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Protein

Transforming acidic coiled-coil-containing protein 2

Gene

Tacc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules (By similarity).By similarity2 Publications

GO - Molecular functioni

  • nuclear hormone receptor binding Source: MGI
  • protein domain specific binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming acidic coiled-coil-containing protein 2
Gene namesi
Name:Tacc2
ORF Names:MNCb-3527
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1928899 Tacc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice develop normally, are fertile, and do not present elevated tumorization rates. Cells deficient in TACC2 divide normally and do not show any change in the frequency of apoptosis induction.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001799891 – 1149Transforming acidic coiled-coil-containing protein 2Add BLAST1149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei100PhosphoserineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei354PhosphoserineCombined sources1
Modified residuei419PhosphoserineBy similarity1
Modified residuei439PhosphothreonineBy similarity1
Modified residuei510PhosphoserineCombined sources1
Modified residuei514PhosphoserineCombined sources1
Modified residuei516PhosphothreonineCombined sources1
Modified residuei552PhosphoserineCombined sources1
Modified residuei582PhosphoserineBy similarity1
Modified residuei585PhosphoserineCombined sources1
Modified residuei587PhosphoserineBy similarity1
Modified residuei596PhosphoserineBy similarity1
Modified residuei632PhosphothreonineBy similarity1
Modified residuei653PhosphothreonineBy similarity1
Modified residuei657PhosphothreonineBy similarity1
Modified residuei714PhosphoserineCombined sources1
Modified residuei736PhosphoserineBy similarity1
Modified residuei755PhosphothreonineCombined sources1
Modified residuei759PhosphoserineBy similarity1
Modified residuei771PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated; which is required for localization in centrosome.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JJG0
PeptideAtlasiQ9JJG0
PRIDEiQ9JJG0

PTM databases

iPTMnetiQ9JJG0

Expressioni

Tissue specificityi

Expressed in brain, kidney, lung, thymus and ovary. Not detectable in normal tissues at protein level.1 Publication

Gene expression databases

ExpressionAtlasiQ9JJG0 baseline and differential

Interactioni

Subunit structurei

Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF (By similarity). Interacts with CCDC100/CEP120.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JJG0, 1 interactor
STRINGi10090.ENSMUSP00000081561

Structurei

3D structure databases

ProteinModelPortaliQ9JJG0
SMRiQ9JJG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini508 – 596SPAZAdd BLAST89

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili877 – 905Sequence analysisAdd BLAST29
Coiled coili948 – 1148Sequence analysisAdd BLAST201

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 165Poly-Pro9
Compositional biasi610 – 613Poly-Lys4

Sequence similaritiesi

Belongs to the TACC family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIVK Eukaryota
ENOG410YMFS LUCA
GeneTreeiENSGT00530000063855
HOGENOMiHOG000294120
HOVERGENiHBG055954
InParanoidiQ9JJG0
KOiK14282
PhylomeDBiQ9JJG0

Family and domain databases

InterProiView protein in InterPro
IPR039915 Alp7/TACC
IPR007707 TACC_C
PANTHERiPTHR13924 PTHR13924, 1 hit
PfamiView protein in Pfam
PF05010 TACC, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JJG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNENSTSDH QRTSSVQSPR SLQPPGKSQS LQKQQGDLPG SCAGSIPGTD
60 70 80 90 100
DVIQPAAPVD PGHPPLAGIG SNQGEVCTSL QLSYTIVTVQ SASPSAARAS
110 120 130 140 150
PAPLAPEHTA SAPSAAGPGV EVTPTGSPQH LAKNEPRSSD SEEAFETPES
160 170 180 190 200
TTPVKAPPAP PPPPPEVTPE PEVIDPPAPE EPGCISEPPV VVPDGPRSSE
210 220 230 240 250
SVEGSPFRPS HSSSAVFDED KPIASSGTYN LDFDSIELVD NFQSLEPCSA
260 270 280 290 300
DSKGQECKVS TRRKSTESVP PSKSTLSRSL SLQASDFDGA SCPGSPEAGT
310 320 330 340 350
LTTDACGTGS NSASSTLKRT KKTRPPSLKK KQATKKPTET PPVKETQQEP
360 370 380 390 400
GEESPVPSEE HLAPETKTES ATPEGAGCTL SDDTPLESPA VPTATCPLTL
410 420 430 440 450
ESAEDVSPLV SGGGRVQNSP PVGRKSVPLT TASEAVEVTL SDSGGQEDLP
460 470 480 490 500
AKGLSVRLEF DYSEDKGSWE SQQENAPPTK KIGKKPVAKM PLRRPKMKKT
510 520 530 540 550
PEKLDNTPAS PPRSPTEPSD TPIAKGTYTF DIDKWDDPNF NPFSSTSKMQ
560 570 580 590 600
ESPKLSQQSY NFDPDACEES LDPFKASSKT PSSPSKSPAS FEIPASTTEA
610 620 630 640 650
DGDGLNKPAK KKKTPLKTMV EDVMSVCSLF DTFRVKKSPK RSPLSDPPSQ
660 670 680 690 700
DPTPAATPEA PSAISTVVHA TDEEKLAVTS QKWTCMTVDL DADKQDFPQP
710 720 730 740 750
SDLSNFVNET KFNSPSEELD YRNSYEIEYM EKLGSSLPQD DDTPKKQALY
760 770 780 790 800
LMFDTPQESP VKSPPVRMSD SPTPCSGSSF EDTEALVNAA TKLQHPVARG
810 820 830 840 850
LPSSQEPLLQ VPEKPSQKEL EAMALGTPAE AIEITAPEGA FASADTLLSR
860 870 880 890 900
LAHPASLCGA LGYLEPDLAE KNPPVFAQKL QEELEFAVMR IEALKLARQI
910 920 930 940 950
ALASRSRQDT KREAAHPPDV SISKTALYSR IGSTEVEKPP GLLFQQPDLD
960 970 980 990 1000
SALQVARAEV IAKEREVSEW RDKYEESRRE VVEMRKIVAE YEKTIAQMIP
1010 1020 1030 1040 1050
GTERKILSHQ TVQQLVLEKE QALADLNSVE KSLADLFRRY EKMKEVLEGF
1060 1070 1080 1090 1100
RKNEEVLKKC AQEYLSRVKK EEQRYQALKV HAEEKLDRAN AEIAQVRGKA
1110 1120 1130 1140
QQEQAAYQAS LRKEQLRVDA LERTLEQKNK EIEELTKICD ELIAKMGKS
Length:1,149
Mass (Da):124,130
Last modified:January 9, 2007 - v2
Checksum:i9B4A46B38747898E
GO
Isoform 2 (identifier: Q9JJG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     115-137: AAGPGVEVTPTGSPQHLAKNEPR → MGGSQSLQPAPASDLNLEVSEAM

Show »
Length:1,035
Mass (Da):112,716
Checksum:i0698015282F94C78
GO
Isoform 3 (identifier: Q9JJG0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     115-137: AAGPGVEVTPTGSPQHLAKNEPR → MGGSQSLQPAPASDLNLEVSEAM
     619-630: Missing.
     835-911: Missing.
     1000-1007: PGTERKIL → EDEQREKSI

Show »
Length:947
Mass (Da):103,276
Checksum:i7C90DFA1A41C7E05
GO
Isoform 4 (identifier: Q9JJG0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-489: Missing.
     619-630: Missing.
     717-717: E → EGKQLGGQPDPHLALENTVPRGQRARK
     835-911: Missing.
     1000-1007: PGTERKIL → EDEQREKSI

Show »
Length:598
Mass (Da):67,057
Checksum:i3624051C22F57997
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q8T1E9Q8T1_MOUSE
Transforming acidic coiled-coil-con...
Tacc2
2,879Annotation score:
E9Q9Z4E9Q9Z4_MOUSE
Transforming acidic coiled-coil-con...
Tacc2
1,146Annotation score:
E9QL08E9QL08_MOUSE
Transforming acidic coiled-coil-con...
Tacc2
1,036Annotation score:
A0A140LIQ6A0A140LIQ6_MOUSE
Transforming acidic coiled-coil-con...
Tacc2
829Annotation score:
A0A140LIJ2A0A140LIJ2_MOUSE
Transforming acidic coiled-coil-con...
Tacc2
568Annotation score:
A0A140LI86A0A140LI86_MOUSE
Transforming acidic coiled-coil-con...
Tacc2
1,020Annotation score:
A0A140LIQ1A0A140LIQ1_MOUSE
Transforming acidic coiled-coil-con...
Tacc2
555Annotation score:
A0A140LJ29A0A140LJ29_MOUSE
Transforming acidic coiled-coil-con...
Tacc2
696Annotation score:
A0A140LJA0A0A140LJA0_MOUSE
Transforming acidic coiled-coil-con...
Tacc2
910Annotation score:
A0A140LI64A0A140LI64_MOUSE
Transforming acidic coiled-coil-con...
Tacc2
255Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti681Q → K in BAC34486 (PubMed:16141072).Curated1
Sequence conflicti1129 – 1132NKEI → DKQR in BAC34486 (PubMed:16141072).Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0221591 – 489Missing in isoform 4. 1 PublicationAdd BLAST489
Alternative sequenceiVSP_0221601 – 114Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST114
Alternative sequenceiVSP_022161115 – 137AAGPG…KNEPR → MGGSQSLQPAPASDLNLEVS EAM in isoform 2 and isoform 3. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_022162619 – 630Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_022163717E → EGKQLGGQPDPHLALENTVP RGQRARK in isoform 4. 1 Publication1
Alternative sequenceiVSP_022164835 – 911Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST77
Alternative sequenceiVSP_0221651000 – 1007PGTERKIL → EDEQREKSI in isoform 3 and isoform 4. 2 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177410 mRNA Translation: AAO18641.1
AB041546 mRNA Translation: BAA95031.1
AK050985 mRNA Translation: BAC34486.1
AK165603 mRNA Translation: BAE38287.1
BC004057 mRNA Translation: AAH04057.1
CCDSiCCDS85432.1 [Q9JJG0-3]
RefSeqiNP_001334566.1, NM_001347637.1 [Q9JJG0-3]
NP_067289.2, NM_021314.4
NP_996738.2, NM_206856.3
UniGeneiMm.86322

Genome annotation databases

EnsembliENSMUST00000207282; ENSMUSP00000146848; ENSMUSG00000030852 [Q9JJG0-3]
GeneIDi57752
KEGGimmu:57752
UCSCiuc009kag.1 mouse [Q9JJG0-3]
uc009kan.1 mouse [Q9JJG0-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177410 mRNA Translation: AAO18641.1
AB041546 mRNA Translation: BAA95031.1
AK050985 mRNA Translation: BAC34486.1
AK165603 mRNA Translation: BAE38287.1
BC004057 mRNA Translation: AAH04057.1
CCDSiCCDS85432.1 [Q9JJG0-3]
RefSeqiNP_001334566.1, NM_001347637.1 [Q9JJG0-3]
NP_067289.2, NM_021314.4
NP_996738.2, NM_206856.3
UniGeneiMm.86322

3D structure databases

ProteinModelPortaliQ9JJG0
SMRiQ9JJG0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JJG0, 1 interactor
STRINGi10090.ENSMUSP00000081561

PTM databases

iPTMnetiQ9JJG0

Proteomic databases

PaxDbiQ9JJG0
PeptideAtlasiQ9JJG0
PRIDEiQ9JJG0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000207282; ENSMUSP00000146848; ENSMUSG00000030852 [Q9JJG0-3]
GeneIDi57752
KEGGimmu:57752
UCSCiuc009kag.1 mouse [Q9JJG0-3]
uc009kan.1 mouse [Q9JJG0-4]

Organism-specific databases

CTDi10579
MGIiMGI:1928899 Tacc2

Phylogenomic databases

eggNOGiENOG410IIVK Eukaryota
ENOG410YMFS LUCA
GeneTreeiENSGT00530000063855
HOGENOMiHOG000294120
HOVERGENiHBG055954
InParanoidiQ9JJG0
KOiK14282
PhylomeDBiQ9JJG0

Miscellaneous databases

PROiPR:Q9JJG0
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ9JJG0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR039915 Alp7/TACC
IPR007707 TACC_C
PANTHERiPTHR13924 PTHR13924, 1 hit
PfamiView protein in Pfam
PF05010 TACC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTACC2_MOUSE
AccessioniPrimary (citable) accession number: Q9JJG0
Secondary accession number(s): Q3TN02
, Q811U0, Q8BQD4, Q99KQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 9, 2007
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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