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UniProtKB - Q9JJH5 (F262_RAT)

Entry version 162 (07 Apr 2021)
Sequence version 1 (01 Oct 2000)
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Protein

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

Gene

Pfkfb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Synthesis and degradation of fructose 2,6-bisphosphate.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The most important regulatory mechanism of these opposing activities is by phosphorylation and dephosphorylation of the enzyme.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei81Fructose 6-phosphateBy similarity1
Binding sitei105Fructose 6-phosphateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei131Sequence analysis1
Binding sitei133Fructose 6-phosphateBy similarity1
Binding sitei139Fructose 6-phosphateBy similarity1
Active sitei161Sequence analysis1
Binding sitei175Fructose 6-phosphateBy similarity1
Binding sitei196Fructose 6-phosphateBy similarity1
Binding sitei200Fructose 6-phosphateBy similarity1
Binding sitei259Fructose 2,6-bisphosphateBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei259Transition state stabilizerBy similarity1
Active sitei260Tele-phosphohistidine intermediateBy similarity1
Binding sitei266Fructose 2,6-bisphosphateBy similarity1
Sitei266Transition state stabilizerBy similarity1
Binding sitei272Fructose 2,6-bisphosphate; via amide nitrogenBy similarity1
Active sitei329Proton donor/acceptorBy similarity1
Binding sitei340Fructose 2,6-bisphosphateBy similarity1
Binding sitei354Fructose 2,6-bisphosphateBy similarity1
Binding sitei358Fructose 2,6-bisphosphateBy similarity1
Binding sitei369Fructose 2,6-bisphosphateBy similarity1
Sitei394Transition state stabilizerBy similarity1
Binding sitei395Fructose 2,6-bisphosphateBy similarity1
Binding sitei399Fructose 2,6-bisphosphateBy similarity1
Binding sitei431ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi48 – 56ATPBy similarity9
Nucleotide bindingi170 – 175ATPBy similarity6
Nucleotide bindingi351 – 354ATPBy similarity4
Nucleotide bindingi395 – 399ATPBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Kinase, Multifunctional enzyme, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.105, 5301
3.1.3.46, 5301

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-9634600, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q9JJH5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Short name:
6PF-2-K/Fru-2,6-P2ase 2
Short name:
PFK/FBPase 2
Alternative name(s):
6PF-2-K/Fru-2,6-P2ase heart-type isozyme
RH2K
Including the following 2 domains:
6-phosphofructo-2-kinase (EC:2.7.1.105)
Fructose-2,6-bisphosphatase (EC:3.1.3.46)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pfkfb2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Rat genome database

More...RGDi		3309, Pfkfb2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001799662 – 5576-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2Add BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei32Phosphoserine; by PKABy similarity1
Modified residuei469PhosphoserineCombined sources1
Modified residuei471PhosphothreonineBy similarity1
Modified residuei478Phosphothreonine; by PKCBy similarity1
Modified residuei486PhosphoserineCombined sources1
Modified residuei496PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by AMPK stimulates activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9JJH5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9JJH5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9JJH5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9JJH5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000004162, Expressed in stomach and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9JJH5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9JJH5, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2041, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000005729

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9JJH5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 2516-phosphofructo-2-kinaseAdd BLAST250
Regioni252 – 557Fructose-2,6-bisphosphataseAdd BLAST306

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the phosphoglycerate mutase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0234, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182835

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006383_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9JJH5

Identification of Orthologs from Complete Genome Data

More...OMAi		HDSCEWL

Database of Orthologous Groups

More...OrthoDBi		392001at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9JJH5

TreeFam database of animal gene trees

More...TreeFami		TF313541

Family and domain databases

Conserved Domains Database

More...CDDi		cd07067, HP_PGM_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1240, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003094, 6Pfruct_kin
IPR013079, 6Phosfructo_kin
IPR013078, His_Pase_superF_clade-1
IPR029033, His_PPase_superfam
IPR027417, P-loop_NTPase
IPR001345, PG/BPGM_mutase_AS

The PANTHER Classification System

More...PANTHERi		PTHR10606, PTHR10606, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01591, 6PF2K, 1 hit
PF00300, His_Phos_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00991, 6PFRUCTKNASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00855, PGAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit
SSF53254, SSF53254, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00175, PG_MUTASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q9JJH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSENSTFSTE DSSSSSYKPH ASNLRRAGKK CSWASYMTNS PTLIVMIGLP 
        60         70         80         90        100
ARGKTYVSKK LTRYLNWIGV PTKVFNLGVY RREAVKSYKS YDFFRHDNEE 
       110        120        130        140        150
AMKIRKQCAL VALEDVKAYF TEESGQIAVF DATNTTRERR DMILNFAKQN 
       160        170        180        190        200
AFKVFFVESV CDDPDVIAAN ILEVKVSSPD YPERNRENVM EDFLKRIECY 
       210        220        230        240        250
KVTYQPLDPD NYDKDLSFIK VMNVGQRFLV NRVQDYIQSK IVYYLMNIHV 
       260        270        280        290        300
HPRTIYLCRH GESEFNLLGK IGGDSGLSLR GKQFAQALKK FLEEQEIQDL 
       310        320        330        340        350
KVWTSQLKRT IQTAESLGVT YEQWKILNEI DAGVCEEMTY SEIEQRYPEE 
       360        370        380        390        400
FALRDQEKYL YRYPGGESYQ DLVQRLEPVI MELERQGNVL VISHQAVMRC 
       410        420        430        440        450
LLAYFLDKGA DELPYLRCPL HIIFKLTPVA YGCKVETITL NVEAVDTHRD 
       460        470        480        490        500
KPTHNFPKSQ TPVRMRRNSF TPLSSSNTIR RPRNYSVGSR PLKPLSPLRA 
       510        520        530        540        550
LDMQEGADQP KTQVQQGSAQ ATEHLQKALE FANGHREVEN VLAKHRRPSM 

ASLTLLS
Length:557
Mass (Da):64,156
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5707054E416629F
GO
Isoform 1 (identifier: Q9JJH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-519: QQGSA → SIPVV
     520-547: Missing.

Show »
Length:529
Mass (Da):60,916
Checksum:i013AABF875C60840
GO
Isoform 2 (identifier: Q9JJH5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-536: Missing.

Show »
Length:534
Mass (Da):61,653
Checksum:i88C635DE3964CD53
GO
Isoform 4 (identifier: Q9JJH5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     454-536: Missing.

Show »
Length:474
Mass (Da):54,823
Checksum:i1EDFF196B219764D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9DRP5C9DRP5_RAT
6-phosphofructo-2-kinase
Pfkfb2 pfkfb2
274Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R9PXY6R9PXY6_RAT
6-phosphofructo-2-kinase
Pfkfb2 rCG_46560
519Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004678454 – 536Missing in isoform 4. CuratedAdd BLAST83
Alternative sequenceiVSP_004676514 – 536Missing in isoform 2. CuratedAdd BLAST23
Alternative sequenceiVSP_004677515 – 519QQGSA → SIPVV in isoform 1. Curated5
Alternative sequenceiVSP_004679520 – 547Missing in isoform 1. CuratedAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S67900 mRNA Translation: AAB29678.1
L27084 mRNA Translation: AAA41132.1
AB040530 mRNA Translation: BAA96495.1
AB040531 mRNA Translation: BAA96496.1
AB040532 mRNA Translation: BAA96497.1
AB040533 mRNA Translation: BAA96498.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC2037

NCBI Reference Sequences

More...RefSeqi		NP_001029136.1, NM_001033964.2 [Q9JJH5-3]
NP_001029137.1, NM_001033965.2 [Q9JJH5-1]
NP_536725.2, NM_080477.3 [Q9JJH5-4]
XP_006249768.1, XM_006249706.3
XP_006249769.1, XM_006249707.3
XP_006249770.1, XM_006249708.1
XP_006249771.1, XM_006249709.3 [Q9JJH5-4]
XP_006249773.1, XM_006249711.3 [Q9JJH5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000005729; ENSRNOP00000005729; ENSRNOG00000004162 [Q9JJH5-1]
ENSRNOT00000037679; ENSRNOP00000030819; ENSRNOG00000004162 [Q9JJH5-4]
ENSRNOT00000050354; ENSRNOP00000044506; ENSRNOG00000004162 [Q9JJH5-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		24640

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:24640

UCSC genome browser

More...UCSCi		RGD:3309, rat [Q9JJH5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67900 mRNA Translation: AAB29678.1
L27084 mRNA Translation: AAA41132.1
AB040530 mRNA Translation: BAA96495.1
AB040531 mRNA Translation: BAA96496.1
AB040532 mRNA Translation: BAA96497.1
AB040533 mRNA Translation: BAA96498.1
PIRiJC2037
RefSeqiNP_001029136.1, NM_001033964.2 [Q9JJH5-3]
NP_001029137.1, NM_001033965.2 [Q9JJH5-1]
NP_536725.2, NM_080477.3 [Q9JJH5-4]
XP_006249768.1, XM_006249706.3
XP_006249769.1, XM_006249707.3
XP_006249770.1, XM_006249708.1
XP_006249771.1, XM_006249709.3 [Q9JJH5-4]
XP_006249773.1, XM_006249711.3 [Q9JJH5-1]

3D structure databases

SMRiQ9JJH5
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2041, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex
STRINGi10116.ENSRNOP00000005729

PTM databases

iPTMnetiQ9JJH5
PhosphoSitePlusiQ9JJH5

Proteomic databases

jPOSTiQ9JJH5
PaxDbiQ9JJH5

Genome annotation databases

EnsembliENSRNOT00000005729; ENSRNOP00000005729; ENSRNOG00000004162 [Q9JJH5-1]
ENSRNOT00000037679; ENSRNOP00000030819; ENSRNOG00000004162 [Q9JJH5-4]
ENSRNOT00000050354; ENSRNOP00000044506; ENSRNOG00000004162 [Q9JJH5-3]
GeneIDi24640
KEGGirno:24640
UCSCiRGD:3309, rat [Q9JJH5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5208
RGDi3309, Pfkfb2

Phylogenomic databases

eggNOGiKOG0234, Eukaryota
GeneTreeiENSGT00950000182835
HOGENOMiCLU_006383_1_1_1
InParanoidiQ9JJH5
OMAiHDSCEWL
OrthoDBi392001at2759
PhylomeDBiQ9JJH5
TreeFamiTF313541

Enzyme and pathway databases

BRENDAi2.7.1.105, 5301
3.1.3.46, 5301
ReactomeiR-RNO-9634600, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
SABIO-RKiQ9JJH5

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9JJH5

Gene expression databases

BgeeiENSRNOG00000004162, Expressed in stomach and 21 other tissues
ExpressionAtlasiQ9JJH5, baseline and differential
GenevisibleiQ9JJH5, RN

Family and domain databases

CDDicd07067, HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR003094, 6Pfruct_kin
IPR013079, 6Phosfructo_kin
IPR013078, His_Pase_superF_clade-1
IPR029033, His_PPase_superfam
IPR027417, P-loop_NTPase
IPR001345, PG/BPGM_mutase_AS
PANTHERiPTHR10606, PTHR10606, 1 hit
PfamiView protein in Pfam
PF01591, 6PF2K, 1 hit
PF00300, His_Phos_1, 1 hit
PRINTSiPR00991, 6PFRUCTKNASE
SMARTiView protein in SMART
SM00855, PGAM, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF53254, SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00175, PG_MUTASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF262_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JJH5
Secondary accession number(s): Q64297, Q9JHL5, Q9JJH4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: April 7, 2021
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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