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Protein

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Gene

Herpud1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUnfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
Gene namesi
Name:Herpud1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1927406 Herpud1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 263CytoplasmicSequence analysisAdd BLAST263
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 289LumenalSequence analysis5
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 391CytoplasmicSequence analysisAdd BLAST81

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149211 – 391Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 proteinAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei135PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9JJK5
MaxQBiQ9JJK5
PaxDbiQ9JJK5
PRIDEiQ9JJK5

PTM databases

iPTMnetiQ9JJK5
PhosphoSitePlusiQ9JJK5

Expressioni

Gene expression databases

BgeeiENSMUSG00000031770 Expressed in 291 organ(s), highest expression level in lacrimal gland
ExpressionAtlasiQ9JJK5 baseline and differential
GenevisibleiQ9JJK5 MM

Interactioni

Subunit structurei

Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6. Interacts with UBQLN1, UBQLN2 and UBQLN4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211038, 3 interactors
STRINGi10090.ENSMUSP00000124201

Structurei

3D structure databases

ProteinModelPortaliQ9JJK5
SMRiQ9JJK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 72Ubiquitin-likePROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 200Interaction with UBQLN1By similarityAdd BLAST86

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4583 Eukaryota
ENOG410ZJAF LUCA
GeneTreeiENSGT00390000017671
HOGENOMiHOG000252989
HOVERGENiHBG051899
InParanoidiQ9JJK5
KOiK14027
OMAiANQNMRM
OrthoDBiEOG091G0P9J
TreeFamiTF324319

Family and domain databases

InterProiView protein in InterPro
IPR039751 HERPUD1/2
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR12943 PTHR12943, 1 hit
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9JJK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPEPQPEPV TLLVKSPNQR HRDLELSGDR SWSVSRLKAH LSRVYPERPR
60 70 80 90 100
PEDQRLIYSG KLLLDHQCLQ DLLPKQEKRH VLHLVCNVKN PSKMPETSTK
110 120 130 140 150
GAESTEQPDN SNQTQHPGDS SSDGLRQREV LRNLSPSGWE NISRPEAVQQ
160 170 180 190 200
TFQGLGPGFS GYTTYGWLQL SWFQQIYARQ YYMQYLAATA ASGTFVPTPS
210 220 230 240 250
AQEIPVVSTP APAPIHNQFP AENQPANQNA AAQAVVNPGA NQNLRMNAQG
260 270 280 290 300
GPLVEEDDEI NRDWLDWTYS AATFSVFLSI LYFYSSLSRF LMVMGATVVM
310 320 330 340 350
YLHHVGWFPF RQRPVQNFPD DGGPRDAANQ DPNNNLQGGM DPEMEDPNRL
360 370 380 390
PPDREVLDPE HTSPSFMSTA WLVFKTFFAS LLPEGPPALA N
Length:391
Mass (Da):43,907
Last modified:October 1, 2000 - v1
Checksum:i7F707DBF9B1A3A12
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8C4N0Q8C4N0_MOUSE
Homocysteine-responsive endoplasmic...
Herpud1
390Annotation score:
A0A1D5RM09A0A1D5RM09_MOUSE
Homocysteine-responsive endoplasmic...
Herpud1
179Annotation score:
A0A1D5RLM1A0A1D5RLM1_MOUSE
Homocysteine-responsive endoplasmic...
Herpud1
62Annotation score:
A0A1D5RMG9A0A1D5RMG9_MOUSE
Homocysteine-responsive endoplasmic...
Herpud1
36Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034991 mRNA Translation: BAB07892.1
CCDSiCCDS22541.1
RefSeqiNP_071726.1, NM_022331.1
UniGeneiMm.29151

Genome annotation databases

EnsembliENSMUST00000161576; ENSMUSP00000124201; ENSMUSG00000031770
GeneIDi64209
KEGGimmu:64209
UCSCiuc009mwg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034991 mRNA Translation: BAB07892.1
CCDSiCCDS22541.1
RefSeqiNP_071726.1, NM_022331.1
UniGeneiMm.29151

3D structure databases

ProteinModelPortaliQ9JJK5
SMRiQ9JJK5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211038, 3 interactors
STRINGi10090.ENSMUSP00000124201

PTM databases

iPTMnetiQ9JJK5
PhosphoSitePlusiQ9JJK5

Proteomic databases

EPDiQ9JJK5
MaxQBiQ9JJK5
PaxDbiQ9JJK5
PRIDEiQ9JJK5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000161576; ENSMUSP00000124201; ENSMUSG00000031770
GeneIDi64209
KEGGimmu:64209
UCSCiuc009mwg.1 mouse

Organism-specific databases

CTDi9709
MGIiMGI:1927406 Herpud1

Phylogenomic databases

eggNOGiKOG4583 Eukaryota
ENOG410ZJAF LUCA
GeneTreeiENSGT00390000017671
HOGENOMiHOG000252989
HOVERGENiHBG051899
InParanoidiQ9JJK5
KOiK14027
OMAiANQNMRM
OrthoDBiEOG091G0P9J
TreeFamiTF324319

Miscellaneous databases

ChiTaRSiHerpud1 mouse
PROiPR:Q9JJK5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031770 Expressed in 291 organ(s), highest expression level in lacrimal gland
ExpressionAtlasiQ9JJK5 baseline and differential
GenevisibleiQ9JJK5 MM

Family and domain databases

InterProiView protein in InterPro
IPR039751 HERPUD1/2
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR12943 PTHR12943, 1 hit
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHERP1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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