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Protein

Beta-crystallin B3

Gene

Crybb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin B3
Alternative name(s):
Beta-B3 crystallin
Cleaved into the following chain:
Gene namesi
Name:Crybb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:102717 Crybb3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004217751 – 211Beta-crystallin B3Add BLAST211
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00000575612 – 211Beta-crystallin B3, N-terminally processedAdd BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylalanine; in Beta-crystallin B3, N-terminally processedBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9JJU9
PaxDbiQ9JJU9
PRIDEiQ9JJU9

PTM databases

iPTMnetiQ9JJU9
PhosphoSitePlusiQ9JJU9

Expressioni

Gene expression databases

BgeeiENSMUSG00000029352 Expressed in 75 organ(s), highest expression level in camera-type eye
CleanExiMM_CRYBB3
ExpressionAtlasiQ9JJU9 baseline and differential
GenevisibleiQ9JJU9 MM

Interactioni

Subunit structurei

Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075440

Structurei

3D structure databases

ProteinModelPortaliQ9JJU9
SMRiQ9JJU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 63Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST40
Domaini64 – 108Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST45
Domaini114 – 155Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST42
Domaini156 – 198Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 23N-terminal armAdd BLAST22
Regioni109 – 113Connecting peptide5
Regioni200 – 211C-terminal armAdd BLAST12

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJYD Eukaryota
ENOG410Y7P1 LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234388
HOVERGENiHBG003364
InParanoidiQ9JJU9
OMAiEYPRWST
OrthoDBiEOG091G0JIZ
PhylomeDBiQ9JJU9
TreeFamiTF331401

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR033115 CRYBB3
IPR011024 G_crystallin-like
PANTHERiPTHR11818:SF13 PTHR11818:SF13, 1 hit
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9JJU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEQHGAPEQ AAAGKSHGGL GGSYKVTVYE LENFQGKRCE LSAECPNLTD
60 70 80 90 100
SLLEKVGSIQ VESGPWLAFE RRAFRGEQFV LEKGDYPRWD AWSSSRRSDI
110 120 130 140 150
LLSLRPLHID GPDHKLHLFE NPAFSGRKME IVDDDVPSLW AHGFQDRVAS
160 170 180 190 200
IRVINGTWVG YEFPGYRGRQ YVFERGEFRH WNEWDANQPQ LQSVRRIRDQ
210
KWHKRGCFLS S
Length:211
Mass (Da):24,291
Last modified:January 23, 2007 - v3
Checksum:i2F23F47987102196
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YYW5D3YYW5_MOUSE
Beta-crystallin B3
Crybb3
79Annotation score:
D3Z1U1D3Z1U1_MOUSE
Beta-crystallin B3
Crybb3
119Annotation score:
D3Z2L5D3Z2L5_MOUSE
Beta-crystallin B3
Crybb3
65Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272229 mRNA Translation: CAB75587.1
BC031442 mRNA Translation: AAH31442.1
BC058522 mRNA Translation: AAH58522.1
CCDSiCCDS19547.1
RefSeqiNP_001153122.1, NM_001159650.1
NP_067327.1, NM_021352.3
XP_006534825.1, XM_006534762.2
UniGeneiMm.378899

Genome annotation databases

EnsembliENSMUST00000076069; ENSMUSP00000075440; ENSMUSG00000029352
ENSMUST00000117143; ENSMUSP00000113347; ENSMUSG00000029352
ENSMUST00000118226; ENSMUSP00000112618; ENSMUSG00000029352
ENSMUST00000119627; ENSMUSP00000113572; ENSMUSG00000029352
ENSMUST00000120506; ENSMUSP00000112718; ENSMUSG00000029352
GeneIDi12962
KEGGimmu:12962
UCSCiuc012ebl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272229 mRNA Translation: CAB75587.1
BC031442 mRNA Translation: AAH31442.1
BC058522 mRNA Translation: AAH58522.1
CCDSiCCDS19547.1
RefSeqiNP_001153122.1, NM_001159650.1
NP_067327.1, NM_021352.3
XP_006534825.1, XM_006534762.2
UniGeneiMm.378899

3D structure databases

ProteinModelPortaliQ9JJU9
SMRiQ9JJU9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075440

PTM databases

iPTMnetiQ9JJU9
PhosphoSitePlusiQ9JJU9

Proteomic databases

MaxQBiQ9JJU9
PaxDbiQ9JJU9
PRIDEiQ9JJU9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076069; ENSMUSP00000075440; ENSMUSG00000029352
ENSMUST00000117143; ENSMUSP00000113347; ENSMUSG00000029352
ENSMUST00000118226; ENSMUSP00000112618; ENSMUSG00000029352
ENSMUST00000119627; ENSMUSP00000113572; ENSMUSG00000029352
ENSMUST00000120506; ENSMUSP00000112718; ENSMUSG00000029352
GeneIDi12962
KEGGimmu:12962
UCSCiuc012ebl.1 mouse

Organism-specific databases

CTDi1417
MGIiMGI:102717 Crybb3

Phylogenomic databases

eggNOGiENOG410IJYD Eukaryota
ENOG410Y7P1 LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234388
HOVERGENiHBG003364
InParanoidiQ9JJU9
OMAiEYPRWST
OrthoDBiEOG091G0JIZ
PhylomeDBiQ9JJU9
TreeFamiTF331401

Miscellaneous databases

ChiTaRSiCrybb3 mouse
PROiPR:Q9JJU9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029352 Expressed in 75 organ(s), highest expression level in camera-type eye
CleanExiMM_CRYBB3
ExpressionAtlasiQ9JJU9 baseline and differential
GenevisibleiQ9JJU9 MM

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR033115 CRYBB3
IPR011024 G_crystallin-like
PANTHERiPTHR11818:SF13 PTHR11818:SF13, 1 hit
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRBB3_MOUSE
AccessioniPrimary (citable) accession number: Q9JJU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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