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Protein

Beta-crystallin A4

Gene

Cryba4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin A4
Alternative name(s):
Beta-A4 crystallin
Gene namesi
Name:Cryba4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:102716 Cryba4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000575462 – 196Beta-crystallin A4Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9JJV0
PaxDbiQ9JJV0
PRIDEiQ9JJV0

PTM databases

PhosphoSitePlusiQ9JJV0

Expressioni

Gene expression databases

BgeeiENSMUSG00000066975
CleanExiMM_CRYBA4
ExpressionAtlasiQ9JJV0 baseline and differential
GenevisibleiQ9JJV0 MM

Interactioni

Subunit structurei

Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083826

Structurei

3D structure databases

ProteinModelPortaliQ9JJV0
SMRiQ9JJV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 51Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST40
Domaini52 – 98Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST47
Domaini105 – 146Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST42
Domaini147 – 195Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 11N-terminal arm10
Regioni99 – 104Connecting peptide6

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IE7N Eukaryota
ENOG410YIM8 LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234388
HOVERGENiHBG003364
InParanoidiQ9JJV0
OMAiWDGNEVG
OrthoDBiEOG091G0JYH
PhylomeDBiQ9JJV0
TreeFamiTF331401

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR033342 CRYBA4
IPR011024 G_crystallin-like
PANTHERiPTHR11818:SF19 PTHR11818:SF19, 1 hit
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLQCTKSAG HWRMVVWDEE GFQGRRHEFT AECPSVLELG FETVRSLKVL
60 70 80 90 100
SGAWVGFEHA GFQGQQYVLE RGDYPGWDAW GGNTAYPAER LTSFRPVACA
110 120 130 140 150
NHRDSRLTIF EQENFLGRKG ELNDDYPSLQ AMGWDGTEVG SFHVQSGAWV
160 170 180 190
CSQFPGYRGF QYILESDHHS GDYKHFREWG SHAHTFQVQS VRRIQQ
Length:196
Mass (Da):22,469
Last modified:January 23, 2007 - v3
Checksum:i5911B1C784DD253B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272228 mRNA Translation: CAB75586.1
BC056444 mRNA Translation: AAH56444.1
BC058703 mRNA Translation: AAH58703.1
CCDSiCCDS19536.1
RefSeqiNP_001299813.1, NM_001312884.1
NP_067326.1, NM_021351.2
UniGeneiMm.40324

Genome annotation databases

EnsembliENSMUST00000086629; ENSMUSP00000083826; ENSMUSG00000066975
ENSMUST00000112385; ENSMUSP00000108004; ENSMUSG00000066975
GeneIDi12959
KEGGimmu:12959
UCSCiuc008yst.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCRBA4_MOUSE
AccessioniPrimary (citable) accession number: Q9JJV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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