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Protein

A-kinase-interacting protein 1

Gene

Akip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity).By similarity

GO - Biological processi

  • regulation of NIK/NF-kappaB signaling Source: InterPro
  • substrate adhesion-dependent cell spreading Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase-interacting protein 1
Alternative name(s):
Breast cancer-associated gene 3 protein
PKA-interacting protein
Proline-rich protein BCA3
Gene namesi
Name:Akip1
Synonyms:Bca3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3041226 Akip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648581 – 212A-kinase-interacting protein 1Add BLAST212

Proteomic databases

MaxQBiQ9JJR5
PaxDbiQ9JJR5
PRIDEiQ9JJR5

PTM databases

iPTMnetiQ9JJR5
PhosphoSitePlusiQ9JJR5

Expressioni

Gene expression databases

BgeeiENSMUSG00000031023 Expressed in 236 organ(s), highest expression level in testis
CleanExiMM_D930014E17RIK
ExpressionAtlasiQ9JJR5 baseline and differential
GenevisibleiQ9JJR5 MM

Interactioni

Subunit structurei

Interacts with PRKACA and RELA.By similarity

Protein-protein interaction databases

BioGridi208274, 1 interactor
STRINGi10090.ENSMUSP00000033335

Structurei

3D structure databases

ProteinModelPortaliQ9JJR5
SMRiQ9JJR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IGJ9 Eukaryota
ENOG41114P0 LUCA
GeneTreeiENSGT00390000017064
HOVERGENiHBG030457
InParanoidiQ9JJR5
OMAiREERHPT
OrthoDBiEOG091G0W3L
PhylomeDBiQ9JJR5
TreeFamiTF337318

Family and domain databases

InterProiView protein in InterPro
IPR033214 AKIP1
PANTHERiPTHR14330 PTHR14330, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JJR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEYCLAAAAL NGVDRRSLQR SARLGREVLE RAKRRAVDWH SPERSRGNVG
60 70 80 90 100
VLYRQGPYQE RWSVPGSQRL LGEREERCPT LSSSFGAMAE FMDYTSSQCG
110 120 130 140 150
KYYLSMPEEG GATHVYRYHR RKPPEMHMYS DTGHSQEQRN CRGETSVGQE
160 170 180 190 200
SIYQTSEHSQ ESSWPTENIS KDLYIEVYPG TYSVTVGSSA LSKKTHVVAV
210
DPGQSVDLVF PV
Length:212
Mass (Da):23,979
Last modified:October 1, 2000 - v1
Checksum:iABF9916CF5031C56
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YXP0D3YXP0_MOUSE
A-kinase-interacting protein 1
Akip1 D930014E17Rik
153Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400878 Genomic DNA Translation: CAB92298.1
AK086219 mRNA Translation: BAC39632.1
AK163012 mRNA Translation: BAE37154.1
CCDSiCCDS21736.1
RefSeqiNP_065641.1, NM_020616.1
UniGeneiMm.334138

Genome annotation databases

EnsembliENSMUST00000033335; ENSMUSP00000033335; ENSMUSG00000031023
GeneIDi57373
KEGGimmu:57373
UCSCiuc009jdy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400878 Genomic DNA Translation: CAB92298.1
AK086219 mRNA Translation: BAC39632.1
AK163012 mRNA Translation: BAE37154.1
CCDSiCCDS21736.1
RefSeqiNP_065641.1, NM_020616.1
UniGeneiMm.334138

3D structure databases

ProteinModelPortaliQ9JJR5
SMRiQ9JJR5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208274, 1 interactor
STRINGi10090.ENSMUSP00000033335

PTM databases

iPTMnetiQ9JJR5
PhosphoSitePlusiQ9JJR5

Proteomic databases

MaxQBiQ9JJR5
PaxDbiQ9JJR5
PRIDEiQ9JJR5

Protocols and materials databases

DNASUi57373
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033335; ENSMUSP00000033335; ENSMUSG00000031023
GeneIDi57373
KEGGimmu:57373
UCSCiuc009jdy.1 mouse

Organism-specific databases

CTDi56672
MGIiMGI:3041226 Akip1

Phylogenomic databases

eggNOGiENOG410IGJ9 Eukaryota
ENOG41114P0 LUCA
GeneTreeiENSGT00390000017064
HOVERGENiHBG030457
InParanoidiQ9JJR5
OMAiREERHPT
OrthoDBiEOG091G0W3L
PhylomeDBiQ9JJR5
TreeFamiTF337318

Miscellaneous databases

PROiPR:Q9JJR5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031023 Expressed in 236 organ(s), highest expression level in testis
CleanExiMM_D930014E17RIK
ExpressionAtlasiQ9JJR5 baseline and differential
GenevisibleiQ9JJR5 MM

Family and domain databases

InterProiView protein in InterPro
IPR033214 AKIP1
PANTHERiPTHR14330 PTHR14330, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAKIP1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJR5
Secondary accession number(s): Q3TR76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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