Sodium channel protein type 5 subunit alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ankyrin binding Source: MGI
• calmodulin binding Source: MGI
• cation channel activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• enzyme binding Source: MGI
• fibroblast growth factor binding Source: MGI
• ion channel binding Source: MGI
• nitric-oxide synthase binding Source: MGI
• protein domain specific binding Source: MGI
• protein kinase binding Source: MGI
• scaffold protein binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex."
    Ueda K., Valdivia C., Medeiros-Domingo A., Tester D.J., Vatta M., Farrugia G., Ackerman M.J., Makielski J.C.
    Proc. Natl. Acad. Sci. U.S.A. 105:9355-9360(2008) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: MGI
• voltage-gated ion channel activity Source: UniProtKB-KW
• voltage-gated sodium channel activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants."
    Zimmer T., Bollensdorff C., Haufe V., Birch-Hirschfeld E., Benndorf K.
    Am. J. Physiol. 282:H1007-H1017(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
• voltage-gated sodium channel activity involved in AV node cell action potential Source: MGI
• voltage-gated sodium channel activity involved in bundle of His cell action potential Source: MGI
• voltage-gated sodium channel activity involved in cardiac muscle cell action potential Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a."
    Papadatos G.A., Wallerstein P.M., Head C.E., Ratcliff R., Brady P.A., Benndorf K., Saumarez R.C., Trezise A.E., Huang C.L., Vandenberg J.I., Colledge W.H., Grace A.A.
    Proc Natl Acad Sci U S A 99:6210-6215(2002) [PubMed] [Europe PMC] [Abstract]
  • "Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy."
    Misra C., Bangru S., Lin F., Lam K., Koenig S.N., Lubbers E.R., Hedhli J., Murphy N.P., Parker D.J., Dobrucki L.W., Cooper T.A., Tajkhorshid E., Mohler P.J., Kalsotra A.
    Dev Cell 52:748-763.e6(2020) [PubMed] [Europe PMC] [Abstract]
• voltage-gated sodium channel activity involved in Purkinje myocyte action potential Source: MGI
• voltage-gated sodium channel activity involved in SA node cell action potential Source: MGIInferred from mutant phenotypeⁱ
  • "Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a."
    Lei M., Goddard C., Liu J., Leoni A.L., Royer A., Fung S.S., Xiao G., Ma A., Zhang H., Charpentier F., Vandenberg J.I., Colledge W.H., Grace A.A., Huang C.L.
    J Physiol 567:387-400(2005) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• atrial cardiac muscle cell action potential Source: MGI
• AV node cell action potential Source: MGI
• AV node cell to bundle of His cell communication Source: MGI
• bundle of His cell action potential Source: MGI
• cardiac muscle cell action potential involved in contraction Source: MGIInferred from mutant phenotypeⁱ
  • "Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy."
    Misra C., Bangru S., Lin F., Lam K., Koenig S.N., Lubbers E.R., Hedhli J., Murphy N.P., Parker D.J., Dobrucki L.W., Cooper T.A., Tajkhorshid E., Mohler P.J., Kalsotra A.
    Dev Cell 52:748-763.e6(2020) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle contraction Source: MGI
• cardiac ventricle development Source: MGIInferred from mutant phenotypeⁱ
  • "Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a."
    Papadatos G.A., Wallerstein P.M., Head C.E., Ratcliff R., Brady P.A., Benndorf K., Saumarez R.C., Trezise A.E., Huang C.L., Vandenberg J.I., Colledge W.H., Grace A.A.
    Proc Natl Acad Sci U S A 99:6210-6215(2002) [PubMed] [Europe PMC] [Abstract]
• cell communication involved in cardiac conduction Source: MGIInferred from mutant phenotypeⁱ
  • "Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy."
    Misra C., Bangru S., Lin F., Lam K., Koenig S.N., Lubbers E.R., Hedhli J., Murphy N.P., Parker D.J., Dobrucki L.W., Cooper T.A., Tajkhorshid E., Mohler P.J., Kalsotra A.
    Dev Cell 52:748-763.e6(2020) [PubMed] [Europe PMC] [Abstract]
• cellular response to calcium ion Source: UniProtKB
• membrane depolarization Source: MGI
• membrane depolarization during action potential Source: MGI
• membrane depolarization during atrial cardiac muscle cell action potential Source: MGI
• membrane depolarization during AV node cell action potential Source: MGI
• membrane depolarization during bundle of His cell action potential Source: MGI
• membrane depolarization during cardiac muscle cell action potential Source: MGI
• membrane depolarization during Purkinje myocyte cell action potential Source: MGI
• membrane depolarization during SA node cell action potential Source: MGI
• neuronal action potential Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of action potential Source: MGI
• positive regulation of epithelial cell proliferation Source: MGI
• positive regulation of heart rate Source: MGI
• positive regulation of sodium ion transport Source: MGI
• regulation of atrial cardiac muscle cell membrane depolarization Source: MGI
• regulation of atrial cardiac muscle cell membrane repolarization Source: MGI
• regulation of cardiac muscle cell contraction Source: MGIInferred from mutant phenotypeⁱ
  • "Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging."
    van Veen T.A., Stein M., Royer A., Le Quang K., Charpentier F., Colledge W.H., Huang C.L., Wilders R., Grace A.A., Escande D., de Bakker J.M., van Rijen H.V.
    Circulation 112:1927-1935(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of heart rate Source: MGI
• regulation of heart rate by cardiac conduction Source: MGIInferred from mutant phenotypeⁱ
  • "Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a."
    Papadatos G.A., Wallerstein P.M., Head C.E., Ratcliff R., Brady P.A., Benndorf K., Saumarez R.C., Trezise A.E., Huang C.L., Vandenberg J.I., Colledge W.H., Grace A.A.
    Proc Natl Acad Sci U S A 99:6210-6215(2002) [PubMed] [Europe PMC] [Abstract]
  • "Mouse model of SCN5A-linked hereditary Lenegre's disease: age-related conduction slowing and myocardial fibrosis."
    Royer A., van Veen T.A., Le Bouter S., Marionneau C., Griol-Charhbili V., Leoni A.L., Steenman M., van Rijen H.V., Demolombe S., Goddard C.A., Richer C., Escoubet B., Jarry-Guichard T., Colledge W.H., Gros D., de Bakker J.M., Grace A.A., Escande D., Charpentier F.
    Circulation 111:1738-1746(2005) [PubMed] [Europe PMC] [Abstract]
  • "Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a."
    Lei M., Goddard C., Liu J., Leoni A.L., Royer A., Fung S.S., Xiao G., Ma A., Zhang H., Charpentier F., Vandenberg J.I., Colledge W.H., Grace A.A., Huang C.L.
    J Physiol 567:387-400(2005) [PubMed] [Europe PMC] [Abstract]
  • "Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging."
    van Veen T.A., Stein M., Royer A., Le Quang K., Charpentier F., Colledge W.H., Huang C.L., Wilders R., Grace A.A., Escande D., de Bakker J.M., van Rijen H.V.
    Circulation 112:1927-1935(2005) [PubMed] [Europe PMC] [Abstract]
  • "Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy."
    Misra C., Bangru S., Lin F., Lam K., Koenig S.N., Lubbers E.R., Hedhli J., Murphy N.P., Parker D.J., Dobrucki L.W., Cooper T.A., Tajkhorshid E., Mohler P.J., Kalsotra A.
    Dev Cell 52:748-763.e6(2020) [PubMed] [Europe PMC] [Abstract]
• regulation of sodium ion transmembrane transport Source: MGI
• regulation of ventricular cardiac muscle cell membrane depolarization Source: MGI
• regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
• response to denervation involved in regulation of muscle adaptation Source: MGI
• response to organic cyclic compound Source: MGIInferred from mutant phenotypeⁱ
  • "Cardiac Na+ current regulation by pyridine nucleotides."
    Liu M., Sanyal S., Gao G., Gurung I.S., Zhu X., Gaconnet G., Kerchner L.J., Shang L.L., Huang C.L., Grace A., London B., Dudley S.C. Jr.
    Circ. Res. 105:737-745(2009) [PubMed] [Europe PMC] [Abstract]
• SA node cell action potential Source: MGI
• sodium ion import across plasma membrane Source: MGIInferred from mutant phenotypeⁱ
  • "Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy."
    Misra C., Bangru S., Lin F., Lam K., Koenig S.N., Lubbers E.R., Hedhli J., Murphy N.P., Parker D.J., Dobrucki L.W., Cooper T.A., Tajkhorshid E., Mohler P.J., Kalsotra A.
    Dev Cell 52:748-763.e6(2020) [PubMed] [Europe PMC] [Abstract]
• sodium ion transmembrane transport Source: MGI
• sodium ion transport Source: MGIInferred from direct assayⁱ
  • Ref.1

    "Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants."
    Zimmer T., Bollensdorff C., Haufe V., Birch-Hirschfeld E., Benndorf K.
    Am. J. Physiol. 282:H1007-H1017(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
• ventricular cardiac muscle cell action potential Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• ankyrin binding Source: MGI
• calmodulin binding Source: MGI
• enzyme binding Source: MGI
• fibroblast growth factor binding Source: MGI
• ion channel binding Source: MGI
• nitric-oxide synthase binding Source: MGI
• protein domain specific binding Source: MGI
• protein kinase binding Source: MGI
• scaffold protein binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex."
    Ueda K., Valdivia C., Medeiros-Domingo A., Tester D.J., Vatta M., Farrugia G., Ackerman M.J., Makielski J.C.
    Proc. Natl. Acad. Sci. U.S.A. 105:9355-9360(2008) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSATSQ ESREGLPEEE 
        60         70         80         90        100
APRPQLDLQA SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK 
       110        120        130        140        150
TIFRFSATNA LYVLSPFHPV RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ 
       160        170        180        190        200
HDPPPWTKYV EYTFTAIYTF ESLVKILARG FCLHAFTFLR DPWNWLDFSV 
       210        220        230        240        250
IVMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV GALIQSVKKL 
       260        270        280        290        300
ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTELNGT NGSVEADGIV 
       310        320        330        340        350
WNSLDVYLND PANYLLKNGT TDVLLCGNSS DAGTCPEGYR CLKAGENPDH 
       360        370        380        390        400
GYTSFDSFAW AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG 
       410        420        430        440        450
SFYLVNLILA VVAMAYEEQN QATIAETEEK EKRFQEAMEM LKKEHEALTI 
       460        470        480        490        500
RGVDTVSRSS LEMSPLAPVT NHERRSKRRK RLSSGTEDGG DDRLPKSDSE 
       510        520        530        540        550
DGPRALNQLS LTHGLSRTSM RPRSSRGSIF TFRRRDQGSE ADFADDENST 
       560        570        580        590        600
AGESESHRTS LLVPWPLRRP STQGQPGFGT SAPGHVLNGK RNSTVDCNGV 
       610        620        630        640        650
VSLLGAGDAE ATSPGSHLLR PIVLDRPPDT TTPSEEPGGP QMLTPQAPCA 
       660        670        680        690        700
DGFEEPGARQ RALSAVSVLT SALEELEESH RKCPPCWNRF AQHYLIWECC 
       710        720        730        740        750
PLWMSIKQKV KFVVMDPFAD LTITMCIVLN TLFMALEHYN MTAEFEEMLQ 
       760        770        780        790        800
VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG WNIFDSIIVI LSLMELGLSR 
       810        820        830        840        850
MGNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG NLTLVLAIIV 
       860        870        880        890        900
FIFAVVGMQL FGKNYSELRH RISDSGLLPR WHMMDFFHAF LIIFRILCGE 
       910        920        930        940        950
WIETMWDCME VSGQSLCLLV FLLVMVIGNL VVLNLFLALL LSSFSADNLT 
       960        970        980        990       1000
APDEDGEMNN LQLALARIQR GLRFVKRTTW DFCCGLLRRR PKKPAALATH 
      1010       1020       1030       1040       1050
SQLPSCIAAP RSPPPPEVEK APPARKETRF EEDKRPGQGT PGDTEPVCVP 
      1060       1070       1080       1090       1100
IAVAESDTDD QEEDEENSLG TEEEESSKQE SQVVSGGHEP PQEPRAWSQV 
      1110       1120       1130       1140       1150
SETTSSEAEA STSQADWQQE REAEPRAPGC GETPEDSYSE GSTADMTNTA 
      1160       1170       1180       1190       1200
DLLEQIPDLG EDVKDPEDCF TEGCVRRCPC CMVDTTQAPG KVWWRLRKTC 
      1210       1220       1230       1240       1250
YRIVEHSWFE TFIIFMILLS SGALAFEDIY LEERKTIKVL LEYADKMFTY 
      1260       1270       1280       1290       1300
VFVLEMLLKW VAYGFKKYFT NAWCWLDFLI VDVSLVSLVA NTLGFAEMGP 
      1310       1320       1330       1340       1350
IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF 
      1360       1370       1380       1390       1400
SIMGVNLFAG KFGRCINQTE GDLPLNYTIV NNKSECESFN VTGELYWTKV 
      1410       1420       1430       1440       1450
KVNFDNVGAG YLALLQVATF KGWMDIMYAA VDSRGYEEQP QWEDNLYMYI 
      1460       1470       1480       1490       1500
YFVVFIIFGS FFTLNLFIGV IIDNFNQQKK KLGGQDIFMT EEQKKYYNAM 
      1510       1520       1530       1540       1550
KKLGSKKPQK PIPRPLNKYQ GFIFDIVTKQ AFDVTIMFLI CLNMVTMMVE 
      1560       1570       1580       1590       1600
TDDQSPEKVN ILAKINLLFV AIFTGECIVK MAALRHYYFT NSWNIFDFVV 
      1610       1620       1630       1640       1650
VILSIVGTVL SDIIQKYFFS PTLFRVIRLA RIGRILRLIR GAKGIRTLLF 
      1660       1670       1680       1690       1700
ALMMSLPALF NIGLLLFLVM FIYSIFGMAN FAYVKWEAGI DDMFNFQTFA 
      1710       1720       1730       1740       1750
NSMLCLFQIT TSAGWDGLLS PILNTGPPYC DPNLPNSNGS RGNCGSPAVG 
      1760       1770       1780       1790       1800
ILFFTTYIII SFLIVVNMYI AIILENFSVA TEESTEPLSE DDFDMFYEIW 
      1810       1820       1830       1840       1850
EKFDPEATQF IEYLALSDFA DALSEPLRIA KPNQISLINM DLPMVSGDRI 
      1860       1870       1880       1890       1900
HCMDILFAFT KRVLGESGEM DALKIQMEEK FMAANPSKIS YEPITTTLRR 
      1910       1920       1930       1940       1950
KHEEVSATVI QRAFRRHLLQ RSVKHASFLF RQQAGSSGLS DEDAPEREGL 
      1960       1970       1980       1990       2000
IAYMMNENFS RRSGPLSSSS ISSTSFPPSY DSVTRATSDN LPVRASDYSR 
      2010 
SEDLADFPPS PDRDRESIV                                   

        10         20         30         40         50
MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSATSQ ESREGLPEEE 
        60         70         80         90        100
APRPQLDLQA SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK 
       110        120        130        140        150
TIFRFSATNA LYVLSPFHPV RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ 
       160        170        180        190        200
HDPPPWTKYV EYTFTAIYTF ESLVKILARG FCLHAFTFLR DPWNWLDFSV 
       210        220        230        240        250
IVMAYVSENI KLGNVSALRT FRVLRALKTI SVISGLKTIV GALIQSVKKL 
       260        270        280        290        300
ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTELNGT NGSVEADGIV 
       310        320        330        340        350
WNSLDVYLND PANYLLKNGT TDVLLCGNSS DAGTCPEGYR CLKAGENPDH 
       360        370        380        390        400
GYTSFDSFAW AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG 
       410        420        430        440        450
SFYLVNLILA VVAMAYEEQN QATIAETEEK EKRFQEAMEM LKKEHEALTI 
       460        470        480        490        500
RGVDTVSRSS LEMSPLAPVT NHERRSKRRK RLSSGTEDGG DDRLPKSDSE 
       510        520        530        540        550
DGPRALNQLS LTHGLSRTSM RPRSSRGSIF TFRRRDQGSE ADFADDENST 
       560        570        580        590        600
AGESESHRTS LLVPWPLRRP STQGQPGFGT SAPGHVLNGK RNSTVDCNGV 
       610        620        630        640        650
VSLLGAGDAE ATSPGSHLLR PIVLDRPPDT TTPSEEPGGP QMLTPQAPCA 
       660        670        680        690        700
DGFEEPGARQ RALSAVSVLT SALEELEESH RKCPPCWNRF AQHYLIWECC 
       710        720        730        740        750
PLWMSIKQKV KFVVMDPFAD LTITMCIVLN TLFMALEHYN MTAEFEEMLQ 
       760        770        780        790        800
VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG WNIFDSIIVI LSLMELGLSR 
       810        820        830        840        850
MGNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG NLTLVLAIIV 
       860        870        880        890        900
FIFAVVGMQL FGKNYSELRH RISDSGLLPR WHMMDFFHAF LIIFRILCGE 
       910        920        930        940        950
WIETMWDCME VSGQSLCLLV FLLVMVIGNL VVLNLFLALL LSSFSADNLT 
       960        970        980        990       1000
APDEDGEMNN LQLALARIQR GLRFVKRTTW DFCCGLLRRR PKKPAALATH 
      1010       1020       1030       1040       1050
SQLPSCIAAP RSPPPPEVEK APPARKETRF EEDKRPGQGT PGDTEPVCVP 
      1060       1070       1080       1090       1100
IAVAESDTDD QEEDEENSLG TEEEESSKQE SQVVSGGHEP PQEPRAWSQV 
      1110       1120       1130       1140       1150
SETTSSEAEA STSQADWQQE REAEPRAPGC GETPEDSYSE GSTADMTNTA 
      1160       1170       1180       1190       1200
DLLEQIPDLG EDVKDPEDCF TEGCVRRCPC CMVDTTQAPG KVWWRLRKTC 
      1210       1220       1230       1240       1250
YRIVEHSWFE TFIIFMILLS SGALAFEDIY LEERKTIKVL LEYADKMFTY 
      1260       1270       1280       1290       1300
VFVLEMLLKW VAYGFKKYFT NAWCWLDFLI VDVSLVSLVA NTLGFAEMGP 
      1310       1320       1330       1340       1350
IKSLRTLRAL RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF 
      1360       1370       1380       1390       1400
SIMGVNLFAG KFGRCINQTE GDLPLNYTIV NNKSECESFN VTGELYWTKV 
      1410       1420       1430       1440       1450
KVNFDNVGAG YLALLQVATF KGWMDIMYAA VDSRGYEEQP QWEDNLYMYI 
      1460       1470       1480       1490       1500
YFVVFIIFGS FFTLNLFIGV IIDNFNQQKK KLGGQDIFMT EEQKKYYNAM 
      1510       1520       1530       1540       1550
KKLGSKKPQK PIPRPLNKYQ GFIFDIVTKQ AFDVTIMFLI CLNMVTMMVE 
      1560       1570       1580       1590       1600
TDDQSPEKVN ILAKINLLFV AIFTGECIVK MAALRHYYFT NSWNIFDFVV 
      1610       1620       1630       1640       1650
VILSIVGTVL SDIIQKYFFS PTLFRVIRLA RIGRILRLIR GAKGIRTLLF 
      1660       1670       1680       1690       1700
ALMMSLPALF NIGLLLFLVM FIYSIFGMAN FAYVKWEAGI DDMFNFQTFA 
      1710       1720       1730       1740       1750
NSMLCLFQIT TSAGWDGLLS PILNTGPPYC DPNLPNSNGS RGNCGSPAVG 
      1760       1770       1780       1790       1800
ILFFTTYIII SFLIVVNMYI AIILENFSVA TEESTEPLSE DDFDMFYEIW 
      1810       1820       1830       1840       1850
EKFDPEATQF IEYLALSDFA DALSEPLRIA KPNQISLINM DLPMVSGDRI 
      1860       1870       1880       1890       1900
HCMDILFAFT KRVLGESGEM DALKIQMEEK FMAANPSKIS YEPITTTLRR 
      1910       1920       1930       1940       1950
KHEEVSATVI QRAFRRHLLQ RSVKHASFLF RQQAGSSGLS DEDAPEREGL 
      1960       1970       1980       1990       2000
IAYMMNENFS RRSGPLSSSS ISSTSFPPSY DSVTRATSDN LPVRASDYSR 
      2010 
SEDLADFPPS PDRDRESIV                                   

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families