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Protein

Beta-catenin-interacting protein 1

Gene

Ctnnbip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.

GO - Molecular functioni

  • armadillo repeat domain binding Source: MGI
  • beta-catenin binding Source: MGI

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-catenin-interacting protein 1
Alternative name(s):
Inhibitor of beta-catenin and Tcf-4
Gene namesi
Name:Ctnnbip1
Synonyms:Catnbip1, Icat
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915756 Ctnnbip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi37 – 39EEE → AAA: Abolishes CTNNB1 binding. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001528831 – 81Beta-catenin-interacting protein 1Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JJN6
PaxDbiQ9JJN6
PeptideAtlasiQ9JJN6
PRIDEiQ9JJN6

PTM databases

iPTMnetiQ9JJN6
PhosphoSitePlusiQ9JJN6

Expressioni

Tissue specificityi

Highly expressed in heart, brain, liver and skeletal muscle. Detected at low levels in kidney, testis and lung.

Gene expression databases

BgeeiENSMUSG00000028988 Expressed in 283 organ(s), highest expression level in ear vesicle
CleanExiMM_CTNNBIP1
GenevisibleiQ9JJN6 MM

Interactioni

Subunit structurei

Binds CTNNB1.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211930, 3 interactors
ComplexPortaliCPX-86 Beta-catenin-ICAT complex
MINTiQ9JJN6
STRINGi10090.ENSMUSP00000030839

Structurei

3D structure databases

ProteinModelPortaliQ9JJN6
SMRiQ9JJN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CTNNBIP1 family.Curated

Phylogenomic databases

eggNOGiENOG410IYM5 Eukaryota
ENOG4111UJF LUCA
GeneTreeiENSGT00860000133817
HOGENOMiHOG000037432
HOVERGENiHBG051037
InParanoidiQ9JJN6
KOiK04493
OMAiHPIDQGA
OrthoDBiEOG091G0RZ1
PhylomeDBiQ9JJN6

Family and domain databases

Gene3Di1.10.10.490, 1 hit
InterProiView protein in InterPro
IPR009428 ICAT_dom
IPR036911 ICAT_sf
IPR040065 LZIC/CNBP1
PANTHERiPTHR16505 PTHR16505, 1 hit
PfamiView protein in Pfam
PF06384 ICAT, 1 hit
SUPFAMiSSF81730 SSF81730, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JJN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVSS
60 70 80
QLSQLPQHSI DQGAEDVVMA FSRSETEDRR Q
Length:81
Mass (Da):9,174
Last modified:October 1, 2000 - v1
Checksum:i2C58D060B50CE942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021261 mRNA Translation: BAB03457.1
AK003595 mRNA Translation: BAB22883.1
AK009066 mRNA Translation: BAB26052.1
AK036181 mRNA Translation: BAC29336.1
AK048258 mRNA Translation: BAC33287.1
BC038253 mRNA Translation: AAH38253.1
CCDSiCCDS38975.1
RefSeqiNP_001135402.1, NM_001141930.1
NP_075954.1, NM_023465.4
UniGeneiMm.299735
Mm.474667

Genome annotation databases

EnsembliENSMUST00000030839; ENSMUSP00000030839; ENSMUSG00000028988
ENSMUST00000105692; ENSMUSP00000101317; ENSMUSG00000028988
GeneIDi67087
KEGGimmu:67087
UCSCiuc008vwm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021261 mRNA Translation: BAB03457.1
AK003595 mRNA Translation: BAB22883.1
AK009066 mRNA Translation: BAB26052.1
AK036181 mRNA Translation: BAC29336.1
AK048258 mRNA Translation: BAC33287.1
BC038253 mRNA Translation: AAH38253.1
CCDSiCCDS38975.1
RefSeqiNP_001135402.1, NM_001141930.1
NP_075954.1, NM_023465.4
UniGeneiMm.299735
Mm.474667

3D structure databases

ProteinModelPortaliQ9JJN6
SMRiQ9JJN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211930, 3 interactors
ComplexPortaliCPX-86 Beta-catenin-ICAT complex
MINTiQ9JJN6
STRINGi10090.ENSMUSP00000030839

PTM databases

iPTMnetiQ9JJN6
PhosphoSitePlusiQ9JJN6

Proteomic databases

MaxQBiQ9JJN6
PaxDbiQ9JJN6
PeptideAtlasiQ9JJN6
PRIDEiQ9JJN6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030839; ENSMUSP00000030839; ENSMUSG00000028988
ENSMUST00000105692; ENSMUSP00000101317; ENSMUSG00000028988
GeneIDi67087
KEGGimmu:67087
UCSCiuc008vwm.2 mouse

Organism-specific databases

CTDi56998
MGIiMGI:1915756 Ctnnbip1

Phylogenomic databases

eggNOGiENOG410IYM5 Eukaryota
ENOG4111UJF LUCA
GeneTreeiENSGT00860000133817
HOGENOMiHOG000037432
HOVERGENiHBG051037
InParanoidiQ9JJN6
KOiK04493
OMAiHPIDQGA
OrthoDBiEOG091G0RZ1
PhylomeDBiQ9JJN6

Enzyme and pathway databases

ReactomeiR-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Miscellaneous databases

ChiTaRSiCtnnbip1 mouse
PROiPR:Q9JJN6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028988 Expressed in 283 organ(s), highest expression level in ear vesicle
CleanExiMM_CTNNBIP1
GenevisibleiQ9JJN6 MM

Family and domain databases

Gene3Di1.10.10.490, 1 hit
InterProiView protein in InterPro
IPR009428 ICAT_dom
IPR036911 ICAT_sf
IPR040065 LZIC/CNBP1
PANTHERiPTHR16505 PTHR16505, 1 hit
PfamiView protein in Pfam
PF06384 ICAT, 1 hit
SUPFAMiSSF81730 SSF81730, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNBP1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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