...RefSeqⁱ	NP_067341.2, NM_021366.3
UniGeneⁱ	Mm.240473

Genome annotation databases

Ensemblⁱ	ENSMUST00000063694; ENSMUSP00000067680; ENSMUSG00000052040
GeneIDⁱ	50794
KEGGⁱ	mmu:50794
UCSC genome browser More...UCSCⁱ	uc009hfn.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9JJZ6	C2-H2 zinc finger protein (Fragment)		MOUSE		66	UniRef100_Q9JJZ6

Protein	Similar proteins		Species	Score	Length	Source
Q9JJZ6	Krueppel-like factor 13		HUMAN		288	UniRef90_Q9JJZ6
C2-H2 zinc finger protein (Fragment)		MOUSE		66
KLF13 protein		BOVIN		296
Krueppel-like factor 13		ODORO		293
Kruppel-like factor 13 (Fragment)		MUSPF		94
+49

Protein	Similar proteins		Species	Score	Length	Source
Q9JJZ6	Krueppel-like factor 13		HUMAN		288	UniRef50_Q9JJZ6
C2-H2 zinc finger protein (Fragment)		MOUSE		66
KLF13 protein		BOVIN		296
Uncharacterized protein		FELCA		293
Krueppel-like factor 13		NEOSC		293
+158

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ245644 mRNA Translation: CAB75887.1 AF251796 mRNA Translation: AAF73964.1 AJ275987 mRNA Translation: CAC06697.1 AF252285 mRNA Translation: AAF65826.1
CCDSⁱ	CCDS21331.1
RefSeqⁱ	NP_067341.2, NM_021366.3
UniGeneⁱ	Mm.240473

3D structure databases

ProteinModelPortalⁱ	Q9JJZ6
SMRⁱ	Q9JJZ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	206125, 2 interactors
IntActⁱ	Q9JJZ6, 1 interactor
MINTⁱ	Q9JJZ6
STRINGⁱ	10090.ENSMUSP00000067680

PTM databases

iPTMnetⁱ	Q9JJZ6
PhosphoSitePlusⁱ	Q9JJZ6

Proteomic databases

EPDⁱ	Q9JJZ6
MaxQBⁱ	Q9JJZ6
PaxDbⁱ	Q9JJZ6
PeptideAtlasⁱ	Q9JJZ6
PRIDEⁱ	Q9JJZ6

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	50794
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000063694; ENSMUSP00000067680; ENSMUSG00000052040
GeneIDⁱ	50794
KEGGⁱ	mmu:50794
UCSCⁱ	uc009hfn.2 mouse

Organism-specific databases

CTDⁱ	51621
MGIⁱ	MGI:1354948 Klf13

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000233575
HOVERGENⁱ	HBG050746
InParanoidⁱ	Q9JJZ6
KOⁱ	K09208
OMAⁱ	FNQQTPN
OrthoDBⁱ	EOG091G1BN0
PhylomeDBⁱ	Q9JJZ6
TreeFamⁱ	TF351003

Miscellaneous databases

ChiTaRSⁱ	Klf13 mouse
Protein Ontology More...PROⁱ	PR:Q9JJZ6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000052040 Expressed in 313 organ(s), highest expression level in rostral migratory stream
CleanExⁱ	MM_KLF13
ExpressionAtlasⁱ	Q9JJZ6 baseline and differential
Genevisibleⁱ	Q9JJZ6 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KLF13_MOUSE
Accessionⁱ	Q9JJZ6Primary (citable) accession number: Q9JJZ6 Secondary accession number(s): Q9ESX3, Q9JHF8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
	Last sequence update:	November 2, 2001
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9JJZ6 (KLF13_MOUSE)

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Krueppel-like factor 13

Klf13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ