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Protein

Calcium-binding protein 8

Gene

Caln1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi49 – 601PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi85 – 962PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 8
Short name:
CaBP8
Alternative name(s):
Calneuron I
Calneuron-1
Gene namesi
Name:Caln1
Synonyms:Cabp8
ORF Names:MNCb-0849
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2155987 Caln1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 192CytoplasmicSequence analysisAdd BLAST192
Transmembranei193 – 213Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini214 – 219ExtracellularSequence analysis6

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735301 – 219Calcium-binding protein 8Add BLAST219

Proteomic databases

PaxDbiQ9JJG7
PRIDEiQ9JJG7

PTM databases

iPTMnetiQ9JJG7
PhosphoSitePlusiQ9JJG7

Expressioni

Tissue specificityi

Brain-specific. High expression in the cerebellum, hippocampus, and cortex.

Developmental stagei

Shows little prenatal expression, with highest expression at postnatal day 21.

Gene expression databases

BgeeiENSMUSG00000060371 Expressed in 114 organ(s), highest expression level in striatum
CleanExiMM_CALN1
ExpressionAtlasiQ9JJG7 baseline and differential
GenevisibleiQ9JJG7 MM

Interactioni

Subunit structurei

Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083193

Structurei

3D structure databases

ProteinModelPortaliQ9JJG7
SMRiQ9JJG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 71EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini72 – 107EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Domaini

The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.By similarity

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00740000115520
HOGENOMiHOG000252990
InParanoidiQ9JJG7
OMAiREKMPFH
PhylomeDBiQ9JJG7

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR001751 S100/CaBP-9k_CS
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9JJG7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFHHVTAGL LYKGNYLNRS LSAGSDSEQL ANISVEELDE IREAFRVLDR
60 70 80 90 100
DGNGFISKQE LGMAMRSLGY MPSEVELAII MQRLDMDGDG QVDFDEFMTI
110 120 130 140 150
LGPKLVSSEG RDGFLGNTID SIFWQFDMQR VTLEELKHIL YHAFRDHLTM
160 170 180 190 200
KDIENIIINE EESLNETSGN CQTEFEGVHS QKQNRQTCVR KSLICAFAMA
210
FIISVMLIAA NQILRSGME
Length:219
Mass (Da):24,823
Last modified:October 1, 2000 - v1
Checksum:iF43DA0D17FEB250F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WHE1F8WHE1_MOUSE
Calcium-binding protein 8
Caln1
261Annotation score:
A0A0J9YUK5A0A0J9YUK5_MOUSE
Calcium-binding protein 8
Caln1
70Annotation score:
A0A0J9YTS0A0A0J9YTS0_MOUSE
Calcium-binding protein 8
Caln1
76Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282251 mRNA Translation: AAK15156.1
AB041539 mRNA Translation: BAA95024.1
BC057129 mRNA Translation: AAH57129.1
BC058963 mRNA Translation: AAH58963.1
CCDSiCCDS19714.1
RefSeqiNP_067346.1, NM_021371.2
NP_851388.1, NM_181045.1
XP_006504436.1, XM_006504373.2
XP_006504437.1, XM_006504374.2
UniGeneiMm.320206
Mm.40875

Genome annotation databases

EnsembliENSMUST00000111287; ENSMUSP00000106918; ENSMUSG00000060371
ENSMUST00000111288; ENSMUSP00000106919; ENSMUSG00000060371
GeneIDi140904
KEGGimmu:140904
UCSCiuc008zuo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282251 mRNA Translation: AAK15156.1
AB041539 mRNA Translation: BAA95024.1
BC057129 mRNA Translation: AAH57129.1
BC058963 mRNA Translation: AAH58963.1
CCDSiCCDS19714.1
RefSeqiNP_067346.1, NM_021371.2
NP_851388.1, NM_181045.1
XP_006504436.1, XM_006504373.2
XP_006504437.1, XM_006504374.2
UniGeneiMm.320206
Mm.40875

3D structure databases

ProteinModelPortaliQ9JJG7
SMRiQ9JJG7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083193

PTM databases

iPTMnetiQ9JJG7
PhosphoSitePlusiQ9JJG7

Proteomic databases

PaxDbiQ9JJG7
PRIDEiQ9JJG7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111287; ENSMUSP00000106918; ENSMUSG00000060371
ENSMUST00000111288; ENSMUSP00000106919; ENSMUSG00000060371
GeneIDi140904
KEGGimmu:140904
UCSCiuc008zuo.2 mouse

Organism-specific databases

CTDi83698
MGIiMGI:2155987 Caln1

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00740000115520
HOGENOMiHOG000252990
InParanoidiQ9JJG7
OMAiREKMPFH
PhylomeDBiQ9JJG7

Miscellaneous databases

ChiTaRSiCaln1 mouse
PROiPR:Q9JJG7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060371 Expressed in 114 organ(s), highest expression level in striatum
CleanExiMM_CALN1
ExpressionAtlasiQ9JJG7 baseline and differential
GenevisibleiQ9JJG7 MM

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR001751 S100/CaBP-9k_CS
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCABP8_MOUSE
AccessioniPrimary (citable) accession number: Q9JJG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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