UniProtKB - Q9JJH2 (GP173_RAT)
Protein
Probable G-protein coupled receptor 173
Gene
Gpr173
Organism
Rattus norvegicus (Rat)
Status
Functioni
Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (PubMed:27440717). It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (PubMed:27440717). In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth (By similarity).By similarity1 Publication
GO - Molecular functioni
- gonadotropin-releasing hormone receptor activity Source: RGD
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- negative regulation of neuron migration Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 173Alternative name(s): Super conserved receptor expressed in brain 3 |
Gene namesi | Name:Gpr173 Synonyms:Sreb3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620748, Gpr173 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 26 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 27 – 47 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 48 – 59 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 60 – 80 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 81 – 97 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 98 – 118 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 139 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 140 – 160 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 188 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 189 – 209 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 210 – 287 | CytoplasmicSequence analysisAdd BLAST | 78 | |
Transmembranei | 288 – 308 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 309 – 322 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 323 – 343 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 344 – 373 | CytoplasmicSequence analysisAdd BLAST | 30 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069652 | 1 – 373 | Probable G-protein coupled receptor 173Add BLAST | 373 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 96 ↔ 174 | PROSITE-ProRule annotation | ||
Glycosylationi | 184 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PRIDEi | Q9JJH2 |
PTM databases
GlyGeni | Q9JJH2, 2 sites |
PhosphoSitePlusi | Q9JJH2 |
Expressioni
Tissue specificityi
Expressed in the brain, preadipocytes and pancreatic islet cells.3 Publications
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
InParanoidi | Q9JJH2 |
OrthoDBi | 1311948at2759 |
PhylomeDBi | Q9JJH2 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9JJH2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANTTGEPEE VSGALSLPSA SAYVKLVLLG LIMCVSLAGN AILSLLVLKE
60 70 80 90 100
RALHKAPYYF LLDLCLADGI RSAICFPFVL ASVRHGSSWT FSALSCKIVA
110 120 130 140 150
FMAVLFCFHA AFMLFCISVT RYMAIAHHRF YAKRMTLWTC AAVICMAWTL
160 170 180 190 200
SVAMAFPPVF DVGTYKFIRE EDQCIFEHRY FKANDTLGFM LMLAVLMAAT
210 220 230 240 250
HAVYGKLLLF EYRHRKMKPV QMVPAISQNW TFHGPGATGQ AAANWIAGFG
260 270 280 290 300
RGPMPPTLLG IRQNGHAASR RLLGMDEVKG EKQLGRMFYA ITLLFLLLWS
310 320 330 340 350
PYIVACYWRV FVKACAVPHR YLATAVWMSF AQAAVNPIVC FLLNKDLKKC
360 370
LRTHAPCWGT GGAPAPREPY CVM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB040804 mRNA Translation: BAA96650.1 |
RefSeqi | NP_071591.1, NM_022255.1 |
Genome annotation databases
GeneIDi | 64021 |
KEGGi | rno:64021 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB040804 mRNA Translation: BAA96650.1 |
RefSeqi | NP_071591.1, NM_022255.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9JJH2, 2 sites |
PhosphoSitePlusi | Q9JJH2 |
Proteomic databases
PRIDEi | Q9JJH2 |
Genome annotation databases
GeneIDi | 64021 |
KEGGi | rno:64021 |
Organism-specific databases
CTDi | 54328 |
RGDi | 620748, Gpr173 |
Phylogenomic databases
InParanoidi | Q9JJH2 |
OrthoDBi | 1311948at2759 |
PhylomeDBi | Q9JJH2 |
Miscellaneous databases
PROi | PR:Q9JJH2 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP173_RAT | |
Accessioni | Q9JJH2Primary (citable) accession number: Q9JJH2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 14, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries