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UniProtKB - Q9JJR7 (ASCL3_MOUSE)
Protein
Achaete-scute homolog 3
Gene
Ascl3
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional repressor. Inhibits myogenesis.
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Achaete-scute homolog 3Short name: ASH-3 Short name: mASH-3 Short name: mASH3 Alternative name(s): bHLH transcriptional regulator Sgn-1 |
Gene namesi | Name:Ascl3 Synonyms:Mash3, Sgn1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1928820, Ascl3 |
VEuPathDBi | HostDB:ENSMUSG00000035951 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: MGI
- RNA polymerase II transcription regulator complex Source: GO_Central
Other locations
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127134 | 1 – 174 | Achaete-scute homolog 3Add BLAST | 174 |
Proteomic databases
PaxDbi | Q9JJR7 |
PRIDEi | Q9JJR7 |
PTM databases
PhosphoSitePlusi | Q9JJR7 |
Expressioni
Tissue specificityi
Specifically expressed in the salivary duct cells.
Gene expression databases
Bgeei | ENSMUSG00000035951, Expressed in saliva-secreting gland and 76 other tissues |
Genevisiblei | Q9JJR7, MM |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 208173, 5 interactors |
STRINGi | 10090.ENSMUSP00000037702 |
Miscellaneous databases
RNActi | Q9JJR7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 92 – 144 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 153 – 174 | DisorderedSequence analysisAdd BLAST | 22 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000162850 |
HOGENOMi | CLU_128274_0_0_1 |
InParanoidi | Q9JJR7 |
OMAi | DPIFRIV |
OrthoDBi | 1545499at2759 |
PhylomeDBi | Q9JJR7 |
TreeFami | TF322889 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR015660, MASH1/Ascl1a-like |
PANTHERi | PTHR13935, PTHR13935, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9JJR7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTRSYPSPP DRLSVFAESA HLPLSRPFYL DPMVTVHLCP ETPVPASYTD
60 70 80 90 100
ELPLLPFSSD TLIMNNYGDP YPFPFPMPYT NYRRCDYTYG PAFIRKRNER
110 120 130 140 150
ERQRVKCVNE GYARLRRHLP EDYLEKRLSK VETLRAAIKY ISYLQSLLYP
160 170
DESETKKNPR TASCGSLDPA LRVI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ277605 mRNA Translation: CAC37689.1 AB046448 mRNA Translation: BAB83911.1 AJ400878 Genomic DNA Translation: CAB92296.1 BC104346 mRNA Translation: AAI04347.1 BC104347 mRNA Translation: AAI04348.1 |
CCDSi | CCDS21737.1 |
RefSeqi | NP_064435.1, NM_020051.1 |
Genome annotation databases
Ensembli | ENSMUST00000035372; ENSMUSP00000037702; ENSMUSG00000035951 |
GeneIDi | 56787 |
KEGGi | mmu:56787 |
UCSCi | uc009jeb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ277605 mRNA Translation: CAC37689.1 AB046448 mRNA Translation: BAB83911.1 AJ400878 Genomic DNA Translation: CAB92296.1 BC104346 mRNA Translation: AAI04347.1 BC104347 mRNA Translation: AAI04348.1 |
CCDSi | CCDS21737.1 |
RefSeqi | NP_064435.1, NM_020051.1 |
3D structure databases
SMRi | Q9JJR7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 208173, 5 interactors |
STRINGi | 10090.ENSMUSP00000037702 |
PTM databases
PhosphoSitePlusi | Q9JJR7 |
Proteomic databases
PaxDbi | Q9JJR7 |
PRIDEi | Q9JJR7 |
Protocols and materials databases
Antibodypediai | 24178, 89 antibodies from 24 providers |
DNASUi | 56787 |
Genome annotation databases
Ensembli | ENSMUST00000035372; ENSMUSP00000037702; ENSMUSG00000035951 |
GeneIDi | 56787 |
KEGGi | mmu:56787 |
UCSCi | uc009jeb.1, mouse |
Organism-specific databases
CTDi | 56676 |
MGIi | MGI:1928820, Ascl3 |
VEuPathDBi | HostDB:ENSMUSG00000035951 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000162850 |
HOGENOMi | CLU_128274_0_0_1 |
InParanoidi | Q9JJR7 |
OMAi | DPIFRIV |
OrthoDBi | 1545499at2759 |
PhylomeDBi | Q9JJR7 |
TreeFami | TF322889 |
Miscellaneous databases
BioGRID-ORCSi | 56787, 2 hits in 65 CRISPR screens |
ChiTaRSi | Gps1, mouse |
PROi | PR:Q9JJR7 |
RNActi | Q9JJR7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000035951, Expressed in saliva-secreting gland and 76 other tissues |
Genevisiblei | Q9JJR7, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR015660, MASH1/Ascl1a-like |
PANTHERi | PTHR13935, PTHR13935, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ASCL3_MOUSE | |
Accessioni | Q9JJR7Primary (citable) accession number: Q9JJR7 Secondary accession number(s): Q3SXE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot