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Protein

Nitric oxide-associated protein 1

Gene

Noa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP.2 Publications

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • mitochondrial translation Source: UniProtKB
  • regulation of cell death Source: UniProtKB
  • regulation of cellular respiration Source: UniProtKB

Keywordsi

Biological processApoptosis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nitric oxide-associated protein 1
Gene namesi
Name:Noa1
ORF Names:MNCb-4931
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914306 Noa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Mice display mid-gestation lethality associated with a severe developmental defect of the embryo and trophoblast. Primary embryonic fibroblasts isolated from mutant E9.5 embryos show deficient mitochondrial synthesis and a global defect of oxidative phosphorylation.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi353K → R: Loss of ability to regulate activity of mitochondrial respiratory chain complexes. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002325111 – 693Nitric oxide-associated protein 1Add BLAST693

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JJG9
MaxQBiQ9JJG9
PaxDbiQ9JJG9
PeptideAtlasiQ9JJG9
PRIDEiQ9JJG9

PTM databases

iPTMnetiQ9JJG9
PhosphoSitePlusiQ9JJG9

Expressioni

Tissue specificityi

Expressed in tissues associated with high mitochondria content including testes, heart, liver, brain and thymus. Also expressed in various bone cell lines.1 Publication

Developmental stagei

At E10.5, weak but widespread expression. By E12.5 prominently expressed in the liver and also detected in developing CNS and dorsal root ganglia. At E14.5, expression is intensified in bone.1 Publication

Gene expression databases

BgeeiENSMUSG00000036285 Expressed in 287 organ(s), highest expression level in pancreas
CleanExiMM_2610024G14RIK
GenevisibleiQ9JJG9 MM

Interactioni

Subunit structurei

Homodimer or multimer. Interacts with mitochondrial complex I, DAP3, MRPL12 and MRPS27.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045948

Structurei

3D structure databases

ProteinModelPortaliQ9JJG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 504CP-type GPROSITE-ProRule annotationAdd BLAST302

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. NOA1 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1249 Eukaryota
COG1161 LUCA
GeneTreeiENSGT00390000001695
HOGENOMiHOG000026785
HOVERGENiHBG068278
InParanoidiQ9JJG9
KOiK19832
OMAiNPTPYRM
OrthoDBiEOG091G09M4
PhylomeDBiQ9JJG9
TreeFamiTF314460

Family and domain databases

InterProiView protein in InterPro
IPR030378 G_CP_dom
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51721 G_CP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JJG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPARLACGL LCGLRRGPAP AAACYGPARW LLEGKCEVPI RQRASSLGRR
60 70 80 90 100
VPPSSTATED YAEGPDTEER FLFPEYVPER TPEEQVRELQ ELRELQQLQQ
110 120 130 140 150
EKERERLQQR EERLQQKLRA GFRTLPVPEF PDASVPPSGI YCSGCGAELH
160 170 180 190 200
CQHPGLPGYL PEEKFRDAAQ AEGGPARTVC QRCWLLVHHG RALRLQVSRD
210 220 230 240 250
QYLELVSAAL RRPGPALVLY MVNLLDLPDA LLPDLPKLVG PKQLIVLGNK
260 270 280 290 300
VDLLPQDAPG YLKRLRKRLW DDCIRAGLVV APGHQGPQYP AGDEPLEEIK
310 320 330 340 350
NQNPSSRSRT VVKDVRLISA KTGYGVEEMI SALQRSWRYR GDVYLVGTTN
360 370 380 390 400
AGKSTLFNTL LESDYCTAKG SEAIDRATIS PWPGTTLNLL KFPICNPTPY
410 420 430 440 450
RMFKRQRRLQ EDATKAEEDL SEEEQSQLNQ LKKHGYIVGR VGRTFSYSRE
460 470 480 490 500
QDEVPFEFDA DSLAFDMGSE PVVSVCKSTK QIELTPEDVK DAHWFYDTPG
510 520 530 540 550
ITKESCILNL LTEKEINTVL PTHSIIPRTF VLKPGMVLFL GGIARIDFLQ
560 570 580 590 600
GNQSAWFTVV ASNFLPVHIT SLDKADALYE KHAGHELLLV PMGGKERMAQ
610 620 630 640 650
FPPLVAEDIT LKGGGKFEAV ADIKFSSAGW VAVTPYSEGT LHLRGHTPEG
660 670 680 690
TALTVHPPVL PYIVNVKGQR MKKSVAYKTK KPPSLVHNLK KHR
Length:693
Mass (Da):77,379
Last modified:October 1, 2000 - v1
Checksum:i946AB1752263903C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8C → R in BAE43128 (PubMed:16141072).Curated1
Sequence conflicti259P → T in BAE43128 (PubMed:16141072).Curated1
Sequence conflicti563N → S in BAE34011 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041537 mRNA Translation: BAA95022.1
AK017793 mRNA Translation: BAB30935.1
AK157246 mRNA Translation: BAE34011.1
AK172681 mRNA Translation: BAE43128.1
BC005689 mRNA Translation: AAH05689.1
BC017154 mRNA Translation: AAH17154.1
CCDSiCCDS19373.1
RefSeqiNP_062810.1, NM_019836.3
UniGeneiMm.129136

Genome annotation databases

EnsembliENSMUST00000047860; ENSMUSP00000045948; ENSMUSG00000036285
GeneIDi56412
KEGGimmu:56412
UCSCiuc008xwc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041537 mRNA Translation: BAA95022.1
AK017793 mRNA Translation: BAB30935.1
AK157246 mRNA Translation: BAE34011.1
AK172681 mRNA Translation: BAE43128.1
BC005689 mRNA Translation: AAH05689.1
BC017154 mRNA Translation: AAH17154.1
CCDSiCCDS19373.1
RefSeqiNP_062810.1, NM_019836.3
UniGeneiMm.129136

3D structure databases

ProteinModelPortaliQ9JJG9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045948

PTM databases

iPTMnetiQ9JJG9
PhosphoSitePlusiQ9JJG9

Proteomic databases

EPDiQ9JJG9
MaxQBiQ9JJG9
PaxDbiQ9JJG9
PeptideAtlasiQ9JJG9
PRIDEiQ9JJG9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047860; ENSMUSP00000045948; ENSMUSG00000036285
GeneIDi56412
KEGGimmu:56412
UCSCiuc008xwc.2 mouse

Organism-specific databases

CTDi84273
MGIiMGI:1914306 Noa1

Phylogenomic databases

eggNOGiKOG1249 Eukaryota
COG1161 LUCA
GeneTreeiENSGT00390000001695
HOGENOMiHOG000026785
HOVERGENiHBG068278
InParanoidiQ9JJG9
KOiK19832
OMAiNPTPYRM
OrthoDBiEOG091G09M4
PhylomeDBiQ9JJG9
TreeFamiTF314460

Miscellaneous databases

PROiPR:Q9JJG9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036285 Expressed in 287 organ(s), highest expression level in pancreas
CleanExiMM_2610024G14RIK
GenevisibleiQ9JJG9 MM

Family and domain databases

InterProiView protein in InterPro
IPR030378 G_CP_dom
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51721 G_CP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOA1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJG9
Secondary accession number(s): Q3T996, Q3U044, Q99JU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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