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Entry version 130 (10 Feb 2021)
Sequence version 1 (01 Oct 2000)
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Protein

Protein-serine O-palmitoleoyltransferase porcupine

Gene

Porcn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors.5 Publications

Caution

Was initially thought to mediate palmitoylation of Wnt proteins. It was later shown that it instead acts as a serine O-palmitoleoyltransferase that mediates the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins (PubMed:17141155, PubMed:24798332).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3411 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • O-acyltransferase activity Source: Reactome
  • palmitoleoyltransferase activity Source: UniProtKB
  • transferase activity, transferring acyl groups Source: GO_Central
  • Wnt-protein binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processWnt signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-serine O-palmitoleoyltransferase porcupineCurated (EC:2.3.1.2502 Publications)
Short name:
mPORC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PorcnImported
Synonyms:Porc, Ppn
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1890212, Porcn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 66ExtracellularSequence analysisAdd BLAST28
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88 – 95CytoplasmicSequence analysis8
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 152ExtracellularSequence analysisAdd BLAST36
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 198CytoplasmicSequence analysisAdd BLAST25
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 252ExtracellularSequence analysisAdd BLAST33
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Topological domaini274 – 337CytoplasmicSequence analysisAdd BLAST64
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Topological domaini359 – 396ExtracellularSequence analysisAdd BLAST38
Transmembranei397 – 417HelicalSequence analysisAdd BLAST21
Topological domaini418 – 461CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi136S → F: Impaired acyltransferase activity. 1 Publication1
Mutagenesisi172S → A: Does not affect acyltransferase activity. 1 Publication1
Mutagenesisi228R → C: Does not affect acyltransferase activity. 1 Publication1
Mutagenesisi305W → A: Impaired acyltransferase activity. 1 Publication1
Mutagenesisi306N → A: Does not affect acyltransferase activity. 1 Publication1
Mutagenesisi312W → A: Does not affect acyltransferase activity. 1 Publication1
Mutagenesisi316Y → A: Impaired acyltransferase activity. 1 Publication1
Mutagenesisi331L → R: Impaired acyltransferase activity. 1 Publication1
Mutagenesisi334Y → A: Impaired acyltransferase activity. Impaired ability to interact with WNT3A. 1 Publication1
Mutagenesisi337S → A: Abolished acyltransferase activity. Impaired ability to interact with WNT3A. 1 Publication1
Mutagenesisi340L → A: Abolished acyltransferase activity. 1 Publication1
Mutagenesisi341H → A: Abolished acyltransferase activity. Impaired ability to interact with WNT3A. 1 Publication1
Mutagenesisi365R → Q: Impaired acyltransferase activity. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1255164

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002131381 – 461Protein-serine O-palmitoleoyltransferase porcupineAdd BLAST461

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JJJ7

PRoteomics IDEntifications database

More...
PRIDEi
Q9JJJ7

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JJJ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, heart, kidney, liver, lung, muscle, spleen and testis. Isoform 4 is strongly expressed in kidney, liver, lung, spleen and testis. Isoform 1 is strongly expressed in brain, heart and muscle and poorly in kidney, liver, lung, spleen and testis.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed at different levels in embryo at 9.5, 10.5, 11.5, 12.5, 13.5 and 15.5 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031169, Expressed in cerebellar cortex and 188 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9JJJ7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JJJ7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WNT1, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A and WNT7B.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
207344, 9 interactors

Protein interaction database and analysis system

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IntActi
Q9JJJ7, 7 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000076790

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9JJJ7

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9JJJ7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4312, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01010000222502

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_048745_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JJJ7

Identification of Orthologs from Complete Genome Data

More...
OMAi
IEWPRSI

Database of Orthologous Groups

More...
OrthoDBi
975725at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JJJ7

TreeFam database of animal gene trees

More...
TreeFami
TF313724

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004299, MBOAT_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03062, MBOAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JJJ7-1) [UniParc]FASTAAdd to basket
Also known as: D

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATFSRQEFF QQLLQGCLLP TVQQGLDQIW LLLTICFACR LLWRLGLPSY
60 70 80 90 100
LKHASTVAGG FFSLYHFFQL HMVWVVLLSL LCYLVLFLCR HSSHRGVFLS
110 120 130 140 150
VTILIYLLMG EMHMVDTVTW HKMRGAQMIV AMKAVSLGFD LDRGEVGAVP
160 170 180 190 200
SPVEFMGYLY FVGTIVFGPW ISFHSYLQAV QGRPLSRRWL KKVARSLALA
210 220 230 240 250
LLCLVLSTCV GPYLFPYFIP LDGDRLLRNK KRKARGTMVR WLRAYESAVS
260 270 280 290 300
FHFSNYFVGF LSEATATLAG AGFTEEKDHL EWDLTVSRPL NVELPRSMVE
310 320 330 340 350
VVTSWNLPMS YWLNNYVFKN ALRLGTFSAV LVTYAASALL HGFSFHLAAV
360 370 380 390 400
LLSLAFITYV EHVLRKRLAQ ILSACILSKR CLPDCSHRHR LGLGVRALNL
410 420 430 440 450
LFGALAIFHL SYLGSLFDVD VDDTTEEQGY GMAYTVHKWS ELSWASHWVT
460
FGCWIFYRLI G
Length:461
Mass (Da):52,508
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25A52681C251A0A6
GO
Isoform 2 (identifier: Q9JJJ7-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     235-239: Missing.

Show »
Length:456
Mass (Da):51,963
Checksum:i2903AD4BD0CA2184
GO
Isoform 3 (identifier: Q9JJJ7-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     229-235: NKKRKAR → K

Show »
Length:455
Mass (Da):51,754
Checksum:iA78DCC9613A18319
GO
Isoform 4 (identifier: Q9JJJ7-4) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     229-240: NKKRKARGTMVR → K

Show »
Length:450
Mass (Da):51,209
Checksum:i992012ABE6B649E8
GO
Isoform 5 (identifier: Q9JJJ7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     235-239: RGTMV → MAQDA

Show »
Length:227
Mass (Da):25,726
Checksum:i4B78150917A1685B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2F8S4R2F8_MOUSE
Protein-serine O-palmitoleoyltransf...
Porcn
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2I7S4R2I7_MOUSE
Protein-serine O-palmitoleoyltransf...
Porcn
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0158891 – 234Missing in isoform 5. 1 PublicationAdd BLAST234
Alternative sequenceiVSP_015890229 – 240NKKRK…GTMVR → K in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_015891229 – 235NKKRKAR → K in isoform 3. 2 Publications7
Alternative sequenceiVSP_015892235 – 239Missing in isoform 2. 1 Publication5
Alternative sequenceiVSP_015893235 – 239RGTMV → MAQDA in isoform 5. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB036746 mRNA Translation: BAA89467.1
AB036747 mRNA Translation: BAA89468.1
AB036748 mRNA Translation: BAA89469.1
AB036749 mRNA Translation: BAA89470.1
AK010405 mRNA Translation: BAB26914.1
AL663032 Genomic DNA No translation available.
BC032284 mRNA Translation: AAH32284.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29990.1 [Q9JJJ7-4]
CCDS29991.1 [Q9JJJ7-1]
CCDS29992.1 [Q9JJJ7-3]
CCDS29993.1 [Q9JJJ7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001295403.1, NM_001308474.1 [Q9JJJ7-5]
NP_058609.1, NM_016913.4 [Q9JJJ7-4]
NP_076127.1, NM_023638.4 [Q9JJJ7-1]
NP_665914.1, NM_145907.4 [Q9JJJ7-3]
NP_665915.1, NM_145908.4 [Q9JJJ7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000077595; ENSMUSP00000076790; ENSMUSG00000031169 [Q9JJJ7-1]
ENSMUST00000082320; ENSMUSP00000080937; ENSMUSG00000031169 [Q9JJJ7-2]
ENSMUST00000089402; ENSMUSP00000086824; ENSMUSG00000031169 [Q9JJJ7-4]
ENSMUST00000089403; ENSMUSP00000086825; ENSMUSG00000031169 [Q9JJJ7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
53627

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:53627

UCSC genome browser

More...
UCSCi
uc009soj.2, mouse [Q9JJJ7-1]
uc009sok.2, mouse [Q9JJJ7-2]
uc009sol.2, mouse [Q9JJJ7-3]
uc009som.2, mouse [Q9JJJ7-4]
uc012heo.1, mouse [Q9JJJ7-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036746 mRNA Translation: BAA89467.1
AB036747 mRNA Translation: BAA89468.1
AB036748 mRNA Translation: BAA89469.1
AB036749 mRNA Translation: BAA89470.1
AK010405 mRNA Translation: BAB26914.1
AL663032 Genomic DNA No translation available.
BC032284 mRNA Translation: AAH32284.1
CCDSiCCDS29990.1 [Q9JJJ7-4]
CCDS29991.1 [Q9JJJ7-1]
CCDS29992.1 [Q9JJJ7-3]
CCDS29993.1 [Q9JJJ7-2]
RefSeqiNP_001295403.1, NM_001308474.1 [Q9JJJ7-5]
NP_058609.1, NM_016913.4 [Q9JJJ7-4]
NP_076127.1, NM_023638.4 [Q9JJJ7-1]
NP_665914.1, NM_145907.4 [Q9JJJ7-3]
NP_665915.1, NM_145908.4 [Q9JJJ7-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi207344, 9 interactors
IntActiQ9JJJ7, 7 interactors
STRINGi10090.ENSMUSP00000076790

Chemistry databases

BindingDBiQ9JJJ7
ChEMBLiCHEMBL1255164

PTM databases

PhosphoSitePlusiQ9JJJ7

Proteomic databases

PaxDbiQ9JJJ7
PRIDEiQ9JJJ7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
25667, 102 antibodies

Genome annotation databases

EnsembliENSMUST00000077595; ENSMUSP00000076790; ENSMUSG00000031169 [Q9JJJ7-1]
ENSMUST00000082320; ENSMUSP00000080937; ENSMUSG00000031169 [Q9JJJ7-2]
ENSMUST00000089402; ENSMUSP00000086824; ENSMUSG00000031169 [Q9JJJ7-4]
ENSMUST00000089403; ENSMUSP00000086825; ENSMUSG00000031169 [Q9JJJ7-3]
GeneIDi53627
KEGGimmu:53627
UCSCiuc009soj.2, mouse [Q9JJJ7-1]
uc009sok.2, mouse [Q9JJJ7-2]
uc009sol.2, mouse [Q9JJJ7-3]
uc009som.2, mouse [Q9JJJ7-4]
uc012heo.1, mouse [Q9JJJ7-5]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64840
MGIiMGI:1890212, Porcn

Phylogenomic databases

eggNOGiKOG4312, Eukaryota
GeneTreeiENSGT01010000222502
HOGENOMiCLU_048745_0_0_1
InParanoidiQ9JJJ7
OMAiIEWPRSI
OrthoDBi975725at2759
PhylomeDBiQ9JJJ7
TreeFamiTF313724

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
53627, 0 hits in 17 CRISPR screens

Protein Ontology

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PROi
PR:Q9JJJ7
RNActiQ9JJJ7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031169, Expressed in cerebellar cortex and 188 other tissues
ExpressionAtlasiQ9JJJ7, baseline and differential
GenevisibleiQ9JJJ7, MM

Family and domain databases

InterProiView protein in InterPro
IPR004299, MBOAT_fam
PfamiView protein in Pfam
PF03062, MBOAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPORCN_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JJJ7
Secondary accession number(s): A2AC30
, A2AC32, A2AC33, Q9CWT0, Q9JJJ8, Q9JJJ9, Q9JJK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2000
Last modified: February 10, 2021
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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