UniProtKB - Q9JJS6 (BCDO1_MOUSE)
Protein
Beta,beta-carotene 15,15'-dioxygenase
Gene
Bco1
Organism
Mus musculus (Mouse)
Status
Functioni
Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism.By similarity
Catalytic activityi
- EC:1.13.11.631 Publication
Cofactori
Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity
: retinol metabolism Pathwayi
This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 172 | Iron; catalyticBy similarity | 1 | |
Metal bindingi | 237 | Iron; catalyticBy similarity | 1 | |
Metal bindingi | 308 | Iron; catalyticBy similarity | 1 | |
Metal bindingi | 514 | Iron; catalyticBy similarity | 1 |
GO - Molecular functioni
- beta-carotene 15,15'-monooxygenase activity Source: UniProtKB
- carotenoid dioxygenase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- beta-carotene metabolic process Source: MGI
- carotene catabolic process Source: GO_Central
- retinal metabolic process Source: MGI
- retinoid metabolic process Source: UniProtKB
- retinol metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.13.11.63, 3474 1.14.99.36, 3474 |
Reactomei | R-MMU-975634, Retinoid metabolism and transport |
SABIO-RKi | Q9JJS6 |
UniPathwayi | UPA00912 |
Names & Taxonomyi
Protein namesi | Recommended name: Beta,beta-carotene 15,15'-dioxygenase (EC:1.13.11.63By similarity)Alternative name(s): Beta-carotene dioxygenase 1 Beta-carotene oxygenase 1By similarity |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1926923, Bco1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143934 | 1 – 566 | Beta,beta-carotene 15,15'-dioxygenaseAdd BLAST | 566 |
Proteomic databases
EPDi | Q9JJS6 |
MaxQBi | Q9JJS6 |
PaxDbi | Q9JJS6 |
PRIDEi | Q9JJS6 |
PTM databases
iPTMneti | Q9JJS6 |
PhosphoSitePlusi | Q9JJS6 |
Expressioni
Tissue specificityi
Expressed in liver, kidney, small intestine and testis.1 Publication
Developmental stagei
Abundantly expressed at embryonic day 7 with lower levels at embryonic days 11, 13 and 15.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000031845, Expressed in decidua and 110 other tissues |
ExpressionAtlasi | Q9JJS6, baseline and differential |
Genevisiblei | Q9JJS6, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034308 |
Miscellaneous databases
RNActi | Q9JJS6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the carotenoid oxygenase family.Curated
Phylogenomic databases
eggNOGi | KOG1285, Eukaryota |
GeneTreei | ENSGT00950000182913 |
HOGENOMi | CLU_016472_1_1_1 |
InParanoidi | Q9JJS6 |
OMAi | PGMHTIG |
OrthoDBi | 524712at2759 |
PhylomeDBi | Q9JJS6 |
TreeFami | TF314019 |
Family and domain databases
InterProi | View protein in InterPro IPR004294, Carotenoid_Oase |
PANTHERi | PTHR10543, PTHR10543, 1 hit |
Pfami | View protein in Pfam PF03055, RPE65, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9JJS6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEIIFGQNKK EQLEPVQAKV TGSIPAWLQG TLLRNGPGMH TVGESKYNHW
60 70 80 90 100
FDGLALLHSF SIRDGEVFYR SKYLQSDTYI ANIEANRIVV SEFGTMAYPD
110 120 130 140 150
PCKNIFSKAF SYLSHTIPDF TDNCLINIMK CGEDFYATTE TNYIRKIDPQ
160 170 180 190 200
TLETLEKVDY RKYVAVNLAT SHPHYDEAGN VLNMGTSVVD KGRTKYVIFK
210 220 230 240 250
IPATVPDSKK KGKSPVKHAE VFCSISSRSL LSPSYYHSFG VTENYVVFLE
260 270 280 290 300
QPFKLDILKM ATAYMRGVSW ASCMSFDRED KTYIHIIDQR TRKPVPTKFY
310 320 330 340 350
TDPMVVFHHV NAYEEDGCVL FDVIAYEDSS LYQLFYLANL NKDFEEKSRL
360 370 380 390 400
TSVPTLRRFA VPLHVDKDAE VGSNLVKVSS TTATALKEKD GHVYCQPEVL
410 420 430 440 450
YEGLELPRIN YAYNGKPYRY IFAAEVQWSP VPTKILKYDI LTKSSLKWSE
460 470 480 490 500
ESCWPAEPLF VPTPGAKDED DGVILSAIVS TDPQKLPFLL ILDAKSFTEL
510 520 530 540 550
ARASVDADMH LDLHGLFIPD ADWNAVKQTP AETQEVENSD HPTDPTAPEL
560
SHSENDFTAG HGGSSL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9Q321 | E9Q321_MOUSE | Beta,beta-carotene 15,15'-dioxygena... | Bco1 Bcmo1 | 526 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 409 | I → T in AAG15381 (PubMed:11401432).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ278064 mRNA Translation: CAB92531.2 AF271298 mRNA Translation: AAG33982.1 AF294899 mRNA Translation: AAG15381.1 AY114302 , AY114294, AY114295, AY114296, AY114297, AY114298, AY114299, AY114300, AY114301 Genomic DNA Translation: AAM76677.1 AK054171 mRNA Translation: BAC35679.1 |
CCDSi | CCDS22697.1 |
RefSeqi | NP_067461.2, NM_021486.3 |
Genome annotation databases
Ensembli | ENSMUST00000034308; ENSMUSP00000034308; ENSMUSG00000031845 |
GeneIDi | 63857 |
KEGGi | mmu:63857 |
UCSCi | uc009now.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ278064 mRNA Translation: CAB92531.2 AF271298 mRNA Translation: AAG33982.1 AF294899 mRNA Translation: AAG15381.1 AY114302 , AY114294, AY114295, AY114296, AY114297, AY114298, AY114299, AY114300, AY114301 Genomic DNA Translation: AAM76677.1 AK054171 mRNA Translation: BAC35679.1 |
CCDSi | CCDS22697.1 |
RefSeqi | NP_067461.2, NM_021486.3 |
3D structure databases
SMRi | Q9JJS6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034308 |
PTM databases
iPTMneti | Q9JJS6 |
PhosphoSitePlusi | Q9JJS6 |
Proteomic databases
EPDi | Q9JJS6 |
MaxQBi | Q9JJS6 |
PaxDbi | Q9JJS6 |
PRIDEi | Q9JJS6 |
Protocols and materials databases
Antibodypediai | 48219, 122 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034308; ENSMUSP00000034308; ENSMUSG00000031845 |
GeneIDi | 63857 |
KEGGi | mmu:63857 |
UCSCi | uc009now.2, mouse |
Organism-specific databases
CTDi | 53630 |
MGIi | MGI:1926923, Bco1 |
Phylogenomic databases
eggNOGi | KOG1285, Eukaryota |
GeneTreei | ENSGT00950000182913 |
HOGENOMi | CLU_016472_1_1_1 |
InParanoidi | Q9JJS6 |
OMAi | PGMHTIG |
OrthoDBi | 524712at2759 |
PhylomeDBi | Q9JJS6 |
TreeFami | TF314019 |
Enzyme and pathway databases
UniPathwayi | UPA00912 |
BRENDAi | 1.13.11.63, 3474 1.14.99.36, 3474 |
Reactomei | R-MMU-975634, Retinoid metabolism and transport |
SABIO-RKi | Q9JJS6 |
Miscellaneous databases
BioGRID-ORCSi | 63857, 1 hit in 17 CRISPR screens |
PROi | PR:Q9JJS6 |
RNActi | Q9JJS6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031845, Expressed in decidua and 110 other tissues |
ExpressionAtlasi | Q9JJS6, baseline and differential |
Genevisiblei | Q9JJS6, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004294, Carotenoid_Oase |
PANTHERi | PTHR10543, PTHR10543, 1 hit |
Pfami | View protein in Pfam PF03055, RPE65, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BCDO1_MOUSE | |
Accessioni | Q9JJS6Primary (citable) accession number: Q9JJS6 Secondary accession number(s): Q6K1L5, Q8C6N5, Q9ERN9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families