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Protein

LanC-like protein 2

Gene

Lancl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
LanC-like protein 2
Alternative name(s):
Testis-specific adriamycin sensitivity protein
Gene namesi
Name:Lancl2
Synonyms:Tasp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1919085 Lancl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001912732 – 450LanC-like protein 2Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei198PhosphotyrosineCombined sources1

Post-translational modificationi

Myristoylated. Essential for membrane association.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9JJK2
MaxQBiQ9JJK2
PaxDbiQ9JJK2
PRIDEiQ9JJK2

PTM databases

iPTMnetiQ9JJK2
PhosphoSitePlusiQ9JJK2
SwissPalmiQ9JJK2

Expressioni

Gene expression databases

BgeeiENSMUSG00000062190
ExpressionAtlasiQ9JJK2 baseline and differential
GenevisibleiQ9JJK2 MM

Interactioni

Subunit structurei

Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association.By similarity

Protein-protein interaction databases

BioGridi214964, 2 interactors
IntActiQ9JJK2, 4 interactors
MINTiQ9JJK2
STRINGi10090.ENSMUSP00000052146

Structurei

3D structure databases

ProteinModelPortaliQ9JJK2
SMRiQ9JJK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 14Interaction with inositol phospholipidsBy similarityAdd BLAST13

Sequence similaritiesi

Belongs to the LanC-like protein family.Curated

Phylogenomic databases

eggNOGiKOG2787 Eukaryota
ENOG410XQIA LUCA
GeneTreeiENSGT00530000063186
HOGENOMiHOG000240926
HOVERGENiHBG065387
InParanoidiQ9JJK2
OMAiMEERAFA
PhylomeDBiQ9JJK2
TreeFamiTF300068

Family and domain databases

CDDicd04794 euk_LANCL, 1 hit
Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR007822 LANC-like
IPR020464 LanC-like_prot_euk
PfamiView protein in Pfam
PF05147 LANC_like, 1 hit
PRINTSiPR01951 LANCEUKARYTE
PR01950 LANCSUPER
SMARTiView protein in SMART
SM01260 LANC_like, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGETMSKRLK FHLGEAEMEE RSFPNPFPDY EAAASAAGLA AGSAEETGRV
60 70 80 90 100
CPLPTTEDPG LPFHPNGKIV PNFIKRIQTK IKDLLQQMEE GLKTADPHDC
110 120 130 140 150
SAYTGWTGIA LLYLQLYRVT GDQTYLLRSL DYVKRTLRNL SGRRVTFLCG
160 170 180 190 200
DAGPLAVGAV IYHKLKSECE SQECITKLLQ MHRTIVCQES ELPDELLYGR
210 220 230 240 250
AGYLYALLYL NTEIGPGTVG ETAIKEVVSA IIESGKSLSR EERKSERCPL
260 270 280 290 300
LYQWHRKQYV GAAHGMAGIY YMLMQPEAKV DQETLTEMVK PSIDYVRHKK
310 320 330 340 350
FRSGNYPSSL SNETDRLVHW CHGAPGVIHV LLQAYQVFKE EKYLKEAMEC
360 370 380 390 400
SDVIWQRGLL RKGYGICHGT SGNGYSFLSL YRLTQDKKYL YRACKFAEWC
410 420 430 440 450
LDYGAHGCRI PDRPYSLFEG MAGAVHFLSD ILVPETARFP AFELGFLQKD
Length:450
Mass (Da):50,777
Last modified:October 1, 2000 - v1
Checksum:i854EF4684C34643F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035967 mRNA Translation: BAA96801.1
BC016072 mRNA Translation: AAH16072.1
CCDSiCCDS20185.1
RefSeqiNP_598498.1, NM_133737.2
UniGeneiMm.274904

Genome annotation databases

EnsembliENSMUST00000050077; ENSMUSP00000052146; ENSMUSG00000062190
ENSMUST00000072954; ENSMUSP00000072723; ENSMUSG00000062190
GeneIDi71835
KEGGimmu:71835
UCSCiuc009ccn.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLANC2_MOUSE
AccessioniPrimary (citable) accession number: Q9JJK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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