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UniProtKB - Q9JJZ6 (KLF13_MOUSE)
Protein
Krueppel-like factor 13
Gene
Klf13
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 168 – 192 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 198 – 222 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 228 – 250 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of erythrocyte differentiation Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
- transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Krueppel-like factor 13Alternative name(s): Basic transcription element-binding protein 3 Short name: BTE-binding protein 3 Erythroid transcription factor FKLF-2 RANTES factor of late activated T-lymphocytes 1 Short name: RFLAT-1 Transcription factor BTEB3 |
Gene namesi | Name:Klf13 Synonyms:Bteb3, Fklf2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1354948, Klf13 |
VEuPathDBi | HostDB:ENSMUSG00000052040 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047185 | 1 – 289 | Krueppel-like factor 13Add BLAST | 289 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 269 | PhosphoserineBy similarity | 1 | |
Modified residuei | 271 | PhosphoserineBy similarity | 1 | |
Modified residuei | 280 | PhosphoserineCombined sources | 1 | |
Modified residuei | 284 | PhosphoserineCombined sources | 1 | |
Modified residuei | 288 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9JJZ6 |
jPOSTi | Q9JJZ6 |
MaxQBi | Q9JJZ6 |
PaxDbi | Q9JJZ6 |
PeptideAtlasi | Q9JJZ6 |
PRIDEi | Q9JJZ6 |
ProteomicsDBi | 264767 |
PTM databases
iPTMneti | Q9JJZ6 |
PhosphoSitePlusi | Q9JJZ6 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSMUSG00000052040, Expressed in rostral migratory stream and 334 other tissues |
Genevisiblei | Q9JJZ6, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 206125, 3 interactors |
IntActi | Q9JJZ6, 1 interactor |
MINTi | Q9JJZ6 |
STRINGi | 10090.ENSMUSP00000067680 |
Miscellaneous databases
RNActi | Q9JJZ6, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 54 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 70 – 168 | DisorderedSequence analysisAdd BLAST | 99 | |
Regioni | 250 – 289 | DisorderedSequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 95 – 126 | Pro residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 149 – 168 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 264 – 289 | Polar residuesSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 168 – 192 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 198 – 222 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 228 – 250 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161911 |
HOGENOMi | CLU_002678_33_2_1 |
InParanoidi | Q9JJZ6 |
OMAi | WQGCNKK |
OrthoDBi | 1308225at2759 |
PhylomeDBi | Q9JJZ6 |
TreeFami | TF351003 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9JJZ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAAYVDHF AAECLVSMSS RAVVHEPREG PEPRPEGAAA AAPTLPRVDE
60 70 80 90 100
RRDGKDSASL FVVARILADL NQQAPAPAPA ERREGAAARK ARTPCRLPPA
110 120 130 140 150
PPAPPPGPEP ASPGQAGAPA APPSPAWSEP EAALEQEPGP AGSGEPGLRQ
160 170 180 190 200
RGRRGRSRAD LESPQRKHKC HYAGCEKVYG KSSHLKAHLR THTGERPFAC
210 220 230 240 250
SWQECNKKFA RSDELARHYR THTGEKKFSC PICEKRFMRS DHLTKHARRH
260 270 280
ANFHPGMLQR RGGGSRTGSL SDYSRSDASS PTISPASSP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WQX4 | A0A087WQX4_MOUSE | Krueppel-like factor 13 | Klf13 | 52 | Annotation score: | ||
V9GX95 | V9GX95_MOUSE | Krueppel-like factor 13 | Klf13 | 82 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 – 30 | ECLVS…EPREG → SASCPCQPRSRARAAGR in CAC06697 (PubMed:11087666).CuratedAdd BLAST | 18 | |
Sequence conflicti | 32 | E → R in CAB75887 (PubMed:10642511).Curated | 1 | |
Sequence conflicti | 43 | P → L in CAB75887 (PubMed:10642511).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ245644 mRNA Translation: CAB75887.1 AF251796 mRNA Translation: AAF73964.1 AJ275987 mRNA Translation: CAC06697.1 AF252285 mRNA Translation: AAF65826.1 |
CCDSi | CCDS21331.1 |
RefSeqi | NP_067341.2, NM_021366.3 |
Genome annotation databases
Ensembli | ENSMUST00000063694; ENSMUSP00000067680; ENSMUSG00000052040 |
GeneIDi | 50794 |
KEGGi | mmu:50794 |
UCSCi | uc009hfn.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ245644 mRNA Translation: CAB75887.1 AF251796 mRNA Translation: AAF73964.1 AJ275987 mRNA Translation: CAC06697.1 AF252285 mRNA Translation: AAF65826.1 |
CCDSi | CCDS21331.1 |
RefSeqi | NP_067341.2, NM_021366.3 |
3D structure databases
SMRi | Q9JJZ6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 206125, 3 interactors |
IntActi | Q9JJZ6, 1 interactor |
MINTi | Q9JJZ6 |
STRINGi | 10090.ENSMUSP00000067680 |
PTM databases
iPTMneti | Q9JJZ6 |
PhosphoSitePlusi | Q9JJZ6 |
Proteomic databases
EPDi | Q9JJZ6 |
jPOSTi | Q9JJZ6 |
MaxQBi | Q9JJZ6 |
PaxDbi | Q9JJZ6 |
PeptideAtlasi | Q9JJZ6 |
PRIDEi | Q9JJZ6 |
ProteomicsDBi | 264767 |
Protocols and materials databases
Antibodypediai | 9456, 183 antibodies from 32 providers |
DNASUi | 50794 |
Genome annotation databases
Ensembli | ENSMUST00000063694; ENSMUSP00000067680; ENSMUSG00000052040 |
GeneIDi | 50794 |
KEGGi | mmu:50794 |
UCSCi | uc009hfn.2, mouse |
Organism-specific databases
CTDi | 51621 |
MGIi | MGI:1354948, Klf13 |
VEuPathDBi | HostDB:ENSMUSG00000052040 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161911 |
HOGENOMi | CLU_002678_33_2_1 |
InParanoidi | Q9JJZ6 |
OMAi | WQGCNKK |
OrthoDBi | 1308225at2759 |
PhylomeDBi | Q9JJZ6 |
TreeFami | TF351003 |
Miscellaneous databases
BioGRID-ORCSi | 50794, 3 hits in 65 CRISPR screens |
ChiTaRSi | Klf13, mouse |
PROi | PR:Q9JJZ6 |
RNActi | Q9JJZ6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000052040, Expressed in rostral migratory stream and 334 other tissues |
Genevisiblei | Q9JJZ6, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KLF13_MOUSE | |
Accessioni | Q9JJZ6Primary (citable) accession number: Q9JJZ6 Secondary accession number(s): Q9ESX3, Q9JHF8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 2, 2001 |
Last sequence update: | November 2, 2001 | |
Last modified: | February 23, 2022 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families