UniProtKB - Q9JJG6 (TMM47_MOUSE)
Protein
Transmembrane protein 47
Gene
Tmem47
Organism
Mus musculus (Mouse)
Status
Functioni
Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B (PubMed:26990309). During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (PubMed:21881001).2 Publications
GO - Biological processi
- cell-cell adhesion Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 47Alternative name(s): Transmembrane 4 superfamily member 10 |
Gene namesi | Name:Tmem47 Synonyms:Tm4sf10 ORF Names:MNCb-0941 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2177570, Tmem47 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
- Cell junction 2 Publications
- adherens junction By similarity
Note: In undifferentiated cultured podocytes localizes to the perinuclear region and translocates to the cell membrane after Cadherin appearance at cell-cell contacts. Upon differentiation of cultured podocytes, protein disappears from cell contacts and expression ceases. Re-expressed upon induced podocyte injury. Colocalizes with FYB1 at cell-cell contacts in podocytes.2 Publications
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- adherens junction Source: UniProtKB-SubCell
- cell-cell junction Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 21 – 41 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 83 – 103 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 115 – 135 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 152 – 172 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000072574 | 2 – 181 | Transmembrane protein 47Add BLAST | 180 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | Q9JJG6 |
PRIDEi | Q9JJG6 |
PTM databases
iPTMneti | Q9JJG6 |
PhosphoSitePlusi | Q9JJG6 |
Expressioni
Tissue specificityi
Expressed in podocytes (at protein level).1 Publication
Developmental stagei
Expression in kidney peaks at postnatal day 4 and declines to undetectable levels by day 15. In adults very low expression detected in the basal region of lateral membranes of few tubule segments (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000025666, Expressed in median eminence of neurohypophysis and 284 other tissues |
Genevisiblei | Q9JJG6, MM |
Interactioni
Subunit structurei
Interacts with CTNNB1, CTNNA1, PRKCI, PARD6B (By similarity).
Interacts with FYB1.
By similarity1 PublicationBinary interactionsi
Q9JJG6
With | #Exp. | IntAct |
---|---|---|
Fyb1 [O35601] | 4 | EBI-11685657,EBI-7353747 |
Protein-protein interaction databases
IntActi | Q9JJG6, 3 interactors |
STRINGi | 10090.ENSMUSP00000026760 |
Miscellaneous databases
RNActi | Q9JJG6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM47 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4671, Eukaryota |
GeneTreei | ENSGT00530000063484 |
HOGENOMi | CLU_120054_1_0_1 |
InParanoidi | Q9JJG6 |
OMAi | QYYLSMW |
OrthoDBi | 1307601at2759 |
PhylomeDBi | Q9JJG6 |
TreeFami | TF312855 |
Family and domain databases
InterProi | View protein in InterPro IPR015664, P53_induced |
PANTHERi | PTHR14399, PTHR14399, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9JJG6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASAGSGMEE VRVSVLTPLK LVGLVCIFLA LCLDLGAVLS PAWVTADHQY
60 70 80 90 100
YLSLWESCRK PANLDIWHCE STLGSDWQIA TLALLLGGAA IILIAFLVGL
110 120 130 140 150
ISICVGSRRR FYRPVAVMLF AAVVLQVCSL VLYPIKFIET VSLKIYHEFN
160 170 180
WGYGLAWGAT IFSFGGAILY CLNPKNYEDY Y
Sequence cautioni
The sequence BAE21843 differs from that shown. Reason: Frameshift.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034861 | 76 – 181 | DWQIA…YEDYY → GERPHPTSGAAPLAPAWPSW APPLPPPLWEPPPPLSFAPL PASLPYLLGPWTPGPSCMCP SLEGVRVGKTPETSYALYSS LAHPSSFGVTRLLFWAIVII EGENHVAV in isoform 2. 1 PublicationAdd BLAST | 106 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB041540 mRNA Translation: BAA95025.1 AK030761 mRNA Translation: BAC27126.1 AK031346 mRNA Translation: BAC27357.1 AK076147 mRNA Translation: BAC36217.1 AK133790 mRNA Translation: BAE21843.1 Frameshift. AK162304 mRNA Translation: BAE36842.1 AL671873 Genomic DNA No translation available. BC019751 mRNA Translation: AAH19751.1 |
CCDSi | CCDS30254.1 [Q9JJG6-1] |
RefSeqi | NP_620090.1, NM_138751.2 [Q9JJG6-1] |
Genome annotation databases
Ensembli | ENSMUST00000026760; ENSMUSP00000026760; ENSMUSG00000025666 [Q9JJG6-1] ENSMUST00000171953; ENSMUSP00000129793; ENSMUSG00000025666 [Q9JJG6-1] |
GeneIDi | 192216 |
KEGGi | mmu:192216 |
UCSCi | uc009tre.2, mouse [Q9JJG6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB041540 mRNA Translation: BAA95025.1 AK030761 mRNA Translation: BAC27126.1 AK031346 mRNA Translation: BAC27357.1 AK076147 mRNA Translation: BAC36217.1 AK133790 mRNA Translation: BAE21843.1 Frameshift. AK162304 mRNA Translation: BAE36842.1 AL671873 Genomic DNA No translation available. BC019751 mRNA Translation: AAH19751.1 |
CCDSi | CCDS30254.1 [Q9JJG6-1] |
RefSeqi | NP_620090.1, NM_138751.2 [Q9JJG6-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q9JJG6, 3 interactors |
STRINGi | 10090.ENSMUSP00000026760 |
PTM databases
iPTMneti | Q9JJG6 |
PhosphoSitePlusi | Q9JJG6 |
Proteomic databases
PaxDbi | Q9JJG6 |
PRIDEi | Q9JJG6 |
Protocols and materials databases
Antibodypediai | 71106, 27 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000026760; ENSMUSP00000026760; ENSMUSG00000025666 [Q9JJG6-1] ENSMUST00000171953; ENSMUSP00000129793; ENSMUSG00000025666 [Q9JJG6-1] |
GeneIDi | 192216 |
KEGGi | mmu:192216 |
UCSCi | uc009tre.2, mouse [Q9JJG6-1] |
Organism-specific databases
CTDi | 83604 |
MGIi | MGI:2177570, Tmem47 |
Phylogenomic databases
eggNOGi | KOG4671, Eukaryota |
GeneTreei | ENSGT00530000063484 |
HOGENOMi | CLU_120054_1_0_1 |
InParanoidi | Q9JJG6 |
OMAi | QYYLSMW |
OrthoDBi | 1307601at2759 |
PhylomeDBi | Q9JJG6 |
TreeFami | TF312855 |
Miscellaneous databases
BioGRID-ORCSi | 192216, 0 hits in 17 CRISPR screens |
PROi | PR:Q9JJG6 |
RNActi | Q9JJG6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025666, Expressed in median eminence of neurohypophysis and 284 other tissues |
Genevisiblei | Q9JJG6, MM |
Family and domain databases
InterProi | View protein in InterPro IPR015664, P53_induced |
PANTHERi | PTHR14399, PTHR14399, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TMM47_MOUSE | |
Accessioni | Q9JJG6Primary (citable) accession number: Q9JJG6 Secondary accession number(s): B1AUN5 Q8C0H5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families