UniProtKB - Q9JJP2 (P73_MOUSE)
Tumor protein p73
Tp73
Functioni
Miscellaneous
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 186 | ZincBy similarity | 1 | |
Metal bindingi | 189 | ZincBy similarity | 1 | |
Metal bindingi | 250 | ZincBy similarity | 1 | |
Metal bindingi | 254 | ZincBy similarity | 1 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- identical protein binding Source: MGI
- MDM2/MDM4 family protein binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- p53 binding Source: MGI
- protein kinase binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: MGI
- transcription factor binding Source: MGI
- transcription regulatory region sequence-specific DNA binding Source: MGI
GO - Biological processi
- activation of MAPK activity Source: MGI
- cell cycle arrest Source: MGI
- cellular response to DNA damage stimulus Source: MGI
- cerebrospinal fluid secretion Source: MGI
- digestive tract morphogenesis Source: MGI
- forebrain development Source: MGI
- hippocampus development Source: MGI
- inflammatory response Source: MGI
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: UniProtKB
- negative regulation of cardiac muscle cell proliferation Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of JUN kinase activity Source: MGI
- negative regulation of neuron apoptotic process Source: MGI
- negative regulation of neuron differentiation Source: MGI
- neuron development Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of apoptotic signaling pathway Source: MGI
- positive regulation of cell cycle arrest Source: MGI
- positive regulation of cell size Source: MGI
- positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
- positive regulation of oligodendrocyte differentiation Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- post-embryonic development Source: MGI
- protein tetramerization Source: InterPro
- regulation of gene expression Source: MGI
- regulation of mitotic cell cycle Source: MGI
- regulation of neuron apoptotic process Source: MGI
- release of cytochrome c from mitochondria Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Apoptosis, Cell cycle, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-6804759, Regulation of TP53 Activity through Association with Co-factors R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor protein p73By similarityAlternative name(s): p53-like transcription factorBy similarity p53-related proteinBy similarity |
Gene namesi | Name:Tp73 Synonyms:P73Imported, Trp73Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1336991, Trp73 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: ParkinsonsUK-UCL
Other locations
- cell junction Source: MGI
- chromatin Source: MGI
- cytoplasm Source: MGI
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
Keywords - Diseasei
Tumor suppressorPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000370211 | 1 – 631 | Tumor protein p73Add BLAST | 631 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | Phosphothreonine; by PLK1By similarity | 1 | |
Modified residuei | 25 | Phosphotyrosine; by SRC and HCKBy similarity | 1 | |
Modified residuei | 91 | Phosphotyrosine; by ABL1By similarity | 1 | |
Cross-linki | 622 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity | ||
Cross-linki | 622 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q9JJP2 |
PRIDEi | Q9JJP2 |
PTM databases
iPTMneti | Q9JJP2 |
PhosphoSitePlusi | Q9JJP2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000029026, Expressed in cerebral cortex and 96 other tissues |
ExpressionAtlasi | Q9JJP2, baseline and differential |
Genevisiblei | Q9JJP2, MM |
Interactioni
Subunit structurei
Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain.
Interacts with HECW2, HIPK2, RANBP9 and WWOX (By similarity).
Interacts (via SAM domain) with FBXO45 (via B30.2/SPRY domain) (By similarity).
Interacts with YAP1 (phosphorylated form) (By similarity).
Interacts with HCK (via SH3 domain); this inhibits TP73 activity and degradation (By similarity).
By similarityBinary interactionsi
Q9JJP2
With | #Exp. | IntAct |
---|---|---|
Yap1 [P46938] | 2 | EBI-1770138,EBI-1211949 |
GO - Molecular functioni
- identical protein binding Source: MGI
- MDM2/MDM4 family protein binding Source: MGI
- p53 binding Source: MGI
- protein kinase binding Source: MGI
- transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204326, 5 interactors |
DIPi | DIP-41942N |
IntActi | Q9JJP2, 3 interactors |
MINTi | Q9JJP2 |
STRINGi | 10090.ENSMUSP00000101269 |
Miscellaneous databases
RNActi | Q9JJP2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 479 – 545 | SAMSequence analysisAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 43 | TransactivationBy similarityAdd BLAST | 43 | |
Regioni | 123 – 302 | DNA-bindingBy similarityAdd BLAST | 180 | |
Regioni | 337 – 378 | OligomerizationSequence analysisAdd BLAST | 42 | |
Regioni | 337 – 372 | Interaction with HIPK2By similarityAdd BLAST | 36 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 477 – 481 | PPxY motifBy similarity | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 5 – 10 | Poly-SerSequence analysis | 6 | |
Compositional biasi | 383 – 388 | Poly-GlnSequence analysis | 6 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QQ48, Eukaryota |
GeneTreei | ENSGT00950000183153 |
HOGENOMi | CLU_019621_1_1_1 |
InParanoidi | Q9JJP2 |
OMAi | FQHLWSS |
OrthoDBi | 257530at2759 |
PhylomeDBi | Q9JJP2 |
TreeFami | TF106101 |
Family and domain databases
CDDi | cd08367, P53, 1 hit cd09571, SAM_tumor-p73, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.60.40.720, 1 hit 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR002117, p53_tumour_suppressor IPR001660, SAM IPR013761, SAM/pointed_sf IPR032646, Tp73 IPR037612, Tumour-p73_SAM |
PANTHERi | PTHR11447, PTHR11447, 1 hit PTHR11447:SF21, PTHR11447:SF21, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF07710, P53_tetramer, 1 hit PF07647, SAM_2, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47719, SSF47719, 1 hit SSF47769, SSF47769, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQTSSSSSS TFEHLWSSLE PDSTYFDLPQ PSQGTSEASG SEESNMDVFH
60 70 80 90 100
LQGMAQFNLL SSAMDQMGSR AAPASPYTPE HAASAPTHSP YAQPSSTFDT
110 120 130 140 150
MSPAPVIPSN TDYPGPHHFE VTFQQSSTAK SATWTYSPLL KKLYCQIAKT
160 170 180 190 200
CPIQIKVSTP PPPGTAIRAM PVYKKAEHVT DIVKRCPNHE LGRDFNEGQS
210 220 230 240 250
APASHLIRVE GNNLAQYVDD PVTGRQSVVV PYEPPQVGTE FTTILYNFMC
260 270 280 290 300
NSSCVGGMNR RPILVIITLE TRDGQVLGRR SFEGRICACP GRDRKADEDH
310 320 330 340 350
YREQQALNES TTKNGAASKR AFKQSPPAIP ALGTNVKKRR HGDEDMFYMH
360 370 380 390 400
VRGRENFEIL MKVKESLELM ELVPQPLVDS YRQQQQQQLL QRPSHLQPPS
410 420 430 440 450
YGPVLSPMNK VHGGVNKLPS VNQLVGQPPP HSSAAGPNLG PMGSGMLNSH
460 470 480 490 500
GHSMPANGEM NGGHSSQTMV SGSHCTPPPP YHADPSLVSF LTGLGCPNCI
510 520 530 540 550
ECFTSQGLQS IYHLQNLTIE DLGALKVPDQ YRMTIWRGLQ DLKQSHDCGQ
560 570 580 590 600
QLLRSSSNAA TISIGGSGEL QRQRVMEAVH FRVRHTITIP NRGGAGAVTG
610 620 630
PDEWADFGFD LPDCKSRKQP IKEEFTETES H
The sequence of this isoform differs from the canonical sequence as follows:
1-54: MAQTSSSSSSTFEHLWSSLEPDSTYFDLPQPSQGTSEASGSEESNMDVFHLQGM → MLYVGDPMRHLAT
The sequence of this isoform differs from the canonical sequence as follows:
1-54: MAQTSSSSSSTFEHLWSSLEPDSTYFDLPQPSQGTSEASGSEESNMDVFHLQGM → MLYVGDPMRHLAT
489-493: SFLTG → RTLGL
494-631: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-54: MAQTSSSSSSTFEHLWSSLEPDSTYFDLPQPSQGTSEASGSEESNMDVFHLQGM → MLYVGDPMRHLAT
394-489: Missing.
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketZ4YK94 | Z4YK94_MOUSE | Tumor protein p73 | Trp73 | 638 | Annotation score: | ||
G3UYS2 | G3UYS2_MOUSE | Cellular tumor antigen p53 | Trp73 | 367 | Annotation score: | ||
H3BK76 | H3BK76_MOUSE | Cellular tumor antigen p53 | Trp73 | 213 | Annotation score: | ||
B1AX91 | B1AX91_MOUSE | Transformation-related protein 73 | Trp73 | 204 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 118 | H → D in BAB30732 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 127 | S → G in BAE24089 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 254 | C → S in AAD32213 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 352 – 353 | RG → SAS in AAD32213 (PubMed:15489334).Curated | 2 | |
Sequence conflicti | 376 | P → H in AAD32213 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053081 | 1 – 54 | MAQTS…HLQGM → MLYVGDPMRHLAT in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST | 54 | |
Alternative sequenceiVSP_053082 | 394 – 489 | Missing in isoform 4. 1 PublicationAdd BLAST | 96 | |
Alternative sequenceiVSP_053083 | 489 – 493 | SFLTG → RTLGL in isoform 3. Curated | 5 | |
Alternative sequenceiVSP_053084 | 494 – 631 | Missing in isoform 3. CuratedAdd BLAST | 138 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y19234 mRNA Translation: CAB81953.1 Y19235 mRNA Translation: CAB81954.1 AK017412 mRNA Translation: BAB30732.1 AK139633 mRNA Translation: BAE24089.1 AL806525 Genomic DNA Translation: CAM18773.1 AL806525 Genomic DNA Translation: CAM18774.1 AL806525 Genomic DNA Translation: CAM18775.1 Different initiation. CH466594 Genomic DNA Translation: EDL14957.1 BC066045 mRNA Translation: AAH66045.1 AF138873 Genomic DNA Translation: AAD32213.1 |
CCDSi | CCDS19009.2 [Q9JJP2-1] CCDS51396.1 [Q9JJP2-4] CCDS51397.1 [Q9JJP2-2] |
RefSeqi | NP_001119802.1, NM_001126330.1 [Q9JJP2-2] NP_001119803.1, NM_001126331.1 [Q9JJP2-4] NP_035772.2, NM_011642.3 [Q9JJP2-1] |
Genome annotation databases
Ensembli | ENSMUST00000097762; ENSMUSP00000095368; ENSMUSG00000029026 [Q9JJP2-4] ENSMUST00000105643; ENSMUSP00000101268; ENSMUSG00000029026 [Q9JJP2-3] ENSMUST00000105644; ENSMUSP00000101269; ENSMUSG00000029026 [Q9JJP2-1] ENSMUST00000133533; ENSMUSP00000114418; ENSMUSG00000029026 [Q9JJP2-2] |
GeneIDi | 22062 |
KEGGi | mmu:22062 |
UCSCi | uc008wbg.2, mouse [Q9JJP2-2] uc012dqi.1, mouse [Q9JJP2-4] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y19234 mRNA Translation: CAB81953.1 Y19235 mRNA Translation: CAB81954.1 AK017412 mRNA Translation: BAB30732.1 AK139633 mRNA Translation: BAE24089.1 AL806525 Genomic DNA Translation: CAM18773.1 AL806525 Genomic DNA Translation: CAM18774.1 AL806525 Genomic DNA Translation: CAM18775.1 Different initiation. CH466594 Genomic DNA Translation: EDL14957.1 BC066045 mRNA Translation: AAH66045.1 AF138873 Genomic DNA Translation: AAD32213.1 |
CCDSi | CCDS19009.2 [Q9JJP2-1] CCDS51396.1 [Q9JJP2-4] CCDS51397.1 [Q9JJP2-2] |
RefSeqi | NP_001119802.1, NM_001126330.1 [Q9JJP2-2] NP_001119803.1, NM_001126331.1 [Q9JJP2-4] NP_035772.2, NM_011642.3 [Q9JJP2-1] |
3D structure databases
SMRi | Q9JJP2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204326, 5 interactors |
DIPi | DIP-41942N |
IntActi | Q9JJP2, 3 interactors |
MINTi | Q9JJP2 |
STRINGi | 10090.ENSMUSP00000101269 |
PTM databases
iPTMneti | Q9JJP2 |
PhosphoSitePlusi | Q9JJP2 |
Proteomic databases
PaxDbi | Q9JJP2 |
PRIDEi | Q9JJP2 |
Protocols and materials databases
Antibodypediai | 3467, 1100 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000097762; ENSMUSP00000095368; ENSMUSG00000029026 [Q9JJP2-4] ENSMUST00000105643; ENSMUSP00000101268; ENSMUSG00000029026 [Q9JJP2-3] ENSMUST00000105644; ENSMUSP00000101269; ENSMUSG00000029026 [Q9JJP2-1] ENSMUST00000133533; ENSMUSP00000114418; ENSMUSG00000029026 [Q9JJP2-2] |
GeneIDi | 22062 |
KEGGi | mmu:22062 |
UCSCi | uc008wbg.2, mouse [Q9JJP2-2] uc012dqi.1, mouse [Q9JJP2-4] |
Organism-specific databases
CTDi | 22062 |
MGIi | MGI:1336991, Trp73 |
Phylogenomic databases
eggNOGi | ENOG502QQ48, Eukaryota |
GeneTreei | ENSGT00950000183153 |
HOGENOMi | CLU_019621_1_1_1 |
InParanoidi | Q9JJP2 |
OMAi | FQHLWSS |
OrthoDBi | 257530at2759 |
PhylomeDBi | Q9JJP2 |
TreeFami | TF106101 |
Enzyme and pathway databases
Reactomei | R-MMU-6804759, Regulation of TP53 Activity through Association with Co-factors R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
Miscellaneous databases
BioGRID-ORCSi | 22062, 0 hits in 17 CRISPR screens |
ChiTaRSi | Trp73, mouse |
PROi | PR:Q9JJP2 |
RNActi | Q9JJP2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029026, Expressed in cerebral cortex and 96 other tissues |
ExpressionAtlasi | Q9JJP2, baseline and differential |
Genevisiblei | Q9JJP2, MM |
Family and domain databases
CDDi | cd08367, P53, 1 hit cd09571, SAM_tumor-p73, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.60.40.720, 1 hit 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR002117, p53_tumour_suppressor IPR001660, SAM IPR013761, SAM/pointed_sf IPR032646, Tp73 IPR037612, Tumour-p73_SAM |
PANTHERi | PTHR11447, PTHR11447, 1 hit PTHR11447:SF21, PTHR11447:SF21, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF07710, P53_tetramer, 1 hit PF07647, SAM_2, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47719, SSF47719, 1 hit SSF47769, SSF47769, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | P73_MOUSE | |
Accessioni | Q9JJP2Primary (citable) accession number: Q9JJP2 Secondary accession number(s): B1AX89 Q9WUJ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 14, 2009 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families