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Protein

Neuromedin-U receptor 1

Gene

Nmur1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 1
Short name:
NMU-R1
Alternative name(s):
G-protein coupled receptor 66
G-protein coupled receptor FM-3
Gene namesi
Name:Nmur1
Synonyms:Gpr66
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619867 Nmur1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 59ExtracellularSequence analysisAdd BLAST59
Transmembranei60 – 80Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini81 – 96CytoplasmicSequence analysisAdd BLAST16
Transmembranei97 – 117Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini118 – 137ExtracellularSequence analysisAdd BLAST20
Transmembranei138 – 158Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini159 – 181CytoplasmicSequence analysisAdd BLAST23
Transmembranei182 – 202Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini203 – 235ExtracellularSequence analysisAdd BLAST33
Transmembranei236 – 256Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini257 – 294CytoplasmicSequence analysisAdd BLAST38
Transmembranei295 – 315Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini316 – 331ExtracellularSequence analysisAdd BLAST16
Transmembranei332 – 352Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini353 – 425CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699081 – 425Neuromedin-U receptor 1Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi134 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JJI5
PRIDEiQ9JJI5

PTM databases

PhosphoSitePlusiQ9JJI5

Expressioni

Tissue specificityi

Highly expressed in the small intestine and lung. Low expression in the central nervous system.1 Publication

Gene expression databases

BgeeiENSRNOG00000018521

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025024

Structurei

3D structure databases

ProteinModelPortaliQ9JJI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000113804
HOVERGENiHBG103506
InParanoidiQ9JJI5
OrthoDBiEOG091G0ZDG
TreeFamiTF318522

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005390 NeuromedU_rcpt
IPR005391 NeuromedU_rcpt_1
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01565 NEUROMEDINUR
PR01566 NEUROMEDNU1R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JJI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPCLNCSF FPGQLSPNAS TGLLSCNDSE FKEHFDLEDL NLTHEDLRLK
60 70 80 90 100
YLGPQQVKQF LPICVTYLLI FVVGTLGNGL TCTVILRQKA MHTPTNFYLF
110 120 130 140 150
SLAVSDLLVL LVGLPLELYE MQHNYPFQLG AGGCYFRILL LETVCLASVL
160 170 180 190 200
NVTALSVERY VAVVHPLQAK SVMTRTHVRR MLGAIWVFAI LFSLPNTSLH
210 220 230 240 250
GLSPLYVPCR GPVPDSVTCT LVRPQFFYKL VIQTTILLFF CLPMVTISVL
260 270 280 290 300
YLLIGLRLRR ERILLQEEVK GRISAAARQA SHRSIQLRDR ERRQVTKMLI
310 320 330 340 350
ALVIVFGTCW VPFHADRLMW SMVSHWTDGL RLAFQSVHLA SGVFLYLGSA
360 370 380 390 400
ANPVLYNLMS TRFRESFRET LGLGTRCCHR HQPRHDSHSH LRLTTVSTLC
410 420
DRNSRDVPLA ENRDPGCEQE TDPPE
Length:425
Mass (Da):48,129
Last modified:March 16, 2016 - v2
Checksum:i16DD0173D5DBB23E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14Q → M in BAA99387 (PubMed:10783389).Curated1
Sequence conflicti263I → M in BAA99387 (PubMed:10783389).Curated1
Sequence conflicti354V → E in BAA99387 (PubMed:10783389).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112440 Genomic DNA No translation available.
AB038649 mRNA Translation: BAA99387.1
AF242873 mRNA Translation: AAF82754.1
UniGeneiRn.54457

Genome annotation databases

UCSCiRGD:619867 rat

Similar proteinsi

Entry informationi

Entry nameiNMUR1_RAT
AccessioniPrimary (citable) accession number: Q9JJI5
Secondary accession number(s): F1LQC9, Q9JIB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 16, 2016
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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