UniProtKB - Q9JJW3 (ATPMK_RAT)
ATP synthase membrane subunit K, mitochondrial
Atp5mk
Functioni
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. ATP5MK is a minor subunit of the mitochondrial membrane ATP synthase required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria.
By similarityNames & Taxonomyi
Protein namesi | Recommended name: ATP synthase membrane subunit K, mitochondrialAlternative name(s): ATP synthase membrane subunit DAPIT, mitochondrialCurated Diabetes-associated protein in insulin-sensitive tissues Up-regulated during skeletal muscle growth protein 5Curated |
Gene namesi | Name:Atp5mk Synonyms:Atp5mdImported, Dapit, Usmg5 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
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Organism-specific databases
RGDi | 631426, Atp5md |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane By similarity; Single-pass membrane protein Sequence analysis
Mitochondrion
- mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
- mitochondrion Source: RGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 23 – 45 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Membrane, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000231580 | 1 – 58 | ATP synthase membrane subunit K, mitochondrialAdd BLAST | 58 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 16 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 17 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | Q9JJW3 |
PRIDEi | Q9JJW3 |
PTM databases
iPTMneti | Q9JJW3 |
PhosphoSitePlusi | Q9JJW3 |
SwissPalmi | Q9JJW3 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000020296, Expressed in lung and 10 other tissues |
Interactioni
Subunit structurei
Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). The ATP synthase complex/complex V exists as a monomeric and a dimeric supercomplex that helps shape mitochondrial cristae to optimize proton flow.
By similarityProtein-protein interaction databases
BioGRIDi | 251083, 1 interactor |
IntActi | Q9JJW3, 1 interactor |
MINTi | Q9JJW3 |
STRINGi | 10116.ENSRNOP00000027496 |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S82X, Eukaryota |
GeneTreei | ENSGT00390000015489 |
HOGENOMi | CLU_209345_1_0_1 |
InParanoidi | Q9JJW3 |
OMAi | GIAKHFN |
OrthoDBi | 1629213at2759 |
PhylomeDBi | Q9JJW3 |
TreeFami | TF324671 |
Family and domain databases
InterProi | View protein in InterPro IPR009125, ATPMK |
PANTHERi | PTHR34038, PTHR34038, 1 hit |
Pfami | View protein in Pfam PF14960, ATP_synth_reg, 1 hit |
PRINTSi | PR01821, DAPIT |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAGPESDGQF QFTGIKKYFN SYTLTGRMNC VLATYGGIAL LVLYFKLRPK
KTPAVKAT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ271158 mRNA Translation: CAB71156.1 |
RefSeqi | NP_598228.1, NM_133544.1 XP_008766441.1, XM_008768219.2 XP_008773622.1, XM_008775400.2 |
Genome annotation databases
Ensembli | ENSRNOT00000027496; ENSRNOP00000027496; ENSRNOG00000020296 ENSRNOT00000100748; ENSRNOP00000093868; ENSRNOG00000067471 |
GeneIDi | 103693430 171069 |
KEGGi | rno:103693430 rno:171069 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ271158 mRNA Translation: CAB71156.1 |
RefSeqi | NP_598228.1, NM_133544.1 XP_008766441.1, XM_008768219.2 XP_008773622.1, XM_008775400.2 |
3D structure databases
AlphaFoldDBi | Q9JJW3 |
SMRi | Q9JJW3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 251083, 1 interactor |
IntActi | Q9JJW3, 1 interactor |
MINTi | Q9JJW3 |
STRINGi | 10116.ENSRNOP00000027496 |
PTM databases
iPTMneti | Q9JJW3 |
PhosphoSitePlusi | Q9JJW3 |
SwissPalmi | Q9JJW3 |
Proteomic databases
PaxDbi | Q9JJW3 |
PRIDEi | Q9JJW3 |
Genome annotation databases
Ensembli | ENSRNOT00000027496; ENSRNOP00000027496; ENSRNOG00000020296 ENSRNOT00000100748; ENSRNOP00000093868; ENSRNOG00000067471 |
GeneIDi | 103693430 171069 |
KEGGi | rno:103693430 rno:171069 |
Organism-specific databases
CTDi | 84833 |
RGDi | 631426, Atp5md |
Phylogenomic databases
eggNOGi | ENOG502S82X, Eukaryota |
GeneTreei | ENSGT00390000015489 |
HOGENOMi | CLU_209345_1_0_1 |
InParanoidi | Q9JJW3 |
OMAi | GIAKHFN |
OrthoDBi | 1629213at2759 |
PhylomeDBi | Q9JJW3 |
TreeFami | TF324671 |
Miscellaneous databases
PROi | PR:Q9JJW3 |
Gene expression databases
Bgeei | ENSRNOG00000020296, Expressed in lung and 10 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR009125, ATPMK |
PANTHERi | PTHR34038, PTHR34038, 1 hit |
Pfami | View protein in Pfam PF14960, ATP_synth_reg, 1 hit |
PRINTSi | PR01821, DAPIT |
MobiDBi | Search... |
Entry informationi
Entry namei | ATPMK_RAT | |
Accessioni | Q9JJW3Primary (citable) accession number: Q9JJW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |