Ascl3

Functionⁱ

Transcriptional repressor. Inhibits myogenesis.

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 11784080
protein dimerization activity Source: InterPro
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 11784080
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 11784080

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 11784080
regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 11784080
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Achaete-scute homolog 3 Short name: ASH-3 Short name: mASH-3 Short name: mASH3 Alternative name(s): bHLH transcriptional regulator Sgn-1
Gene namesⁱ	Name:Ascl3 Synonyms:Mash3, Sgn1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1928820 Ascl3

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127134	1 – 174	Achaete-scute homolog 3Add BLAST		174

Proteomic databases

PaxDbⁱ	Q9JJR7
PRIDEⁱ	Q9JJR7

PTM databases

PhosphoSitePlusⁱ	Q9JJR7

PhosphoSitePlusⁱ

Q9JJR7

Expressionⁱ

Tissue specificityⁱ

Specifically expressed in the salivary duct cells.

Gene expression databases

Bgeeⁱ	ENSMUSG00000035951 Expressed in 36 organ(s), highest expression level in saliva-secreting gland
CleanExⁱ	MM_ASCL3
Genevisibleⁱ	Q9JJR7 MM

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	208173, 5 interactors
STRINGⁱ	10090.ENSMUSP00000037702

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9JJR7
SMRⁱ	Q9JJR7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	92 – 144	bHLHPROSITE-ProRule annotationAdd BLAST		53

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063321
HOGENOMⁱ	HOG000034089
HOVERGENⁱ	HBG050591
InParanoidⁱ	Q9JJR7
KEGG Orthology (KO) More...KOⁱ	K09067
OMAⁱ	GYAQLRH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OGL
PhylomeDBⁱ	Q9JJR7
TreeFamⁱ	TF322889

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR015660 MASH1/Ascl1a-like
PANTHERⁱ	PTHR13935 PTHR13935, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9JJR7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDTRSYPSPP DRLSVFAESA HLPLSRPFYL DPMVTVHLCP ETPVPASYTD 
        60         70         80         90        100
ELPLLPFSSD TLIMNNYGDP YPFPFPMPYT NYRRCDYTYG PAFIRKRNER 
       110        120        130        140        150
ERQRVKCVNE GYARLRRHLP EDYLEKRLSK VETLRAAIKY ISYLQSLLYP 
       160        170 
DESETKKNPR TASCGSLDPA LRVI

Length:174

Mass (Da):20,245

Last modified:October 1, 2000 - v1

Checksum:ⁱD89E56C8A9D3440B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ277605 mRNA Translation: CAC37689.1 AB046448 mRNA Translation: BAB83911.1 AJ400878 Genomic DNA Translation: CAB92296.1 BC104346 mRNA Translation: AAI04347.1 BC104347 mRNA Translation: AAI04348.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21737.1
NCBI Reference Sequences More...RefSeqⁱ	NP_064435.1, NM_020051.1
UniGeneⁱ	Mm.29275

Genome annotation databases

Ensemblⁱ	ENSMUST00000035372; ENSMUSP00000037702; ENSMUSG00000035951
GeneIDⁱ	56787
KEGGⁱ	mmu:56787
UCSC genome browser More...UCSCⁱ	uc009jeb.1 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9JJR7	Achaete-scute homolog 3		HUMAN		180	UniRef50_Q9JJR7
Uncharacterized protein		CHICK		180
Uncharacterized protein		CALSU		180
Achaete-scute family bHLH transcription factor 3		MELGA		180
Achaete-scute family bHLH transcription factor 3		TAEGU		129
+181

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ277605 mRNA Translation: CAC37689.1 AB046448 mRNA Translation: BAB83911.1 AJ400878 Genomic DNA Translation: CAB92296.1 BC104346 mRNA Translation: AAI04347.1 BC104347 mRNA Translation: AAI04348.1
CCDSⁱ	CCDS21737.1
RefSeqⁱ	NP_064435.1, NM_020051.1
UniGeneⁱ	Mm.29275

3D structure databases

ProteinModelPortalⁱ	Q9JJR7
SMRⁱ	Q9JJR7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	208173, 5 interactors
STRINGⁱ	10090.ENSMUSP00000037702

PTM databases

PhosphoSitePlusⁱ	Q9JJR7

PhosphoSitePlusⁱ

Q9JJR7

Proteomic databases

PaxDbⁱ	Q9JJR7
PRIDEⁱ	Q9JJR7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000035372; ENSMUSP00000037702; ENSMUSG00000035951
GeneIDⁱ	56787
KEGGⁱ	mmu:56787
UCSCⁱ	uc009jeb.1 mouse

Organism-specific databases

CTDⁱ	56676
MGIⁱ	MGI:1928820 Ascl3

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
GeneTreeⁱ	ENSGT00530000063321
HOGENOMⁱ	HOG000034089
HOVERGENⁱ	HBG050591
InParanoidⁱ	Q9JJR7
KOⁱ	K09067
OMAⁱ	GYAQLRH
OrthoDBⁱ	EOG091G0OGL
PhylomeDBⁱ	Q9JJR7
TreeFamⁱ	TF322889

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9JJR7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000035951 Expressed in 36 organ(s), highest expression level in saliva-secreting gland
CleanExⁱ	MM_ASCL3
Genevisibleⁱ	Q9JJR7 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR015660 MASH1/Ascl1a-like
PANTHERⁱ	PTHR13935 PTHR13935, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ASCL3_MOUSE
Accessionⁱ	Q9JJR7Primary (citable) accession number: Q9JJR7 Secondary accession number(s): Q3SXE3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9JJR7 (ASCL3_MOUSE)

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Achaete-scute homolog 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ