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Entry version 123 (26 Feb 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Transient receptor potential cation channel subfamily M member 5

Gene

Trpm5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-modulated Ca2+-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na+, K+ and Cs+ ions equally well. Activated directly by increases in intracellular Ca2+, but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca2+. Also activated by a fast intracellular Ca2+ increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Phosphatidylinositol 4,5-bisphosphate (PIP2) is able to partially restore sensitivity to Ca2+ after desensitization. Inhibited by flufenamic acid with an IC50 of 24.5 µM and spermine with an IC50 of 37 µM.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor, Voltage-gated channel
Biological processIon transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3295583 TRP channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 5
Alternative name(s):
Long transient receptor potential channel 5
Short name:
LTrpC-5
Short name:
LTrpC5
MLSN1- and TRP-related gene 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Trpm5Imported
Synonyms:Ltrpc5Imported, Mtr1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1861718 Trpm5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 645CytoplasmicSequence analysisAdd BLAST645
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei646 – 666HelicalSequence analysisAdd BLAST21
Topological domaini667 – 732ExtracellularSequence analysisAdd BLAST66
Transmembranei733 – 753HelicalSequence analysisAdd BLAST21
Topological domaini754 – 810CytoplasmicSequence analysisAdd BLAST57
Transmembranei811 – 831HelicalSequence analysisAdd BLAST21
Topological domaini832 – 834ExtracellularSequence analysis3
Transmembranei835 – 855HelicalSequence analysisAdd BLAST21
Topological domaini856 – 871CytoplasmicSequence analysisAdd BLAST16
Transmembranei872 – 892HelicalSequence analysisAdd BLAST21
Topological domaini893 – 953ExtracellularSequence analysisAdd BLAST61
Transmembranei954 – 974HelicalSequence analysisAdd BLAST21
Topological domaini975 – 1158CytoplasmicSequence analysisAdd BLAST184

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show diminished behavioral and nerve responses to bitter, sweet and umami tastes.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi831E → Q: Reduces sensitivity to block by extracellular acidification. Sensitivity to block by low extracellular pH is nearly abolished; when associated with N-935. 1 Publication1
Mutagenesisi897H → N: Shows normal sensitivity to acid block and significant recovery from acid-enhanced inactivation. 1 Publication1
Mutagenesisi935H → N: Reduces sensitivity to block by extracellular acidification. Sensitivity to block by low extracellular pH is nearly abolished; when associated with Q-831. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3886124

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
497

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003289341 – 1158Transient receptor potential cation channel subfamily M member 5Add BLAST1158

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JJH7

PRoteomics IDEntifications database

More...
PRIDEi
Q9JJH7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JJH7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JJH7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in liver, heart, testis, brain and kidney. Detected in fetal liver, kidney, spleen, brain, heart and lung, and in adult skin, eyes, spleen, stomach, small intestine, colon, lung, bladder, pancreas and thymus. Biallelically expressed at all stages and tissues examined. Also expressed in subsets of taste receptor cells of the tongue, in olfactory sensory neurons of the main olfactory epithelium and in the vomeronasal organ.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000009246 Expressed in islet of Langerhans and 105 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9JJH7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JJH7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000009390

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9JJH7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JJH7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili552 – 572Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3614 Eukaryota
ENOG410XR5B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160588

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001390_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JJH7

KEGG Orthology (KO)

More...
KOi
K04980

Identification of Orthologs from Complete Genome Data

More...
OMAi
SRVEWIF

Database of Orthologous Groups

More...
OrthoDBi
738147at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JJH7

TreeFam database of animal gene trees

More...
TreeFami
TF314204

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR029577 TRPM5
IPR041491 TRPM_SLOG

The PANTHER Classification System

More...
PANTHERi
PTHR13800:SF5 PTHR13800:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 1 hit
PF18139 LSDAT_euk, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 16 Publications (identifier: Q9JJH7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQTTQSSCPG SPPDTEDGWE PILCRGEINF GGSGKKRGKF VKVPSSVAPS
60 70 80 90 100
VLFELLLTEW HLPAPNLVVS LVGEERPLAM KSWLRDVLRK GLVKAAQSTG
110 120 130 140 150
AWILTSALHV GLARHVGQAV RDHSLASTST KIRVVAIGMA SLDRILHRQL
160 170 180 190 200
LDGVHQKEDT PIHYPADEGN IQGPLCPLDS NLSHFILVES GALGSGNDGL
210 220 230 240 250
TELQLSLEKH ISQQRTGYGG TSCIQIPVLC LLVNGDPNTL ERISRAVEQA
260 270 280 290 300
APWLILAGSG GIADVLAALV SQPHLLVPQV AEKQFREKFP SECFSWEAIV
310 320 330 340 350
HWTELLQNIA AHPHLLTVYD FEQEGSEDLD TVILKALVKA CKSHSQEAQD
360 370 380 390 400
YLDELKLAVA WDRVDIAKSE IFNGDVEWKS CDLEEVMTDA LVSNKPDFVR
410 420 430 440 450
LFVDSGADMA EFLTYGRLQQ LYHSVSPKSL LFELLQRKHE EGRLTLAGLG
460 470 480 490 500
AQQARELPIG LPAFSLHEVS RVLKDFLHDA CRGFYQDGRR MEERGPPKRP
510 520 530 540 550
AGQKWLPDLS RKSEDPWRDL FLWAVLQNRY EMATYFWAMG REGVAAALAA
560 570 580 590 600
CKIIKEMSHL EKEAEVARTM REAKYEQLAL DLFSECYGNS EDRAFALLVR
610 620 630 640 650
RNHSWSRTTC LHLATEADAK AFFAHDGVQA FLTKIWWGDM ATGTPILRLL
660 670 680 690 700
GAFTCPALIY TNLISFSEDA PQRMDLEDLQ EPDSLDMEKS FLCSRGGQLE
710 720 730 740 750
KLTEAPRAPG DLGPQAAFLL TRWRKFWGAP VTVFLGNVVM YFAFLFLFTY
760 770 780 790 800
VLLVDFRPPP QGPSGSEVTL YFWVFTLVLE EIRQGFFTDE DTHLVKKFTL
810 820 830 840 850
YVEDNWNKCD MVAIFLFIVG VTCRMVPSVF EAGRTVLAID FMVFTLRLIH
860 870 880 890 900
IFAIHKQLGP KIIIVERMMK DVFFFLFFLS VWLVAYGVTT QALLHPHDGR
910 920 930 940 950
LEWIFRRVLY RPYLQIFGQI PLDEIDEARV NCSLHPLLLE SSASCPNLYA
960 970 980 990 1000
NWLVILLLVT FLLVTNVLLM NLLIAMFSYT FQVVQGNADM FWKFQRYHLI
1010 1020 1030 1040 1050
VEYHGRPALA PPFILLSHLS LVLKQVFRKE AQHKRQHLER DLPDPLDQKI
1060 1070 1080 1090 1100
ITWETVQKEN FLSTMEKRRR DSEGEVLRKT AHRVDLIAKY IGGLREQEKR
1110 1120 1130 1140 1150
IKCLESQANY CMLLLSSMTD TLAPGGTYSS SQNCGCRSQP ASARDREYLE

SGLPPSDT
Length:1,158
Mass (Da):130,844
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0A5237EC67867CE
GO
Isoform 21 Publication (identifier: Q9JJH7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1108-1116: ANYCMLLLS → SKYGFRPWE
     1117-1158: Missing.

Show »
Length:1,116
Mass (Da):126,609
Checksum:i32DFFABCF2835E48
GO
Isoform 31 Publication (identifier: Q9JJH7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     978-1000: SYTFQVVQGNADMFWKFQRYHLI → RVLTETGPMSWYFAAVSSGLDLQ
     1001-1158: Missing.

Show »
Length:1,000
Mass (Da):112,460
Checksum:iBB107610176E6660
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RUN7F6RUN7_MOUSE
Transient receptor potential cation...
Trpm5
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CCW2F7CCW2_MOUSE
Transient receptor potential cation...
Trpm5
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB94717 differs from that shown. Reason: Frameshift.Curated
The sequence CAC19456 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24C → S in AAI33713 (PubMed:15489334).Curated1
Sequence conflicti612H → P in CAB94717 (PubMed:10915772).Curated1
Sequence conflicti871D → E in BAE36157 (PubMed:16141072).Curated1
Sequence conflicti897H → N in AAI33713 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052744978 – 1000SYTFQ…RYHLI → RVLTETGPMSWYFAAVSSGL DLQ in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0527451001 – 1158Missing in isoform 3. 1 PublicationAdd BLAST158
Alternative sequenceiVSP_0527461108 – 1116ANYCMLLLS → SKYGFRPWE in isoform 2. 1 Publication9
Alternative sequenceiVSP_0527471117 – 1158Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB039952 mRNA Translation: BAA96877.1
AF228681 mRNA Translation: AAF98120.1
AJ251835 Genomic DNA Translation: CAC19456.1 Frameshift.
AJ251835 Genomic DNA Translation: CAC19457.1
AJ271092 mRNA Translation: CAB94717.2 Frameshift.
AY280364 mRNA Translation: AAP44476.1
AY280365 mRNA Translation: AAP44477.1
BC133712 mRNA Translation: AAI33713.1
AK161030 mRNA Translation: BAE36157.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52462.1 [Q9JJH7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_064673.2, NM_020277.2 [Q9JJH7-1]
XP_006508708.1, XM_006508645.1 [Q9JJH7-1]
XP_006508709.1, XM_006508646.3 [Q9JJH7-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000009390; ENSMUSP00000009390; ENSMUSG00000009246 [Q9JJH7-1]
ENSMUST00000150867; ENSMUSP00000114302; ENSMUSG00000009246 [Q9JJH7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56843

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:56843

UCSC genome browser

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UCSCi
uc009koz.1 mouse [Q9JJH7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039952 mRNA Translation: BAA96877.1
AF228681 mRNA Translation: AAF98120.1
AJ251835 Genomic DNA Translation: CAC19456.1 Frameshift.
AJ251835 Genomic DNA Translation: CAC19457.1
AJ271092 mRNA Translation: CAB94717.2 Frameshift.
AY280364 mRNA Translation: AAP44476.1
AY280365 mRNA Translation: AAP44477.1
BC133712 mRNA Translation: AAI33713.1
AK161030 mRNA Translation: BAE36157.1
CCDSiCCDS52462.1 [Q9JJH7-1]
RefSeqiNP_064673.2, NM_020277.2 [Q9JJH7-1]
XP_006508708.1, XM_006508645.1 [Q9JJH7-1]
XP_006508709.1, XM_006508646.3 [Q9JJH7-3]

3D structure databases

SMRiQ9JJH7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009390

Chemistry databases

ChEMBLiCHEMBL3886124
GuidetoPHARMACOLOGYi497

PTM databases

iPTMnetiQ9JJH7
PhosphoSitePlusiQ9JJH7

Proteomic databases

PaxDbiQ9JJH7
PRIDEiQ9JJH7

Genome annotation databases

EnsembliENSMUST00000009390; ENSMUSP00000009390; ENSMUSG00000009246 [Q9JJH7-1]
ENSMUST00000150867; ENSMUSP00000114302; ENSMUSG00000009246 [Q9JJH7-3]
GeneIDi56843
KEGGimmu:56843
UCSCiuc009koz.1 mouse [Q9JJH7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29850
MGIiMGI:1861718 Trpm5

Phylogenomic databases

eggNOGiKOG3614 Eukaryota
ENOG410XR5B LUCA
GeneTreeiENSGT00940000160588
HOGENOMiCLU_001390_0_1_1
InParanoidiQ9JJH7
KOiK04980
OMAiSRVEWIF
OrthoDBi738147at2759
PhylomeDBiQ9JJH7
TreeFamiTF314204

Enzyme and pathway databases

ReactomeiR-MMU-3295583 TRP channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Trpm5 mouse

Protein Ontology

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PROi
PR:Q9JJH7
RNActiQ9JJH7 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000009246 Expressed in islet of Langerhans and 105 other tissues
ExpressionAtlasiQ9JJH7 baseline and differential
GenevisibleiQ9JJH7 MM

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR029577 TRPM5
IPR041491 TRPM_SLOG
PANTHERiPTHR13800:SF5 PTHR13800:SF5, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF18139 LSDAT_euk, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPM5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JJH7
Secondary accession number(s): A3KN89
, Q3TU14, Q7TPL4, Q99NF9, Q9EPM3, Q9EPM4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2000
Last modified: February 26, 2020
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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